SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ccz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		4 / 7 ILE A 196
GLY A 226
PRO A 148
ASN A 259
 None
 0.95A 1oniG-4cczA:
2.7
1oniI-4cczA:
0.9		 1oniG-4cczA:
13.56
1oniI-4cczA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 12 PHE A 557
SER A 578
LEU A 617
PHE A 371
VAL A 612
 None
THG  A1652 (-4.2A)
None
None
None
 1.22A 1q23B-4cczA:
undetectable		 1q23B-4cczA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 12 PHE A 557
SER A 578
LEU A 617
PHE A 371
VAL A 612
 None
THG  A1652 (-4.2A)
None
None
None
 1.31A 1q23C-4cczA:
undetectable		 1q23C-4cczA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 11 PHE A 557
SER A 578
LEU A 617
PHE A 371
VAL A 612
 None
THG  A1652 (-4.2A)
None
None
None
 1.23A 1q23F-4cczA:
undetectable		 1q23F-4cczA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 11 PHE A 557
SER A 578
LEU A 617
PHE A 371
VAL A 612
 None
THG  A1652 (-4.2A)
None
None
None
 1.22A 1q23I-4cczA:
undetectable		 1q23I-4cczA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 11 PHE A 557
SER A 578
LEU A 617
PHE A 371
VAL A 612
 None
THG  A1652 (-4.2A)
None
None
None
 1.14A 1q23J-4cczA:
undetectable		 1q23J-4cczA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 11 PHE A 557
SER A 578
LEU A 617
PHE A 371
VAL A 612
 None
THG  A1652 (-4.2A)
None
None
None
 1.36A 1q23L-4cczA:
undetectable		 1q23L-4cczA:
15.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		7 / 12 ARG A 377
ASP A 449
ASP A 537
GLY A 576
SER A 578
ARG A 591
ILE A 611
 THG  A1652 ( 4.8A)
THG  A1652 (-3.4A)
THG  A1652 (-3.4A)
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.0A)
THG  A1652 (-4.2A)
 1.36A 1q8jA-4cczA:
36.8		 1q8jA-4cczA:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 12 ASN A 379
ASP A 449
ASN A 470
ASP A 537
ARG A 585
 THG  A1652 (-4.6A)
THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
THG  A1652 (-3.3A)
 0.92A 1q8jA-4cczA:
36.8		 1q8jA-4cczA:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		9 / 12 GLU A 376
ASN A 379
ASP A 449
ASN A 470
ASP A 537
GLY A 576
SER A 578
ARG A 591
ILE A 611
 THG  A1652 (-3.5A)
THG  A1652 (-4.6A)
THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.0A)
THG  A1652 (-4.2A)
 0.61A 1q8jA-4cczA:
36.8		 1q8jA-4cczA:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		9 / 12 GLU A 376
ASN A 379
ASP A 449
ASN A 470
GLY A 576
SER A 578
ASN A 579
ARG A 591
ILE A 611
 THG  A1652 (-3.5A)
THG  A1652 (-4.6A)
THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.1A)
THG  A1652 (-3.0A)
THG  A1652 (-4.2A)
 0.58A 1q8jB-4cczA:
37.0		 1q8jB-4cczA:
30.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 12 LEU A 191
LEU A 146
GLY A 182
ASP A 185
ASN A 118
 None
 1.29A 2bm9B-4cczA:
undetectable		 2bm9B-4cczA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 12 ASP A 414
GLY A 576
SER A 578
ASN A 579
ARG A 591
 None
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.1A)
THG  A1652 (-3.0A)
 0.99A 2e7fA-4cczA:
30.0		 2e7fA-4cczA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		8 / 12 GLU A 376
ASP A 449
ASN A 470
GLY A 576
SER A 578
ASN A 579
ARG A 591
ILE A 611
 THG  A1652 (-3.5A)
THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.1A)
THG  A1652 (-3.0A)
THG  A1652 (-4.2A)
 0.41A 2e7fA-4cczA:
30.0		 2e7fA-4cczA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		7 / 12 GLU A 376
ASN A 470
GLY A 576
SER A 578
ASN A 579
ARG A 591
ILE A 611
 THG  A1652 (-3.5A)
THG  A1652 (-3.2A)
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.1A)
THG  A1652 (-3.0A)
THG  A1652 (-4.2A)
 0.39A 2e7fB-4cczA:
30.1		 2e7fB-4cczA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		3 / 3 ASN A 539
ILE A 558
MET A 607
 None
 0.74A 2h42C-4cczA:
undetectable		 2h42C-4cczA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		7 / 12 GLU A 376
ASP A 449
