SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cbx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 4cbx ACTIN-2
(Plasmodium
berghei) 		4 / 8 ARG A 147
SER A 145
VAL A 299
ASN A 296
 None
None
None
NA  A1377 (-3.1A)
 1.17A 1hwkA-4cbxA:
undetectable		 1hwkA-4cbxA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 4cbx ACTIN-2
(Plasmodium
berghei) 		4 / 8 ARG A 147
SER A 145
VAL A 299
ASN A 296
 None
None
None
NA  A1377 (-3.1A)
 1.20A 1hwkC-4cbxA:
undetectable		 1hwkC-4cbxA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 4cbx ACTIN-2
(Plasmodium
berghei) 		4 / 8 ARG A 147
SER A 145
VAL A 299
ASN A 296
 None
None
None
NA  A1377 (-3.1A)
 1.19A 1hwkD-4cbxA:
undetectable		 1hwkD-4cbxA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 4cbx ACTIN-2
(Plasmodium
berghei) 		4 / 8 SER A  14
ASP A 179
LEU A 110
PRO A 109
 ATP  A1374 (-2.6A)
None
None
None
 1.14A 3jq7B-4cbxA:
undetectable		 3jq7B-4cbxA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 4cbx ACTIN-2
(Plasmodium
berghei) 		3 / 3 ASP A 184
ARG A 183
TYR A 187
 None
 0.98A 5a7mA-4cbxA:
undetectable		 5a7mA-4cbxA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 4cbx ACTIN-2
(Plasmodium
berghei) 		3 / 3 ASP A 184
ARG A 183
TYR A 187
 None
 0.98A 5a7mB-4cbxA:
undetectable		 5a7mB-4cbxA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 4cbx ACTIN-2
(Plasmodium
berghei) 		3 / 3 PRO A 102
ILE A 136
SER A   5
 None
 0.81A 5fsaA-4cbxA:
undetectable		 5fsaA-4cbxA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 4cbx ACTIN-2
(Plasmodium
berghei) 		3 / 3 GLN A 137
THR A 106
ASP A  11
 CA  A1378 ( 4.2A)
None
CA  A1378 ( 4.6A)
 0.88A 5k9dA-4cbxA:
undetectable		 5k9dA-4cbxA:
22.48