SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4c9b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 4c9b PRE-MRNA-SPLICING
FACTOR CWC22 HOMOLOG
(Homo
sapiens) 		4 / 4 GLY B 195
LEU B 382
GLY B 193
ARG B 194
 None
 1.00A 1j7kA-4c9bB:
undetectable		 1j7kA-4c9bB:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 4c9b PRE-MRNA-SPLICING
FACTOR CWC22 HOMOLOG
(Homo
sapiens) 		4 / 6 PHE B 296
ALA B 293
LEU B 297
ILE B 315
 None
 0.93A 1sbrA-4c9bB:
undetectable
1sbrB-4c9bB:
undetectable		 1sbrA-4c9bB:
21.48
1sbrB-4c9bB:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 4c9b PRE-MRNA-SPLICING
FACTOR CWC22 HOMOLOG
(Homo
sapiens) 		5 / 12 LEU B 239
ALA B 256
GLN B 205
LEU B 263
LEU B 273
 None
 1.42A 2oaxC-4c9bB:
undetectable		 2oaxC-4c9bB:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 4c9b PRE-MRNA-SPLICING
FACTOR CWC22 HOMOLOG
(Homo
sapiens) 		4 / 6 ASP B 374
ILE B 238
LEU B 273
GLU B 231
 None
 1.07A 2ya7A-4c9bB:
undetectable		 2ya7A-4c9bB:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 4c9b PRE-MRNA-SPLICING
FACTOR CWC22 HOMOLOG
(Homo
sapiens) 		5 / 12 LEU B 304
ILE B 315
LEU B 282
PHE B 241
VAL B 260
 None
 1.17A 2ygpA-4c9bB:
undetectable		 2ygpA-4c9bB:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4c9b PRE-MRNA-SPLICING
FACTOR CWC22 HOMOLOG
(Homo
sapiens) 		4 / 4 ILE B 170
GLN B 205
ILE B 181
LEU B 237
 None
 1.06A 3dzyD-4c9bB:
undetectable		 3dzyD-4c9bB:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 4c9b PRE-MRNA-SPLICING
FACTOR CWC22 HOMOLOG
(Homo
sapiens) 		4 / 6 GLN B 187
LEU B 185
GLU B 184
LEU B 169
 None
 0.85A 3h5gA-4c9bB:
undetectable
3h5gC-4c9bB:
undetectable		 3h5gA-4c9bB:
9.63
3h5gC-4c9bB:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 4c9b PRE-MRNA-SPLICING
FACTOR CWC22 HOMOLOG
(Homo
sapiens) 		5 / 12 LEU B 239
ALA B 256
GLN B 205
LEU B 263
LEU B 273
 None
 1.46A 3vhuA-4c9bB:
undetectable		 3vhuA-4c9bB:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 4c9b PRE-MRNA-SPLICING
FACTOR CWC22 HOMOLOG
(Homo
sapiens) 		5 / 8 LEU B 185
ILE B 222
ASN B 223
GLY B 230
ILE B 233
 None
 1.12A 3wxoA-4c9bB:
undetectable		 3wxoA-4c9bB:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME
KP18CYS PEPTIDE)		 4c9b PRE-MRNA-SPLICING
FACTOR CWC22 HOMOLOG
(Homo
sapiens) 		5 / 12 GLN B 228
GLU B 379
SER B 198
VAL B 219
ILE B 222
 None
 1.31A 4k38A-4c9bB:
undetectable
4k38D-4c9bB:
undetectable		 4k38A-4c9bB:
20.85
4k38D-4c9bB:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4c9b PRE-MRNA-SPLICING
FACTOR CWC22 HOMOLOG
(Homo
sapiens) 		5 / 11 ALA B 261
MET B 277
LEU B 278
LEU B 281
ILE B 294
 None
 1.10A 4xumB-4c9bB:
undetectable		 4xumB-4c9bB:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4c9b PRE-MRNA-SPLICING
FACTOR CWC22 HOMOLOG
(Homo
sapiens) 		4 / 5 ALA B 400
TYR B 398
HIS B 368
PHE B 226
 None
 1.31A 4ze2A-4c9bB:
undetectable		 4ze2A-4c9bB:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 4c9b PRE-MRNA-SPLICING
FACTOR CWC22 HOMOLOG
(Homo
sapiens) 		4 / 7 ILE B 405
ILE B 190
SER B 224
LEU B 185
 None
 0.75A 5fukA-4c9bB:
undetectable
5fukB-4c9bB:
undetectable		 5fukA-4c9bB:
20.59
5fukB-4c9bB:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 4c9b PRE-MRNA-SPLICING
FACTOR CWC22 HOMOLOG
(Homo
sapiens) 		4 / 8 ILE B 233
LEU B 185
ILE B 182
TYR B 215
 None
 0.99A 5ieoA-4c9bB:
undetectable		 5ieoA-4c9bB:
17.18