SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cbv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 4cbv COME
(Streptococcus
pneumoniae) 		3 / 3 GLU A  43
LYS A  38
VAL A  39
 None
 1.00A 1l2iA-4cbvA:
undetectable		 1l2iA-4cbvA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 4cbv COME
(Streptococcus
pneumoniae) 		4 / 8 ASN A 208
ILE A 158
TYR A 155
ARG A 197
 None
 1.42A 3ccfB-4cbvA:
undetectable		 3ccfB-4cbvA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 4cbv COME
(Streptococcus
pneumoniae) 		4 / 8 TYR A  55
TYR A  78
PHE A  42
ILE A  61
 None
 0.87A 3jz0B-4cbvA:
undetectable		 3jz0B-4cbvA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4cbv COME
(Streptococcus
pneumoniae) 		4 / 4 VAL A  71
PHE A  86
PHE A  56
VAL A   3
 None
 1.27A 3rv5C-4cbvA:
undetectable
3rv5D-4cbvA:
undetectable		 3rv5C-4cbvA:
17.27
3rv5D-4cbvA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 4cbv COME
(Streptococcus
pneumoniae) 		3 / 3 PHE A 142
ASP A 140
ARG A 197
 None
 0.88A 4eahF-4cbvA:
undetectable		 4eahF-4cbvA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 4cbv COME
(Streptococcus
pneumoniae) 		3 / 3 PHE A 142
ASP A 140
ARG A 197
 None
 0.88A 4eahG-4cbvA:
undetectable		 4eahG-4cbvA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 4cbv COME
(Streptococcus
pneumoniae) 		3 / 3 LEU A 133
LYS A 129
THR A 128
 None
 0.58A 4lj0A-4cbvA:
undetectable		 4lj0A-4cbvA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4cbv COME
(Streptococcus
pneumoniae) 		3 / 3 ASP A 157
LYS A 152
LEU A 132
 None
 1.05A 4ptjA-4cbvA:
undetectable		 4ptjA-4cbvA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 4cbv COME
(Streptococcus
pneumoniae) 		4 / 8 ILE A  84
ARG A  76
VAL A  71
ASP A  49
 None
 1.13A 5vlmF-4cbvA:
undetectable		 5vlmF-4cbvA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4cbv COME
(Streptococcus
pneumoniae) 		4 / 6 ARG A 217
LYS A 218
LEU A 220
LEU A 235
 None
 1.13A 5w97C-4cbvA:
undetectable
5w97J-4cbvA:
undetectable		 5w97C-4cbvA:
16.54
5w97J-4cbvA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 4cbv COME
(Streptococcus
pneumoniae) 		5 / 12 PRO A  30
ILE A  29
ILE A  31
THR A 128
ILE A 125
 None
 1.16A 6hlpA-4cbvA:
5.8		 6hlpA-4cbvA:
17.37