SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c95'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 4c95 DNA POLYMERASE
ALPHA-BINDING
PROTEIN
(Saccharomyces
cerevisiae) 		4 / 8 SER A 637
VAL A 628
SER A 627
LYS A 648
 None
 1.17A 1hwiB-4c95A:
undetectable		 1hwiB-4c95A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 4c95 DNA POLYMERASE
ALPHA-BINDING
PROTEIN
(Saccharomyces
cerevisiae) 		4 / 8 SER A 637
VAL A 628
SER A 627
LYS A 648
 None
 1.20A 1hwkA-4c95A:
undetectable		 1hwkA-4c95A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 4c95 DNA POLYMERASE
ALPHA-BINDING
PROTEIN
(Saccharomyces
cerevisiae) 		4 / 8 SER A 637
VAL A 628
SER A 627
LYS A 648
 None
 1.17A 1hwkC-4c95A:
undetectable		 1hwkC-4c95A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 4c95 DNA POLYMERASE
ALPHA-BINDING
PROTEIN
(Saccharomyces
cerevisiae) 		4 / 8 SER A 637
VAL A 628
SER A 627
LYS A 648
 None
 1.17A 1hwkD-4c95A:
undetectable		 1hwkD-4c95A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4c95 DNA POLYMERASE
ALPHA-BINDING
PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 885
PHE A 870
LEU A 867
ALA A 894
 None
 0.72A 1j8uA-4c95A:
undetectable		 1j8uA-4c95A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 4c95 DNA POLYMERASE
ALPHA-BINDING
PROTEIN
(Saccharomyces
cerevisiae) 		4 / 5 ALA A 865
TYR A 827
ALA A 861
TYR A 862
 None
 1.06A 1xl6A-4c95A:
undetectable
1xl6B-4c95A:
undetectable		 1xl6A-4c95A:
20.28
1xl6B-4c95A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 4c95 DNA POLYMERASE
ALPHA-BINDING
PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 SER A 631
TYR A 630
HIS A 629
 None
 0.72A 2r2vD-4c95A:
undetectable		 2r2vD-4c95A:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 4c95 DNA POLYMERASE
ALPHA-BINDING
PROTEIN
(Saccharomyces
cerevisiae) 		4 / 4 ALA A 865
TYR A 827
ALA A 861
TYR A 862
 None
 1.06A 2wlkA-4c95A:
undetectable
2wlkB-4c95A:
undetectable		 2wlkA-4c95A:
20.28
2wlkB-4c95A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_A_ACHA301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4c95 DNA POLYMERASE
ALPHA-BINDING
PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 TRP A 763
THR A 484
TYR A 677
ARG A 492
 None
 1.33A 3wipA-4c95A:
undetectable
3wipB-4c95A:
undetectable		 3wipA-4c95A:
17.82
3wipB-4c95A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4c95 DNA POLYMERASE
ALPHA-BINDING
PROTEIN
(Saccharomyces
cerevisiae) 		4 / 8 TRP A 763
THR A 484
TYR A 677
ARG A 492
 None
 1.26A 3wipB-4c95A:
undetectable
3wipC-4c95A:
undetectable		 3wipB-4c95A:
17.82
3wipC-4c95A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_D_ACHD301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4c95 DNA POLYMERASE
ALPHA-BINDING
PROTEIN
(Saccharomyces
cerevisiae) 		4 / 8 TRP A 763
THR A 484
TYR A 677
ARG A 492
 None
 1.28A 3wipD-4c95A:
undetectable
3wipE-4c95A:
undetectable		 3wipD-4c95A:
17.82
3wipE-4c95A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_E_ACHE301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4c95 DNA POLYMERASE
ALPHA-BINDING
PROTEIN
(Saccharomyces
cerevisiae) 		4 / 8 ARG A 492
TRP A 763
THR A 484
TYR A 677
 None
 1.23A 3wipA-4c95A:
undetectable
3wipE-4c95A:
undetectable		 3wipA-4c95A:
17.82
3wipE-4c95A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4c95 DNA POLYMERASE
ALPHA-BINDING
PROTEIN
(Saccharomyces
cerevisiae) 		4 / 8 TRP A 763
THR A 484
TYR A 677
ARG A 492
 None
 1.27A 3wipG-4c95A:
undetectable
3wipH-4c95A:
undetectable		 3wipG-4c95A:
17.82
3wipH-4c95A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4c95 DNA POLYMERASE
ALPHA-BINDING
PROTEIN
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 615
VAL A 581
LEU A 545
ILE A 589
 None
 0.84A 4asdA-4c95A:
undetectable		 4asdA-4c95A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 4c95 DNA POLYMERASE
ALPHA-BINDING
PROTEIN
(Saccharomyces
cerevisiae) 		4 / 9 TYR A 526
PHE A 517
HIS A 559
PHE A 546
 None
 1.17A 4jvlA-4c95A:
undetectable		 4jvlA-4c95A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 4c95 DNA POLYMERASE
ALPHA-BINDING
PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 535
GLY A 533
ASP A 530
 None
 0.65A 4xdtA-4c95A:
undetectable		 4xdtA-4c95A:
21.24