SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cag'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN
(Bacillus
licheniformis) 		5 / 12 LEU A 469
GLY A 434
ASP A 427
ALA A 435
ALA A 425
 None
CA  A 604 (-4.4A)
CA  A 604 (-3.2A)
None
None
 1.22A 2br4B-4cagA:
undetectable		 2br4B-4cagA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN
(Bacillus
licheniformis) 		5 / 12 LEU A 469
GLY A 434
ASP A 427
ALA A 435
ALA A 425
 None
CA  A 604 (-4.4A)
CA  A 604 (-3.2A)
None
None
 1.09A 2br4F-4cagA:
undetectable		 2br4F-4cagA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN
(Bacillus
licheniformis) 		5 / 10 THR A 507
ALA A 506
ALA A 500
VAL A 522
GLY A 462
 None
 0.91A 2f16K-4cagA:
undetectable
2f16L-4cagA:
undetectable		 2f16K-4cagA:
16.92
2f16L-4cagA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN
(Bacillus
licheniformis) 		5 / 10 THR A 507
ALA A 506
ALA A 500
VAL A 522
GLY A 462
 None
 0.92A 2f16Y-4cagA:
undetectable
2f16Z-4cagA:
undetectable		 2f16Y-4cagA:
16.92
2f16Z-4cagA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN
(Bacillus
licheniformis) 		4 / 4 SER A  30
GLY A 516
HIS A 543
ASP A 427
 None
CA  A 610 ( 4.4A)
None
CA  A 604 (-3.2A)
 1.39A 2oxtC-4cagA:
undetectable		 2oxtC-4cagA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN
(Bacillus
licheniformis) 		3 / 3 ASP A 207
ASN A 178
THR A 186
 None
 0.74A 2pymB-4cagA:
undetectable		 2pymB-4cagA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN
(Bacillus
licheniformis) 		4 / 6 HIS A 374
ALA A 426
ALA A 435
PHE A 402
 None
 0.98A 2xfhA-4cagA:
undetectable		 2xfhA-4cagA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN
(Bacillus
licheniformis) 		4 / 6 THR A 239
ILE A 173
LEU A 175
THR A 205
 None
 0.75A 3deuB-4cagA:
undetectable		 3deuB-4cagA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_2
(ADENOSYLHOMOCYSTEINA
SE)		 4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN
(Bacillus
licheniformis) 		4 / 5 THR A  61
GLU A  37
THR A  36
HIS A 550
 None
 1.34A 3glqA-4cagA:
undetectable		 3glqA-4cagA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_2
(ADENOSYLHOMOCYSTEINA
SE)		 4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN
(Bacillus
licheniformis) 		4 / 5 THR A  61
GLU A  37
THR A  36
HIS A 550
 None
 1.39A 3glqB-4cagA:
undetectable		 3glqB-4cagA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN
(Bacillus
licheniformis) 		5 / 12 THR A 507
ALA A 506
ALA A 500
VAL A 522
GLY A 462
 None
 0.86A 3mg0Y-4cagA:
undetectable
3mg0Z-4cagA:
undetectable		 3mg0Y-4cagA:
16.92
3mg0Z-4cagA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN
(Bacillus
licheniformis) 		4 / 5 THR A  61
GLU A  37
THR A  36
HIS A 550
 None
 1.40A 3n58A-4cagA:
undetectable		 3n58A-4cagA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN
(Bacillus
licheniformis) 		3 / 3 TYR A 484
ASP A 427
ASP A 379
 None
CA  A 604 (-3.2A)
None
 0.91A 3ou6B-4cagA:
undetectable		 3ou6B-4cagA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN
(Bacillus
licheniformis) 		3 / 3 LEU A 335
MET A 353
ASP A 356
 None
None
CA  A 606 (-2.5A)
 0.78A 3v5wA-4cagA:
undetectable		 3v5wA-4cagA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN
(Bacillus
licheniformis) 		4 / 7 PHE A 193
VAL A 279
ARG A 555
GLU A 200
 None
None
None
CA  A 605 (-2.0A)
 1.13A 4a97H-4cagA:
undetectable		 4a97H-4cagA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN
(Bacillus
licheniformis) 		3 / 3 TYR A 296
HIS A 184
ARG A 274
 GOL  A 611 (-4.6A)
None
GOL  A 611 ( 4.2A)
 1.15A 4htfA-4cagA:
undetectable		 4htfA-4cagA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN
(Bacillus
licheniformis) 		5 / 12 GLY A 423
ALA A 372
PHE A 388
PHE A 402
