SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cad'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 4cad RAS AND A-FACTOR
CONVERTING ENZYME 1,
RCE1
(Methanococcus
maripaludis) 		3 / 3 TRP C 172
VAL C  18
TRP C  24
 None
 1.09A 1c4dA-4cadC:
undetectable
1c4dB-4cadC:
undetectable		 1c4dA-4cadC:
7.69
1c4dB-4cadC:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 4cad RAS AND A-FACTOR
CONVERTING ENZYME 1,
RCE1
(Methanococcus
maripaludis) 		5 / 10 LEU C 132
LEU C 135
ALA C 136
LEU C  48
LEU C  45
 None
 0.89A 1gwrA-4cadC:
undetectable		 1gwrA-4cadC:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4cad ANTIBODY FAB
FRAGMENT HEAVY CHAIN
(Mus
musculus) 		5 / 7 GLY B  54
PRO B  53
THR B  58
ILE B  51
GLY B  56
 None
 1.17A 1usqF-4cadB:
undetectable		 1usqF-4cadB:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 4cad RAS AND A-FACTOR
CONVERTING ENZYME 1,
RCE1
(Methanococcus
maripaludis) 		5 / 12 LEU C 229
ILE C 230
ASN C 233
VAL C  96
LEU C  92
 None
None
BOG  C 301 (-3.0A)
None
None
 1.32A 2bxfB-4cadC:
2.8		 2bxfB-4cadC:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4cad ANTIBODY FAB
FRAGMENT HEAVY CHAIN
(Mus
musculus) 		5 / 7 GLY B  54
PRO B  53
THR B  58
ILE B  51
GLY B  56
 None
 1.17A 2jkjE-4cadB:
undetectable		 2jkjE-4cadB:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4cad ANTIBODY FAB
FRAGMENT HEAVY CHAIN
(Mus
musculus) 		5 / 7 GLY B  54
PRO B  53
THR B  58
ILE B  51
GLY B  56
 None
 1.18A 2jklE-4cadB:
undetectable		 2jklE-4cadB:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 4cad RAS AND A-FACTOR
CONVERTING ENZYME 1,
RCE1
(Methanococcus
maripaludis) 		3 / 3 GLY C  38
TYR C  40
SER C  37
 None
 0.75A 2xatA-4cadC:
undetectable		 2xatA-4cadC:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4cad RAS AND A-FACTOR
CONVERTING ENZYME 1,
RCE1
(Methanococcus
maripaludis) 		5 / 10 THR C  26
ILE C  43
GLY C  27
TYR C  40
PRO C  46
 None
 1.41A 2y7pA-4cadC:
undetectable		 2y7pA-4cadC:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4cad RAS AND A-FACTOR
CONVERTING ENZYME 1,
RCE1
(Methanococcus
maripaludis) 		4 / 5 PHE C 165
PHE C 149
LEU C 158
PHE C 266
 None
 1.17A 3ag3C-4cadC:
undetectable
3ag3J-4cadC:
undetectable		 3ag3C-4cadC:
24.48
3ag3J-4cadC:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 4cad RAS AND A-FACTOR
CONVERTING ENZYME 1,
RCE1
(Methanococcus
maripaludis) 		4 / 5 ASP C 150
ARG C 145
ILE C 220
THR C  16
 None
 1.25A 3eigA-4cadC:
undetectable		 3eigA-4cadC:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 4cad RAS AND A-FACTOR
CONVERTING ENZYME 1,
RCE1
(Methanococcus
maripaludis) 		5 / 12 LEU C 132
LEU C 135
ALA C 136
LEU C  48
LEU C  45
 None
 0.84A 3olsA-4cadC:
undetectable		 3olsA-4cadC:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 4cad RAS AND A-FACTOR
CONVERTING ENZYME 1,
RCE1
(Methanococcus
maripaludis) 		5 / 12 LEU C 132
LEU C 135
ALA C 136
LEU C  48
LEU C  45
 None
 0.87A 4pxmA-4cadC:
undetectable		 4pxmA-4cadC:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 4cad RAS AND A-FACTOR
CONVERTING ENZYME 1,
RCE1
(Methanococcus
maripaludis) 		5 / 11 LEU C 135
ALA C 136
LEU C  48
MET C  44
LEU C  45
 None
 1.16A 5dxgB-4cadC:
undetectable		 5dxgB-4cadC:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 4cad ANTIBODY FAB
FRAGMENT HEAVY CHAIN
(Mus
musculus) 		4 / 6 ASN B  77
ALA B  24
PRO B  53
TYR B  27
 None
 1.15A 5umd2-4cadB:
undetectable
5umdF-4cadB:
undetectable		 5umd2-4cadB:
15.38
5umdF-4cadB:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4cad RAS AND A-FACTOR
CONVERTING ENZYME 1,
RCE1
(Methanococcus
maripaludis) 		4 / 5 PHE C 165
PHE C 149
LEU C 158
PHE C 266
 None
 1.16A 5wauC-4cadC:
undetectable
5wauJ-4cadC:
undetectable		 5wauC-4cadC:
24.48
5wauJ-4cadC:
12.82