SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cby'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		4 / 5 HIS A 803
LEU A 943
SER A 931
GLY A 975
 KEE  A2033 (-4.0A)
None
None
KEE  A2033 ( 4.9A)
 1.01A 1a4lB-4cbyA:
undetectable		 1a4lB-4cbyA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C3S_A_SHHA952_1
(HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN))		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		8 / 11 PRO A 676
HIS A 802
HIS A 803
ASP A 840
HIS A 842
PHE A 871
ASP A 934
LEU A 943
 None
KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
None
 0.68A 1c3sA-4cbyA:
39.8		 1c3sA-4cbyA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C3S_A_SHHA952_1
(HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN))		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		8 / 11 PRO A 676
HIS A 802
HIS A 803
PHE A 812
ASP A 840
HIS A 842
PHE A 871
ASP A 934
 None
KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 (-4.2A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
 0.62A 1c3sA-4cbyA:
39.8		 1c3sA-4cbyA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 11 PRO A 727
VAL A 756
VAL A 754
GLY A 755
LEU A 722
 None
 1.48A 1lwcA-4cbyA:
undetectable		 1lwcA-4cbyA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 9 GLY A 811
PRO A 676
GLY A 974
GLY A 975
ASP A 934
 KEE  A2033 ( 4.2A)
None
KEE  A2033 (-3.6A)
KEE  A2033 ( 4.9A)
ZN  A2034 ( 2.4A)
 1.08A 1mxdA-4cbyA:
undetectable		 1mxdA-4cbyA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 11 GLY A 811
PRO A 676
GLY A 974
GLY A 975
ASP A 934
 KEE  A2033 ( 4.2A)
None
KEE  A2033 (-3.6A)
KEE  A2033 ( 4.9A)
ZN  A2034 ( 2.4A)
 1.08A 1mxgA-4cbyA:
undetectable		 1mxgA-4cbyA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		7 / 12 HIS A 802
HIS A 803
GLY A 811
ASP A 840
HIS A 842
PHE A 871
ASP A 934
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 ( 4.2A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
 0.39A 1t69A-4cbyA:
40.0		 1t69A-4cbyA:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		7 / 12 HIS A 802
HIS A 803
GLY A 811
PHE A 812
ASP A 840
PHE A 871
ASP A 934
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 ( 4.2A)
KEE  A2033 (-4.2A)
ZN  A2034 (-2.0A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
 0.69A 1t69A-4cbyA:
40.0		 1t69A-4cbyA:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		4 / 8 ASN A 816
HIS A 715
ARG A 772
VAL A 775
 None
 1.33A 1u1jA-4cbyA:
undetectable		 1u1jA-4cbyA:
18.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 11 HIS A 802
HIS A 803
ASP A 840
ASP A 934
GLY A 932
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
ZN  A2034 (-2.0A)
ZN  A2034 ( 2.4A)
None
 1.20A 1zz1A-4cbyA:
47.0		 1zz1A-4cbyA:
32.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		7 / 11 HIS A 802
HIS A 803
ASP A 840
HIS A 842
PHE A 871
ASP A 934
GLY A 974
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
KEE  A2033 (-3.6A)
 0.48A 1zz1A-4cbyA:
47.0		 1zz1A-4cbyA:
32.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		7 / 11 HIS A 802
HIS A 803
PHE A 812
HIS A 842
PHE A 871
ASP A 934
GLY A 974
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 (-4.2A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
KEE  A2033 (-3.6A)
 0.73A 1zz1A-4cbyA:
47.0		 1zz1A-4cbyA:
32.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		7 / 12 HIS A 802