LEU A 378
 None
 1.19A 4hytA-4cagA:
undetectable		 4hytA-4cagA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN
(Bacillus
licheniformis) 		5 / 12 GLY A 423
ALA A 372
PHE A 388
PHE A 402
LEU A 378
 None
 1.19A 4hytC-4cagA:
undetectable		 4hytC-4cagA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O79_B_ASCB303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN
(Bacillus
licheniformis) 		4 / 6 TYR A 254
ARG A 293
ALA A 292
MET A 291
 None
 1.00A 4o79B-4cagA:
undetectable		 4o79B-4cagA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN
(Bacillus
licheniformis) 		4 / 6 TYR A 254
ARG A 293
ALA A 292
MET A 291
 None
 1.07A 4o7gB-4cagA:
undetectable		 4o7gB-4cagA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN
(Bacillus
licheniformis) 		3 / 3 ASN A 270
ASP A 148
ASP A 371
 None
GOL  A 611 ( 4.7A)
CA  A 601 ( 2.2A)
 0.65A 4obwD-4cagA:
undetectable		 4obwD-4cagA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN
(Bacillus
licheniformis) 		5 / 12 ALA A 124
ILE A 138
ILE A 534
LEU A 165
GLN A 134
 None
 1.19A 4r3aA-4cagA:
undetectable		 4r3aA-4cagA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN
(Bacillus
licheniformis) 		5 / 12 ALA A 559
ILE A 173
ALA A 277
ALA A 202
PHE A 193
 None
 0.84A 4v01A-4cagA:
undetectable		 4v01A-4cagA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN
(Bacillus
licheniformis) 		3 / 3 ARG A 519
ASP A 517
TRP A 518
 None
 0.88A 4xdqA-4cagA:
undetectable		 4xdqA-4cagA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN
(Bacillus
licheniformis) 		4 / 7 ARG A 258
VAL A 261
LEU A 232
SER A 233
 None
 0.96A 4zphA-4cagA:
undetectable
4zphB-4cagA:
undetectable		 4zphA-4cagA:
20.20
4zphB-4cagA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		 4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN
(Bacillus
licheniformis) 		3 / 3 THR A 365
SER A 364
TYR A 363
 None
 0.86A 5jsdA-4cagA:
undetectable		 5jsdA-4cagA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		 4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN
(Bacillus
licheniformis) 		3 / 3 THR A 365
SER A 364
TYR A 363
 None
 0.88A 5jsdB-4cagA:
undetectable		 5jsdB-4cagA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		 4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN
(Bacillus
licheniformis) 		3 / 3 THR A 365
SER A 364
TYR A 363
 None
 0.86A 5jsdC-4cagA:
undetectable		 5jsdC-4cagA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		 4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN
(Bacillus
licheniformis) 		3 / 3 THR A 365
SER A 364
TYR A 363
 None
 0.87A 5jseA-4cagA:
undetectable		 5jseA-4cagA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		 4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN
(Bacillus
licheniformis) 		3 / 3 THR A 365
SER A 364
TYR A 363
 None
 0.87A 5jseB-4cagA:
undetectable		 5jseB-4cagA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		 4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN
(Bacillus
licheniformis) 		3 / 3 THR A 365
SER A 364
TYR A 363
 None
 0.87A 5jseC-4cagA:
undetectable		 5jseC-4cagA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN
(Bacillus
licheniformis) 		5 / 12 ASP A 551
GLY A 572
ASN A 377
ALA A 405
VAL A 337
 None
None
CA  A 608 (-2.9A)
None
None
 1.42A 5kbwB-4cagA:
undetectable		 5kbwB-4cagA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN
(Bacillus
licheniformis) 		4 / 5 TYR A 363
ALA A 405
GLN A 389
THR A 375
 None
 1.38A 5n0wB-4cagA:
undetectable		 5n0wB-4cagA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN
(Bacillus
licheniformis) 		5 / 9 VAL A 272
GLY A 229
TYR A 185
ASP A 152
GLY A 153
 None
 1.36A 5zniA-4cagA:
undetectable		 5zniA-4cagA:
9.30