SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cab'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B8J_B_ADNB331_1
(CLASS B ACID
PHOSPHATASE)		 4cab CATALASE
(Deinococcus
radiodurans) 		5 / 10 SER A 357
PHE A 356
LEU A 350
GLY A 346
TYR A 231
 None
 1.33A 2b8jB-4cabA:
undetectable		 2b8jB-4cabA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NCQ_B_ACTB120_0
(NITROGEN REGULATORY
PROTEIN P-II
(GLNB-2))		 4cab CATALASE
(Deinococcus
radiodurans) 		4 / 4 MET A 361
LYS A 360
ASP A 359
ASP A 168
 HEM  A 537 (-3.9A)
None
None
None
 1.17A 3ncqB-4cabA:
0.0		 3ncqB-4cabA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 4cab CATALASE
(Deinococcus
radiodurans) 		6 / 12 THR A 126
PHE A 143
GLY A 158
ALA A  87
GLY A  86
MET A 327
 None
None
HEM  A 537 (-4.0A)
None
None
None
 1.41A 3v3oA-4cabA:
undetectable		 3v3oA-4cabA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 4cab CATALASE
(Deinococcus
radiodurans) 		5 / 12 PHE A 143
GLY A 158
ALA A  87
GLY A  86
MET A 327
 None
HEM  A 537 (-4.0A)
None
None
None
 1.12A 3v3oB-4cabA:
undetectable		 3v3oB-4cabA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1507_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4cab CATALASE
(Deinococcus
radiodurans) 		3 / 3 ARG A 107
LYS A 109
ARG A 432
 None
 1.43A 3w1wA-4cabA:
undetectable
3w1wB-4cabA:
undetectable		 3w1wA-4cabA:
20.75
3w1wB-4cabA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 4cab CATALASE
(Deinococcus
radiodurans) 		5 / 11 PHE A 143
GLY A 158
ALA A  87
GLY A  86
MET A 327
 None
HEM  A 537 (-4.0A)
None
None
None
 1.25A 4a6nA-4cabA:
undetectable		 4a6nA-4cabA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 4cab CATALASE
(Deinococcus
radiodurans) 		3 / 3 THR A 208
ASN A 453
PHE A 305
 None
 0.82A 4pd9A-4cabA:
undetectable		 4pd9A-4cabA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 4cab CATALASE
(Deinococcus
radiodurans) 		3 / 3 THR A 273
ASN A 335
PHE A 337
 None
 0.80A 4pd9A-4cabA:
undetectable		 4pd9A-4cabA:
21.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QOP_C_HQEC503_1
(CATALASE)		 4cab CATALASE
(Deinococcus
radiodurans) 		4 / 8 ASP A 139
PRO A 140
PHE A 165
LEU A 210
 None
 0.25A 4qopC-4cabA:
55.1		 4qopC-4cabA:
51.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 4cab CATALASE
(Deinococcus
radiodurans) 		4 / 7 MET A 223
HIS A  81
GLY A 158
ASN A 159
 None
HEM  A 537 (-3.4A)
HEM  A 537 (-4.0A)
HEM  A 537 (-3.5A)
 1.29A 5a5zC-4cabA:
undetectable		 5a5zC-4cabA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4cab CATALASE
(Deinococcus
radiodurans) 		4 / 8 TYR A 369
ASP A 359
VAL A 157
GLY A 158
 HEM  A 537 (-4.2A)
None
HEM  A 537 (-4.9A)
HEM  A 537 (-4.0A)
 0.91A 5nzyA-4cabA:
undetectable		 5nzyA-4cabA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4cab CATALASE
(Deinococcus
radiodurans) 		3 / 3 GLY A  89
THR A 328
ASN A 330
 None
 0.71A 5odiG-4cabA:
undetectable		 5odiG-4cabA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 4cab CATALASE
(Deinococcus
radiodurans) 		4 / 8 GLY A 152
GLN A 373
TYR A 381
ASP A 155
 None
HEM  A 537 (-4.3A)
None
None
 1.06A 5vlmB-4cabA:
undetectable		 5vlmB-4cabA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 4cab CATALASE
(Deinococcus
radiodurans) 		4 / 7 GLY A 152
GLN A 373
TYR A 381
ASP A 155
 None
HEM  A 537 (-4.3A)
None
None
 0.92A 5vlmE-4cabA:
undetectable		 5vlmE-4cabA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 4cab CATALASE
(Deinococcus
radiodurans) 		4 / 7 GLY A 152
GLN A 373
TYR A 381
ASP A 155
 None
HEM  A 537 (-4.3A)
None
None
 1.02A 5vlmG-4cabA:
undetectable		 5vlmG-4cabA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4cab CATALASE
(Deinococcus
radiodurans) 		5 / 12 GLU A 248
GLY A 252
MET A 327
VAL A 122
GLY A 225
 None
 1.12A 5vooD-4cabA:
undetectable		 5vooD-4cabA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 4cab CATALASE
(Deinococcus
radiodurans) 		4 / 5 ALA A 203
SER A 200
GLY A 199
TYR A 495
 None
 1.26A 5yodB-4cabA:
undetectable		 5yodB-4cabA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 4cab CATALASE
(Deinococcus
radiodurans) 		4 / 6 ARG A 374
GLY A 378
SER A 370
THR A 372
 CL  A1537 (-3.4A)
None
None
HEM  A 537 (-3.7A)
 0.95A 5ysiA-4cabA:
undetectable		 5ysiA-4cabA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 4cab CATALASE
(Deinococcus
radiodurans) 		5 / 12 PHE A 111
VAL A  97
VAL A 145
PHE A  91
VAL A 292
 None
 1.26A 6ap6A-4cabA:
undetectable		 6ap6A-4cabA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 4cab CATALASE
(Deinococcus
radiodurans) 		5 / 12 PHE A 111
VAL A  97
VAL A 145
PHE A  91
VAL A 292
 None
 1.25A 6ap6B-4cabA:
undetectable		 6ap6B-4cabA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 4cab CATALASE
(Deinococcus
radiodurans) 		3 / 3 TYR A 404
PRO A 385
LEU A 384
 None
 0.91A 6beoA-4cabA:
undetectable		 6beoA-4cabA:
1.54