HIS A 803
ASP A 840
HIS A 842
PHE A 871
ASP A 934
GLY A 974
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
KEE  A2033 (-3.6A)
 0.39A 1zz1B-4cbyA:
47.1
1zz1C-4cbyA:
47.2		 1zz1B-4cbyA:
32.83
1zz1C-4cbyA:
32.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		6 / 12 HIS A 802
HIS A 803
PHE A 812
HIS A 842
PHE A 871
GLY A 974
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 (-4.2A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
KEE  A2033 (-3.6A)
 0.73A 1zz1B-4cbyA:
47.1
1zz1C-4cbyA:
47.2		 1zz1B-4cbyA:
32.83
1zz1C-4cbyA:
32.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		8 / 12 HIS A 802
HIS A 803
GLY A 811
ASP A 840
HIS A 842
PHE A 871
ASP A 934
GLY A 974
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 ( 4.2A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
KEE  A2033 (-3.6A)
 0.45A 1zz1C-4cbyA:
47.2		 1zz1C-4cbyA:
32.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_D_SHHD2752_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		6 / 9 HIS A 802
HIS A 803
ASP A 840
HIS A 842
PHE A 871
ASP A 934
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
 0.44A 1zz1D-4cbyA:
47.1		 1zz1D-4cbyA:
32.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_D_SHHD2752_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 9 HIS A 802
HIS A 803
PHE A 812
HIS A 842
PHE A 871
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 (-4.2A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
 0.75A 1zz1D-4cbyA:
47.1		 1zz1D-4cbyA:
32.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 12 THR A 713
GLN A 827
ILE A 834
VAL A 926
VAL A 782
 None
 0.96A 2g72B-4cbyA:
undetectable		 2g72B-4cbyA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 9 GLY A 932
SER A 931
LEU A 970
ASP A 838
ASP A 840
 None
None
None
NA  A2036 (-2.7A)
ZN  A2034 (-2.0A)
 1.32A 2j2pB-4cbyA:
undetectable
2j2pC-4cbyA:
undetectable		 2j2pB-4cbyA:
19.33
2j2pC-4cbyA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 12 ASP A 840
GLY A 974
GLY A 975
ALA A 980
GLY A 944
 ZN  A2034 (-2.0A)
KEE  A2033 (-3.6A)
KEE  A2033 ( 4.9A)
None
None
 1.05A 2pkkA-4cbyA:
2.1		 2pkkA-4cbyA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 12 PHE A 851
PRO A 924
ALA A 923
ALA A 819
ALA A 821
 None
 1.19A 2x2nA-4cbyA:
undetectable		 2x2nA-4cbyA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 12 PHE A 851
PRO A 924
ALA A 923
ALA A 819
ALA A 821
 None
 1.16A 2x2nB-4cbyA:
undetectable		 2x2nB-4cbyA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		4 / 6 GLN A 959
ALA A 905
ALA A 909
THR A 913
 None
 0.49A 2xfhA-4cbyA:
undetectable		 2xfhA-4cbyA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		3 / 3 MET A 662
GLU A 677
ASP A 934
 None
None
ZN  A2034 ( 2.4A)
 1.07A 3a25A-4cbyA:
3.4		 3a25A-4cbyA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 11 PHE A 794
SER A 985
CYH A 982
ILE A 682
SER A 687
 None
 1.23A 3a9eB-4cbyA:
undetectable		 3a9eB-4cbyA:
22.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 5 HIS A 802
HIS A 803
ASP A 840
HIS A 842
ASP A 934
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
ZN  A2034 ( 2.4A)
 0.21A 3c0zA-4cbyA:
62.9		 3c0zA-4cbyA:
69.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		8 / 8 HIS A 802
HIS A 803
PHE A 812
ASP A 840
HIS A 842
PHE A 871
ASP A 934
GLY A 974
