SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cbw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4cbw ACTIN, ALPHA
SKELETAL MUSCLE,
ACTIN
(Plasmodium
berghei;
synthetic
construct) 		4 / 5 GLY A  24
GLN A   7
VAL A  10
SER A 349
 None
 1.34A 1zzuA-4cbwA:
undetectable		 1zzuA-4cbwA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 4cbw ACTIN, ALPHA
SKELETAL MUSCLE,
ACTIN
(Plasmodium
berghei;
synthetic
construct) 		5 / 12 ALA A   8
GLN A   7
TRP A 357
LEU A 347
THR A 107
 None
 1.31A 2oaxC-4cbwA:
undetectable		 2oaxC-4cbwA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 4cbw ACTIN, ALPHA
SKELETAL MUSCLE,
ACTIN
(Plasmodium
berghei;
synthetic
construct) 		5 / 12 ALA A   8
GLN A   7
TRP A 357
LEU A 347
THR A 107
 None
 1.38A 2oaxF-4cbwA:
undetectable		 2oaxF-4cbwA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4cbw ACTIN, ALPHA
SKELETAL MUSCLE,
ACTIN
(Plasmodium
berghei;
synthetic
construct) 		5 / 12 GLY A 183
GLY A 159
GLY A  16
LEU A 181
LYS A 207
 ATP  A1379 (-3.6A)
ATP  A1379 (-3.7A)
ATP  A1379 (-3.4A)
None
None
 0.94A 2oxtC-4cbwA:
undetectable		 2oxtC-4cbwA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4cbw ACTIN, ALPHA
SKELETAL MUSCLE,
ACTIN
(Plasmodium
berghei;
synthetic
construct) 		4 / 7 ILE A  35
GLY A  56
PHE A  32
ILE A  86
 None
 0.87A 2y7wC-4cbwA:
undetectable		 2y7wC-4cbwA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4cbw ACTIN, ALPHA
SKELETAL MUSCLE,
ACTIN
(Plasmodium
berghei;
synthetic
construct) 		5 / 12 SER A  30
ALA A  20
VAL A 104
ASN A  13
VAL A  18
 None
 1.10A 3f8wA-4cbwA:
undetectable		 3f8wA-4cbwA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 4cbw ACTIN, ALPHA
SKELETAL MUSCLE,
ACTIN
(Plasmodium
berghei;
synthetic
construct) 		4 / 7 VAL A 140
LEU A 294
LEU A 154
ILE A 137
 None
 0.89A 3gp0A-4cbwA:
undetectable		 3gp0A-4cbwA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 4cbw ACTIN, ALPHA
SKELETAL MUSCLE,
ACTIN
(Plasmodium
berghei;
synthetic
construct) 		4 / 7 VAL A 140
LEU A 294
LEU A 300
ILE A 137
 None
 0.96A 3gp0A-4cbwA:
undetectable		 3gp0A-4cbwA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4cbw ACTIN, ALPHA
SKELETAL MUSCLE,
ACTIN
(Plasmodium
berghei;
synthetic
construct) 		4 / 7 MET A 124
ILE A  11
VAL A  77
TRP A  80
 None
 1.24A 4f4dA-4cbwA:
undetectable		 4f4dA-4cbwA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4cbw ACTIN, ALPHA
SKELETAL MUSCLE,
ACTIN
(Plasmodium
berghei;
synthetic
construct) 		4 / 8 MET A 124
ILE A  11
VAL A  77
TRP A  80
 None
 1.26A 4f4dB-4cbwA:
undetectable		 4f4dB-4cbwA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 4cbw ACTIN, ALPHA
SKELETAL MUSCLE,
ACTIN
(Plasmodium
berghei;
synthetic
construct) 		4 / 7 ALA A 261
PRO A 259
LEU A 181
LEU A 268
 None
 0.89A 4iomA-4cbwA:
2.5		 4iomA-4cbwA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4cbw ACTIN, ALPHA
SKELETAL MUSCLE,
ACTIN
(Plasmodium
berghei;
synthetic
construct) 		3 / 3 PRO A 110
LEU A 111
HIS A 174
 None
 0.63A 4pevA-4cbwA:
undetectable		 4pevA-4cbwA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 4cbw ACTIN, ALPHA
SKELETAL MUSCLE,
ACTIN
(Plasmodium
berghei;
synthetic
construct) 		4 / 5 GLY A 159
ARG A 184
GLY A 183
GLU A 188
 ATP  A1379 (-3.7A)
None
ATP  A1379 (-3.6A)
None
 1.24A 4z2eB-4cbwA:
undetectable
4z2eC-4cbwA:
2.7		 4z2eB-4cbwA:
21.53
4z2eC-4cbwA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 4cbw ACTIN, ALPHA
SKELETAL MUSCLE,
ACTIN
(Plasmodium
berghei;
synthetic
construct) 		4 / 6 LYS A 337
ASP A 155
TYR A 338
PRO A  28
 ATP  A1379 ( 3.8A)
CA  A1377 ( 4.3A)
None
None
 1.36A 5bmvB-4cbwA:
undetectable		 5bmvB-4cbwA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 4cbw ACTIN, ALPHA
SKELETAL MUSCLE,
ACTIN
(Plasmodium
berghei;
synthetic
construct) 		3 / 3 GLN A 138
THR A 107
ASP A  12
 CA  A1377 ( 4.3A)
None
CA  A1377 ( 4.7A)
 0.92A 5k9dA-4cbwA:
undetectable		 5k9dA-4cbwA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 4cbw ACTIN, ALPHA
SKELETAL MUSCLE,
ACTIN
(Plasmodium
berghei;
synthetic
construct) 		5 / 12 THR A 278
ILE A 275
LEU A 179
ASP A 185
LEU A 268
 None
 1.19A 6ie8A-4cbwA:
undetectable		 6ie8A-4cbwA:
21.08