SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ccy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4ccy CARBOXYLESTERASE
YBFK
(Bacillus
subtilis) 		4 / 8 SER B  67
HIS B  62
TYR B  22
PHE B  18
 None
 1.22A 1eqbA-4ccyB:
undetectable
1eqbB-4ccyB:
undetectable		 1eqbA-4ccyB:
23.37
1eqbB-4ccyB:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4ccy CARBOXYLESTERASE
YBFK
(Bacillus
subtilis) 		4 / 8 TYR B  22
PHE B  18
SER B  67
HIS B  62
 None
 1.21A 1eqbA-4ccyB:
undetectable
1eqbB-4ccyB:
undetectable		 1eqbA-4ccyB:
23.37
1eqbB-4ccyB:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4ccy CARBOXYLESTERASE
YBFK
(Bacillus
subtilis) 		4 / 8 SER B  67
HIS B  62
TYR B  22
PHE B  18
 None
 1.23A 1eqbC-4ccyB:
undetectable
1eqbD-4ccyB:
undetectable		 1eqbC-4ccyB:
23.37
1eqbD-4ccyB:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4ccy CARBOXYLESTERASE
YBFK
(Bacillus
subtilis) 		4 / 8 TYR B  22
PHE B  18
SER B  67
HIS B  62
 None
 1.22A 1eqbC-4ccyB:
undetectable
1eqbD-4ccyB:
undetectable		 1eqbC-4ccyB:
23.37
1eqbD-4ccyB:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9J_H_TESH1010_1
(RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT LIGHT
CHAIN)		 4ccy CARBOXYLESTERASE
YBFK
(Bacillus
subtilis) 		5 / 11 SER B 130
TYR B 248
GLY B 273
LEU B 275
VAL B 166
 None
 1.34A 1i9jH-4ccyB:
undetectable
1i9jL-4ccyB:
undetectable		 1i9jH-4ccyB:
20.93
1i9jL-4ccyB:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 4ccy CARBOXYLESTERASE
YBFK
(Bacillus
subtilis) 		3 / 3 ALA B 171
VAL B 166
TRP B 185
 None
 0.76A 1micA-4ccyB:
undetectable
1micB-4ccyB:
undetectable		 1micA-4ccyB:
3.50
1micB-4ccyB:
3.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 4ccy CARBOXYLESTERASE
YBFK
(Bacillus
subtilis) 		5 / 10 ASP B  88
TRP B  71
GLY B 133
GLY B 132
SER B 130
 None
 1.12A 1w76B-4ccyB:
12.6		 1w76B-4ccyB:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 4ccy CARBOXYLESTERASE
YBFK
(Bacillus
subtilis) 		4 / 5 ILE B 201
SER B 213
ARG B 212
LEU B  65
 None
 1.07A 1y0xX-4ccyB:
undetectable		 1y0xX-4ccyB:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 4ccy CARBOXYLESTERASE
YBFK
(Bacillus
subtilis) 		5 / 6 GLY B  63
SER B 130
LEU B  65
ILE B 186
HIS B 274
 None
 1.37A 1yajF-4ccyB:
7.2		 1yajF-4ccyB:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 4ccy CARBOXYLESTERASE
YBFK
(Bacillus
subtilis) 		4 / 4 GLY B  63
SER B 130
ILE B 186
HIS B 274
 None
 0.84A 1yajJ-4ccyB:
5.7		 1yajJ-4ccyB:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 4ccy CARBOXYLESTERASE
YBFK
(Bacillus
subtilis) 		4 / 4 GLY B  64
SER B 130
ILE B 186
HIS B 274
 None
 1.09A 1yajJ-4ccyB:
5.7		 1yajJ-4ccyB:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4ccy CARBOXYLESTERASE
YBFK
(Bacillus
subtilis) 		5 / 11 TYR B  22
SER B  25
ILE B  75
HIS B  62
TRP B  71