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 (-4.2A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
KEE  A2033 (-3.6A)
 0.56A 3c0zB-4cbyA:
61.7		 3c0zB-4cbyA:
69.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		4 / 8 PHE A 871
ASP A 934
PHE A 812
ASP A 840
 KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
KEE  A2033 (-4.2A)
ZN  A2034 (-2.0A)
 0.90A 3c0zB-4cbyA:
61.7		 3c0zB-4cbyA:
69.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 6 HIS A 802
HIS A 803
ASP A 840
HIS A 842
ASP A 934
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
ZN  A2034 ( 2.4A)
 0.19A 3c0zC-4cbyA:
61.6		 3c0zC-4cbyA:
69.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 11 THR A 957
LEU A 992
ASN A 792
SER A 990
LEU A 970
 None
 1.40A 3ndvA-4cbyA:
undetectable
3ndvB-4cbyA:
undetectable		 3ndvA-4cbyA:
23.72
3ndvB-4cbyA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 11 LEU A 970
THR A 957
LEU A 992
ASN A 792
SER A 990
 None
 1.39A 3ndvA-4cbyA:
undetectable
3ndvB-4cbyA:
undetectable		 3ndvA-4cbyA:
23.72
3ndvB-4cbyA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 11 THR A 957
LEU A 992
ASN A 792
SER A 990
LEU A 970
 None
 1.39A 3ndvC-4cbyA:
undetectable
3ndvD-4cbyA:
undetectable		 3ndvC-4cbyA:
23.72
3ndvD-4cbyA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 11 LEU A 970
THR A 957
LEU A 992
ASN A 792
SER A 990
 None
 1.40A 3ndvC-4cbyA:
undetectable
3ndvD-4cbyA:
undetectable		 3ndvC-4cbyA:
23.72
3ndvD-4cbyA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_A_SHHA700_1
(HISTONE DEACETYLASE
8)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		6 / 10 HIS A 802
HIS A 803
ASP A 840
HIS A 842
ASP A 934
GLY A 974
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
ZN  A2034 ( 2.4A)
KEE  A2033 (-3.6A)
 0.26A 4bz6A-4cbyA:
39.2		 4bz6A-4cbyA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_A_SHHA700_1
(HISTONE DEACETYLASE
8)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 10 HIS A 802
HIS A 803
HIS A 842
ASP A 934
GLY A 932
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
ZN  A2034 (-3.2A)
ZN  A2034 ( 2.4A)
None
 1.26A 4bz6A-4cbyA:
39.2		 4bz6A-4cbyA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		7 / 12 HIS A 802
HIS A 803
ASP A 840
HIS A 842
PHE A 871
ASP A 934
GLY A 974
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
KEE  A2033 (-3.6A)
 0.30A 4bz6A-4cbyA:
39.2
4bz6B-4cbyA:
39.1		 4bz6A-4cbyA:
24.12
4bz6B-4cbyA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 12 HIS A 802
HIS A 803
HIS A 842
ASP A 934
GLY A 932
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
ZN  A2034 (-3.2A)
ZN  A2034 ( 2.4A)
None
 1.25A 4bz6A-4cbyA:
39.2
4bz6B-4cbyA:
39.1		 4bz6A-4cbyA:
24.12
4bz6B-4cbyA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		8 / 12 HIS A 802
HIS A 803
GLY A 811
ASP A 840
HIS A 842
PHE A 871
ASP A 934
GLY A 974
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 ( 4.2A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
KEE  A2033 (-3.6A)
 0.36A 4bz6C-4cbyA:
39.2		 4bz6C-4cbyA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 12 HIS A 802
HIS A 803
HIS A 842
ASP A 934
GLY A 932
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
ZN  A2034 (-3.2A)
ZN  A2034 ( 2.4A)
None
 1.24A 4bz6C-4cbyA:
39.2		 4bz6C-4cbyA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_D_SHHD700_1
(HISTONE DEACETYLASE
