SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cca'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 4cca SYNTAXIN-BINDING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ALA A 202
ILE A 232
LEU A 156
MET A 539
LEU A 169
 None
 1.09A 1dtlA-4ccaA:
undetectable		 1dtlA-4ccaA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1869_0
(FPRA)		 4cca SYNTAXIN-BINDING
PROTEIN 2
(Homo
sapiens) 		4 / 4 ASP A 402
HIS A 245
ARG A 405
GLU A 368
 None
 1.27A 1lqtA-4ccaA:
undetectable		 1lqtA-4ccaA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 4cca SYNTAXIN-BINDING
PROTEIN 2
(Homo
sapiens) 		3 / 3 ALA A 237
VAL A 240
TRP A 475
 None
 0.89A 1micA-4ccaA:
undetectable
1micB-4ccaA:
undetectable		 1micA-4ccaA:
2.66
1micB-4ccaA:
2.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		 4cca SYNTAXIN-BINDING
PROTEIN 2
(Homo
sapiens) 		4 / 5 THR A 153
SER A 568
PRO A 150
SER A 567
 None
 1.25A 2hdnA-4ccaA:
undetectable
2hdnB-4ccaA:
undetectable
2hdnD-4ccaA:
undetectable		 2hdnA-4ccaA:
5.00
2hdnB-4ccaA:
19.90
2hdnD-4ccaA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_D_TACD2888_1
(ELONGATION FACTOR
EF-TU)		 4cca SYNTAXIN-BINDING
PROTEIN 2
(Homo
sapiens) 		4 / 5 SER A 567
THR A 153
SER A 568
PRO A 150
 None
 1.24A 2hdnB-4ccaA:
undetectable
2hdnC-4ccaA:
undetectable
2hdnD-4ccaA:
undetectable		 2hdnB-4ccaA:
19.90
2hdnC-4ccaA:
5.00
2hdnD-4ccaA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 4cca SYNTAXIN-BINDING
PROTEIN 2
(Homo
sapiens) 		4 / 6 THR A 153
SER A 568
PRO A 150
SER A 567
 None
 1.24A 2hdnI-4ccaA:
undetectable
2hdnJ-4ccaA:
undetectable
2hdnL-4ccaA:
2.6		 2hdnI-4ccaA:
5.00
2hdnJ-4ccaA:
19.90
2hdnL-4ccaA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 4cca SYNTAXIN-BINDING
PROTEIN 2
(Homo
sapiens) 		4 / 6 SER A 567
THR A 153
SER A 568
PRO A 150
 None
 1.23A 2hdnJ-4ccaA:
undetectable
2hdnK-4ccaA:
undetectable
2hdnL-4ccaA:
2.6		 2hdnJ-4ccaA:
19.90
2hdnK-4ccaA:
5.00
2hdnL-4ccaA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4cca SYNTAXIN-BINDING
PROTEIN 2
(Homo
sapiens) 		4 / 7 SER A 567
GLN A 168
ILE A 176
SER A 152
 None
 1.11A 2xz5A-4ccaA:
undetectable
2xz5B-4ccaA:
undetectable		 2xz5A-4ccaA:
15.53
2xz5B-4ccaA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4cca SYNTAXIN-BINDING
PROTEIN 2
(Homo
sapiens) 		4 / 8 SER A 567
GLN A 168
ILE A 176
SER A 152
 None
 1.13A 2xz5B-4ccaA:
undetectable
2xz5E-4ccaA:
undetectable		 2xz5B-4ccaA:
15.53
2xz5E-4ccaA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4cca SYNTAXIN-BINDING
PROTEIN 2
(Homo
sapiens) 		5 / 11 LEU A 364
ILE A 389
VAL A 392
LEU A 393
VAL A 431
 None
 1.04A 3w67A-4ccaA:
undetectable		 3w67A-4ccaA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7G_A_ACTA514_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4cca SYNTAXIN-BINDING
PROTEIN 2
(Homo
sapiens) 		4 / 4 ALA A 397
VAL A 398
ASP A 395
LEU A 364
 None
 1.32A 4e7gA-4ccaA:
2.7		 4e7gA-4ccaA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K37_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4cca SYNTAXIN-BINDING
PROTEIN 2
(Homo
sapiens) 		5 / 11 TYR A 191
GLU A 170
LEU A 206
ILE A 189
LEU A 231
 None
 1.49A 4k37B-4ccaA:
undetectable		 4k37B-4ccaA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4cca SYNTAXIN-BINDING
PROTEIN 2
(Homo
sapiens) 		4 / 5 LEU A 114
ARG A 167
PRO A  36
SER A  37
 None
 1.48A 4kmmB-4ccaA:
3.8		 4kmmB-4ccaA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 4cca SYNTAXIN-BINDING
PROTEIN 2
(Homo
sapiens) 		4 / 6 ALA A 251
SER A 545
GLN A 369
SER A 473
 None
 1.16A 5c6pA-4ccaA:
undetectable		 5c6pA-4ccaA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4cca SYNTAXIN-BINDING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ASP A 255
GLU A 246
ALA A 543
SER A 545
LEU A 243
 None
 1.17A 5nd2B-4ccaA:
undetectable		 5nd2B-4ccaA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4cca SYNTAXIN-BINDING
PROTEIN 2
(Homo
sapiens) 		5 / 12 VAL A 478
GLU A 546
ALA A 237
ARG A 190
ARG A 235
 None
 1.38A 5nd2B-4ccaA:
undetectable		 5nd2B-4ccaA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4cca SYNTAXIN-BINDING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ASP A 255
GLU A 246
LEU A 444
ALA A 543
SER A 545
 None
 1.24A 5nd3B-4ccaA:
undetectable		 5nd3B-4ccaA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 4cca SYNTAXIN-BINDING
PROTEIN 2
(Homo
sapiens) 		4 / 6 ALA A 149
LEU A 147
TYR A 537
SER A 152
 None
 0.99A 5phhA-4ccaA:
undetectable		 5phhA-4ccaA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 4cca SYNTAXIN-BINDING
PROTEIN 2
(Homo
sapiens) 		4 / 6 TYR A 551
PRO A 139
LEU A 138
LEU A   6
 None
 1.15A 5tl8A-4ccaA:
undetectable		 5tl8A-4ccaA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 4cca SYNTAXIN-BINDING
PROTEIN 2
(Homo
sapiens) 		5 / 12 GLU A 224
LEU A   6
LEU A 183
LEU A 564
GLY A 559
 None
 0.92A 6b0cD-4ccaA:
undetectable		 6b0cD-4ccaA:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4cca SYNTAXIN-BINDING
PROTEIN 2
(Homo
sapiens) 		4 / 8 GLU A 562
VAL A   9
ARG A 292
GLN A 250
 None
 1.12A 6fbvD-4ccaA:
undetectable		 6fbvD-4ccaA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4cca SYNTAXIN-BINDING
PROTEIN 2
(Homo
sapiens) 		4 / 6 TYR A 410
ILE A 411
ARG A 414
ASP A 384
 None
 1.03A 6hu9m-4ccaA:
undetectable
6hu9q-4ccaA:
undetectable		 6hu9m-4ccaA:
20.83
6hu9q-4ccaA:
13.31