 None
 1.16A 2a58A-4ccyB:
2.3
2a58E-4ccyB:
undetectable		 2a58A-4ccyB:
20.89
2a58E-4ccyB:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4ccy CARBOXYLESTERASE
YBFK
(Bacillus
subtilis) 		5 / 12 ILE B  75
HIS B  62
TRP B  71
TYR B  22
SER B  25
 None
 1.17A 2a58B-4ccyB:
2.1
2a58C-4ccyB:
undetectable		 2a58B-4ccyB:
20.89
2a58C-4ccyB:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4ccy CARBOXYLESTERASE
YBFK
(Bacillus
subtilis) 		5 / 11 ILE B  75
HIS B  62
TRP B  71
TYR B  22
SER B  25
 None
 1.16A 2a58C-4ccyB:
undetectable
2a58D-4ccyB:
2.1		 2a58C-4ccyB:
20.89
2a58D-4ccyB:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 4ccy CARBOXYLESTERASE
YBFK
(Bacillus
subtilis) 		5 / 11 VAL B  38
GLU B  34
ALA B  35
ALA B  86
ASP B  23
 None
 1.11A 2admB-4ccyB:
2.0		 2admB-4ccyB:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4ccy CARBOXYLESTERASE
YBFK
(Bacillus
subtilis) 		4 / 5 LEU B  61
ALA B 127
TRP B  78
LEU B  58
 None
 0.99A 2oaxA-4ccyB:
undetectable		 2oaxA-4ccyB:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 4ccy CARBOXYLESTERASE
YBFK
(Bacillus
subtilis) 		5 / 12 VAL B 261
LEU B 140
ILE B 160
VAL B 237
ILE B 136
 None
 0.86A 3frqB-4ccyB:
undetectable		 3frqB-4ccyB:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 4ccy CARBOXYLESTERASE
YBFK
(Bacillus
subtilis) 		4 / 8 PHE B 108
SER B 134
LEU B 131
LEU B 214
 None
 1.02A 3i45A-4ccyB:
3.0		 3i45A-4ccyB:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 4ccy CARBOXYLESTERASE
YBFK
(Bacillus
subtilis) 		4 / 5 TYR B  22
GLN B 200
ILE B 183
PHE B  18
 None
 1.27A 3ls4L-4ccyB:
undetectable		 3ls4L-4ccyB:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 4ccy CARBOXYLESTERASE
YBFK
(Bacillus
subtilis) 		4 / 6 GLY B  63
GLY B  64
SER B 130
HIS B 274
 None
 0.77A 3o9mB-4ccyB:
13.2		 3o9mB-4ccyB:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 4ccy CARBOXYLESTERASE
YBFK
(Bacillus
subtilis) 		3 / 3 PHE B 162
SER B 134
SER B 130
 None
 0.88A 3ufgB-4ccyB:
undetectable		 3ufgB-4ccyB:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 4ccy CARBOXYLESTERASE
YBFK
(Bacillus
subtilis) 		4 / 5 ILE B  31
PRO B  30
HIS B 194
TYR B  22
 None
 1.27A 4s0vA-4ccyB:
2.6		 4s0vA-4ccyB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4ccy CARBOXYLESTERASE
YBFK
(Bacillus
subtilis) 		4 / 4 GLN B 228
THR B 226
LEU B 140
LEU B 141
 None
 1.32A 5m5kB-4ccyB:
4.8		 5m5kB-4ccyB:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 4ccy CARBOXYLESTERASE
YBFK
(Bacillus
subtilis) 		5 / 12 HIS B  62
GLY B 220
PHE B 162
GLY B  64
GLY B  63
 None
 1.17A 6brdB-4ccyB:
undetectable		 6brdB-4ccyB:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 4ccy CARBOXYLESTERASE
YBFK
(Bacillus
subtilis) 		3 / 3 SER B  50
SER B  33
ALA B  69
 None
 0.72A 6dwnC-4ccyB:
undetectable		 6dwnC-4ccyB:
14.19