8)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		6 / 10 HIS A 802
HIS A 803
ASP A 840
HIS A 842
ASP A 934
GLY A 974
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
ZN  A2034 ( 2.4A)
KEE  A2033 (-3.6A)
 0.26A 4bz6D-4cbyA:
39.5		 4bz6D-4cbyA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_D_SHHD700_1
(HISTONE DEACETYLASE
8)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 10 HIS A 802
HIS A 803
HIS A 842
ASP A 934
GLY A 932
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
ZN  A2034 (-3.2A)
ZN  A2034 ( 2.4A)
None
 1.25A 4bz6D-4cbyA:
39.5		 4bz6D-4cbyA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		8 / 12 PRO A 676
HIS A 802
HIS A 803
GLY A 811
ASP A 840
HIS A 842
ASP A 934
GLY A 974
 None
KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 ( 4.2A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
ZN  A2034 ( 2.4A)
KEE  A2033 (-3.6A)
 0.38A 4lxzA-4cbyA:
42.4		 4lxzA-4cbyA:
29.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		7 / 12 PRO A 676
HIS A 802
HIS A 803
GLY A 811
PHE A 812
ASP A 840
GLY A 974
 None
KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 ( 4.2A)
KEE  A2033 (-4.2A)
ZN  A2034 (-2.0A)
KEE  A2033 (-3.6A)
 0.57A 4lxzA-4cbyA:
42.4		 4lxzA-4cbyA:
29.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		7 / 11 PRO A 676
HIS A 802
HIS A 803
ASP A 840
HIS A 842
ASP A 934
GLY A 974
 None
KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
ZN  A2034 ( 2.4A)
KEE  A2033 (-3.6A)
 0.40A 4lxzB-4cbyA:
42.4		 4lxzB-4cbyA:
29.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		6 / 11 PRO A 676
HIS A 802
HIS A 803
PHE A 812
ASP A 840
GLY A 974
 None
KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 (-4.2A)
ZN  A2034 (-2.0A)
KEE  A2033 (-3.6A)
 0.62A 4lxzB-4cbyA:
42.4		 4lxzB-4cbyA:
29.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 11 PRO A 676
HIS A 803
HIS A 842
ASP A 934
GLY A 974
 None
KEE  A2033 (-4.0A)
ZN  A2034 (-3.2A)
ZN  A2034 ( 2.4A)
KEE  A2033 (-3.6A)
 1.38A 4lxzB-4cbyA:
42.4		 4lxzB-4cbyA:
29.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		9 / 12 PRO A 676
HIS A 802
HIS A 803
GLY A 811
ASP A 840
HIS A 842
PHE A 871
ASP A 934
GLY A 974
 None
KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 ( 4.2A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
KEE  A2033 (-3.6A)
 0.44A 4lxzC-4cbyA:
42.4		 4lxzC-4cbyA:
29.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		8 / 12 PRO A 676
HIS A 802
HIS A 803
GLY A 811
PHE A 812
ASP A 840
PHE A 871
GLY A 974
 None
KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 ( 4.2A)
KEE  A2033 (-4.2A)
ZN  A2034 (-2.0A)
KEE  A2033 (-3.8A)
KEE  A2033 (-3.6A)
 0.61A 4lxzC-4cbyA:
42.4		 4lxzC-4cbyA:
29.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 12 ILE A 685
ALA A 984
LEU A 970
ALA A 971
LEU A 656
 None
 1.03A 4psyA-4cbyA:
undetectable		 4psyA-4cbyA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		8 / 12 HIS A 802
HIS A 803
GLY A 811
ASP A 840
HIS A 842
PHE A 871
ASP A 934
GLY A 974
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 ( 4.2A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
KEE  A2033 (-3.6A)
 0.36A 4qa0A-4cbyA:
40.0		 4qa0A-4cbyA:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		7 / 12 HIS A 802
HIS A 803
GLY A 811
PHE A 812
ASP A 840
PHE A 871
GLY A 974
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 ( 4.2A)
KEE  A2033 (-4.2A)
ZN  A2034 (-2.0A)
KEE  A2033 (-3.8A)
KEE  A2033 (-3.6A)
 0.68A 4qa0A-4cbyA:
40.0		 4qa0A-4cbyA:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		7 / 11 HIS A 802
HIS A 803
ASP A 840
HIS A 842
PHE A 871
ASP A 934
GLY A 974
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
KEE  A2033 (-3.6A)
 0.41A 4qa0B-4cbyA:
40.0		 4qa0B-4cbyA:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		6 / 11 HIS A 802
HIS A 803
PHE A 812
ASP A 840
PHE A 871
GLY A 974
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 (-4.2A)
ZN  A2034 (-2.0A)
KEE  A2033 (-3.8A)
KEE  A2033 (-3.6A)
 0.69A 4qa0B-4cbyA:
40.0		 4qa0B-4cbyA:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		9 / 12 HIS A 802
HIS A 803
GLY A 811
PHE A 812
ASP A 840
HIS A 842
PHE A 871
ASP A 934
GLY A 974
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 ( 4.2A)
KEE  A2033 (-4.2A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
KEE  A2033 (-3.6A)
 0.60A 4qa2A-4cbyA:
40.0		 4qa2A-4cbyA:
28.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		9 / 12 HIS A 802
HIS A 803
GLY A 811
PHE A 812
ASP A 840
HIS A 842
PHE A 871
ASP A 934
GLY A 974
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 ( 4.2A)
KEE  A2033 (-4.2A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
KEE  A2033 (-3.6A)
 0.58A 4qa2B-4cbyA:
40.2		 4qa2B-4cbyA:
28.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 12 HIS A 802
HIS A 803
HIS A 842
ASP A 934
GLY A 932
 KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
ZN  A2034 (-3.2A)
ZN  A2034 ( 2.4A)
None
 1.24A 4qa2B-4cbyA:
40.2		 4qa2B-4cbyA:
28.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 12 ALA A 935
LEU A 948
ALA A 893
ASN A1010
GLY A 945
 None
 1.00A 4r3aB-4cbyA:
undetectable		 4r3aB-4cbyA:
21.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		9 / 12 PRO A 676
HIS A 802
HIS A 803
GLY A 811
ASP A 840
HIS A 842
PHE A 871
ASP A 934
LEU A 943
 None
KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 ( 4.2A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
None
 0.58A 5eeiA-4cbyA:
55.0		 5eeiA-4cbyA:
43.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		6 / 12 PRO A 676
HIS A 802
HIS A 803
GLY A 811
PHE A 812
PHE A 871
 None
KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 ( 4.2A)
KEE  A2033 (-4.2A)
KEE  A2033 (-3.8A)
 0.63A 5eeiA-4cbyA:
55.0		 5eeiA-4cbyA:
43.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 12 PRO A 676
HIS A 803
HIS A 842
ASP A 934
LEU A 943
 None
KEE  A2033 (-4.0A)
ZN  A2034 (-3.2A)
ZN  A2034 ( 2.4A)
None
 1.28A 5eeiA-4cbyA:
55.0		 5eeiA-4cbyA:
43.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		9 / 12 PRO A 676
HIS A 802
HIS A 803
GLY A 811
ASP A 840
HIS A 842
PHE A 871
ASP A 934
LEU A 943
 None
KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 ( 4.2A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
None
 0.60A 5eeiB-4cbyA:
55.3		 5eeiB-4cbyA:
43.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		6 / 12 PRO A 676
HIS A 802
HIS A 803
GLY A 811
PHE A 812
PHE A 871
 None
KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 ( 4.2A)
KEE  A2033 (-4.2A)
KEE  A2033 (-3.8A)
 0.64A 5eeiB-4cbyA:
55.3		 5eeiB-4cbyA:
43.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 12 PRO A 676
HIS A 803
HIS A 842
ASP A 934
LEU A 943
 None
KEE  A2033 (-4.0A)
ZN  A2034 (-3.2A)
ZN  A2034 ( 2.4A)
None
 1.30A 5eeiB-4cbyA:
55.3		 5eeiB-4cbyA:
43.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 12 HIS A 802
ASP A 840
HIS A 842
ASP A 934
GLY A 932
 KEE  A2033 (-3.8A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
ZN  A2034 ( 2.4A)
None
 1.24A 5eenA-4cbyA:
55.5		 5eenA-4cbyA:
43.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		8 / 12 PRO A 676
HIS A 802
HIS A 803
ASP A 840
HIS A 842
PHE A 871
ASP A 934
GLY A 974
 None
KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
KEE  A2033 (-3.6A)
 0.39A 5eenA-4cbyA:
55.5		 5eenA-4cbyA:
43.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		7 / 12 PRO A 676
HIS A 802
HIS A 803
PHE A 812
ASP A 840
PHE A 871
GLY A 974
 None
KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 (-4.2A)
ZN  A2034 (-2.0A)
KEE  A2033 (-3.8A)
KEE  A2033 (-3.6A)
 0.65A 5eenA-4cbyA:
55.5		 5eenA-4cbyA:
43.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		8 / 12 PRO A 676
HIS A 802
HIS A 803
ASP A 840
HIS A 842
PHE A 871
ASP A 934
LEU A 943
 None
KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
None
 0.58A 5eenB-4cbyA:
55.0		 5eenB-4cbyA:
43.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		6 / 12 PRO A 676
HIS A 802
HIS A 803
PHE A 812
PHE A 871
LEU A 943
 None
KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 (-4.2A)
KEE  A2033 (-3.8A)
None
 0.84A 5eenB-4cbyA:
55.0		 5eenB-4cbyA:
43.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 12 PRO A 676
HIS A 803
HIS A 842
ASP A 934
LEU A 943
 None
KEE  A2033 (-4.0A)
ZN  A2034 (-3.2A)
ZN  A2034 ( 2.4A)
None
 1.32A 5eenB-4cbyA:
55.0		 5eenB-4cbyA:
43.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF8_A_LBHA2004_1
(HDAC6 PROTEIN)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		7 / 12 PRO A 676
HIS A 802
HIS A 803
ASP A 840
HIS A 842
PHE A 871
ASP A 934
 None
KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
 0.37A 5ef8A-4cbyA:
55.2		 5ef8A-4cbyA:
43.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF8_A_LBHA2004_1
(HDAC6 PROTEIN)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		6 / 12 PRO A 676
HIS A 802
HIS A 803
PHE A 812
ASP A 840
PHE A 871
 None
KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 (-4.2A)
ZN  A2034 (-2.0A)
KEE  A2033 (-3.8A)
 0.66A 5ef8A-4cbyA:
55.2		 5ef8A-4cbyA:
43.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		8 / 12 PRO A 676
HIS A 802
HIS A 803
ASP A 840
HIS A 842
PHE A 871
ASP A 934
LEU A 943
 None
KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
ZN  A2034 (-2.0A)
ZN  A2034 (-3.2A)
KEE  A2033 (-3.8A)
ZN  A2034 ( 2.4A)
None
 0.55A 5ef8B-4cbyA:
55.0		 5ef8B-4cbyA:
43.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		7 / 12 PRO A 676
HIS A 802
HIS A 803
PHE A 812
ASP A 840
PHE A 871
LEU A 943
 None
KEE  A2033 (-3.8A)
KEE  A2033 (-4.0A)
KEE  A2033 (-4.2A)
ZN  A2034 (-2.0A)
KEE  A2033 (-3.8A)
None
 0.78A 5ef8B-4cbyA:
55.0		 5ef8B-4cbyA:
43.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 12 PRO A 676
HIS A 803
HIS A 842
ASP A 934
LEU A 943
 None
KEE  A2033 (-4.0A)
ZN  A2034 (-3.2A)
ZN  A2034 ( 2.4A)
None
 1.27A 5ef8B-4cbyA:
55.0		 5ef8B-4cbyA:
43.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4cby HISTONE DEACETYLASE
4
(Homo
sapiens) 		5 / 11 PRO A 727
VAL A 756
VAL A 754
GLY A 755
LEU A 722
 None
 1.41A 5hbmA-4cbyA:
undetectable		 5hbmA-4cbyA:
19.41