ASN A 470
GLY A 576
SER A 578
ARG A 591
ILE A 611
 THG  A1652 (-3.5A)
THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.0A)
THG  A1652 (-4.2A)
 0.38A 2ogyA-4cczA:
29.9		 2ogyA-4cczA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		7 / 12 GLU A 376
ASP A 449
ASN A 470
GLY A 576
SER A 578
ARG A 591
ILE A 611
 THG  A1652 (-3.5A)
THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.0A)
THG  A1652 (-4.2A)
 0.38A 2ogyB-4cczA:
30.1		 2ogyB-4cczA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A933_1
(ANDROGEN RECEPTOR)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 10 ILE A 590
ASN A 579
GLU A 376
ASN A 613
GLU A 592
 None
THG  A1652 (-3.1A)
THG  A1652 (-3.5A)
None
None
 1.48A 2piwA-4cczA:
undetectable		 2piwA-4cczA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 10 PHE A  98
ILE A 222
LEU A 236
THR A 227
GLY A 147
 None
 1.35A 2v0mA-4cczA:
undetectable		 2v0mA-4cczA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 12 ASP A 414
ASP A 537
GLY A 576
SER A 578
ASN A 579
 None
THG  A1652 (-3.4A)
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.1A)
 0.90A 2ycjA-4cczA:
30.6		 2ycjA-4cczA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 12 ASP A 449
ASN A 470
ASP A 537
GLY A 575
ILE A 611
 THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
None
THG  A1652 (-4.2A)
 1.14A 2ycjA-4cczA:
30.6		 2ycjA-4cczA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		7 / 12 ASP A 449
ASN A 470
ASP A 537
GLY A 576
SER A 578
ASN A 579
ILE A 611
 THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.1A)
THG  A1652 (-4.2A)
 0.34A 2ycjA-4cczA:
30.6		 2ycjA-4cczA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 10 ASP A 537
ILE A 611
GLY A 610
PRO A 445
ILE A 468
 THG  A1652 (-3.4A)
THG  A1652 (-4.2A)
None
None
None
 1.09A 3em4V-4cczA:
undetectable		 3em4V-4cczA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		4 / 8 VAL A 612
VAL A 412
ILE A 603
GLY A 610
 None
 0.68A 3hjoA-4cczA:
undetectable		 3hjoA-4cczA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		4 / 8 VAL A 612
VAL A 412
ILE A 603
GLY A 610
 None
 0.68A 3hjoB-4cczA:
undetectable		 3hjoB-4cczA:
16.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		8 / 12 ASN A 379
GLY A 382
ASP A 414
VAL A 496
GLY A 576
ASN A 579
PHE A 582
ARG A 585
 THG  A1652 (-4.6A)
THG  A1652 (-3.8A)
None
None
THG  A1652 (-3.6A)
THG  A1652 (-3.1A)
THG  A1652 (-4.5A)
THG  A1652 (-3.3A)
 1.45A 3k13A-4cczA:
43.4		 3k13A-4cczA:
30.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 12 ASN A 379
GLY A 382
ASP A 449
GLY A 375
ARG A 591
 THG  A1652 (-4.6A)
THG  A1652 (-3.8A)
THG  A1652 (-3.4A)
None
THG  A1652 (-3.0A)
 1.26A 3k13A-4cczA:
43.4		 3k13A-4cczA:
30.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		11 / 12 GLU A 376
ASN A 379
GLY A 382
ASP A 449
VAL A 496
GLY A 576
SER A 578
ASN A 579
PHE A 582
ARG A 585
ILE A 611
 THG  A1652 (-3.5A)
THG  A1652 (-4.6A)
THG  A1652 (-3.8A)
THG  A1652 (-3.4A)
None
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.1A)
THG  A1652 (-4.5A)
THG  A1652 (-3.3A)
THG  A1652 (-4.2A)
 0.38A 3k13A-4cczA:
43.4		 3k13A-4cczA:
30.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		3 / 3 ASN A 470
ASP A 537
ARG A 585
 THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
THG  A1652 (-3.3A)
 0.64A 3k13A-4cczA:
43.4		 3k13A-4cczA:
30.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		3 / 3 ASN A 470
ASP A 537
ARG A 591
 THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
THG  A1652 (-3.0A)
 0.19A 3k13A-4cczA:
43.4		 3k13A-4cczA:
30.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		7 / 12 ASN A 379
GLY A 382
ASP A 414
VAL A 496
GLY A 576
SER A 578
ASN A 579
 THG  A1652 (-4.6A)
THG  A1652 (-3.8A)
None
None
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.1A)
 1.50A 3k13B-4cczA:
43.2		 3k13B-4cczA:
30.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		7 / 12 ASN A 379
GLY A 382
ASP A 449
ASN A 470
VAL A 496
ASN A 579
ARG A 585
 THG  A1652 (-4.6A)
THG  A1652 (-3.8A)
THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
None
THG  A1652 (-3.1A)
THG  A1652 (-3.3A)
 1.45A 3k13B-4cczA:
43.2		 3k13B-4cczA:
30.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 12 ASP A 449
ASN A 470
VAL A 496
GLY A 575
ILE A 611
 THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
None
None
THG  A1652 (-4.2A)
 1.11A 3k13B-4cczA:
43.2		 3k13B-4cczA:
30.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		11 / 12 GLU A 376
ASN A 379
GLY A 382
ASP A 449
ASN A 470
VAL A 496
GLY A 576
SER A 578
ASN A 579
ARG A 591
ILE A 611
 THG  A1652 (-3.5A)
THG  A1652 (-4.6A)
THG  A1652 (-3.8A)
THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
None
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.1A)
THG  A1652 (-3.0A)
THG  A1652 (-4.2A)
 0.30A 3k13B-4cczA:
43.2		 3k13B-4cczA:
30.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		10 / 12 GLU A 376
ASN A 379
GLY A 382
ASP A 449
VAL A 496
GLY A 576
SER A 578
ASN A 579
ARG A 591
ILE A 611
 THG  A1652 (-3.5A)
THG  A1652 (-4.6A)
THG  A1652 (-3.8A)
THG  A1652 (-3.4A)
None
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.1A)
THG  A1652 (-3.0A)
THG  A1652 (-4.2A)
 0.27A 3k13C-4cczA:
43.2		 3k13C-4cczA:
30.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		3 / 3 ASN A 470
ASP A 537
ARG A 585
 THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
THG  A1652 (-3.3A)
 0.81A 3k13C-4cczA:
43.2		 3k13C-4cczA:
30.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		4 / 7 LEU A 192
LEU A  33
ASN A 259
ASP A  34
 None
 0.83A 3lm8A-4cczA:
undetectable
3lm8C-4cczA:
undetectable		 3lm8A-4cczA:
17.67
3lm8C-4cczA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		4 / 8 ASP A  34
LEU A 192
LEU A  33
ASN A 259
 None
 0.99A 3lm8A-4cczA:
undetectable
3lm8C-4cczA:
undetectable		 3lm8A-4cczA:
17.67
3lm8C-4cczA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		4 / 8 ASP A  34
LEU A 192
LEU A  33
ASN A 259
 None
 0.91A 3lm8B-4cczA:
undetectable
3lm8D-4cczA:
undetectable		 3lm8B-4cczA:
17.67
3lm8D-4cczA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_A_CLMA221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 9 PHE A 557
SER A 578
LEU A 617
PHE A 371
VAL A 612
 None
THG  A1652 (-4.2A)
None
None
None
 1.40A 3u9fA-4cczA:
0.0		 3u9fA-4cczA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 10 PHE A 557
SER A 578
LEU A 617
PHE A 371
VAL A 612
 None
THG  A1652 (-4.2A)
None
None
None
 1.36A 3u9fE-4cczA:
undetectable		 3u9fE-4cczA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 12 PHE A 557
SER A 578
LEU A 617
PHE A 371
VAL A 612
 None
THG  A1652 (-4.2A)
None
None
None
 1.31A 3u9fJ-4cczA:
undetectable
3u9fK-4cczA:
undetectable		 3u9fJ-4cczA:
15.66
3u9fK-4cczA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 10 PHE A 557
SER A 578
LEU A 617
PHE A 371
VAL A 612
 None
THG  A1652 (-4.2A)
None
None
None
 1.35A 3u9fK-4cczA:
undetectable		 3u9fK-4cczA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 10 PHE A 557
SER A 578
LEU A 617
PHE A 371
VAL A 612
 None
THG  A1652 (-4.2A)
None
None
None
 1.32A 3u9fR-4cczA:
undetectable		 3u9fR-4cczA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		8 / 12 GLU A 376
ASN A 379
ASP A 449
ASP A 537
GLY A 576
SER A 578
ARG A 591
ILE A 611
 THG  A1652 (-3.5A)
THG  A1652 (-4.6A)
THG  A1652 (-3.4A)
THG  A1652 (-3.4A)
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.0A)
THG  A1652 (-4.2A)
 0.77A 4djeA-4cczA:
29.6		 4djeA-4cczA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		6 / 12 ASP A 414
ASP A 449
ASN A 470
ASP A 537
ASN A 579
ARG A 585
 None
THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
THG  A1652 (-3.1A)
THG  A1652 (-3.3A)
 1.17A 4djeB-4cczA:
29.3		 4djeB-4cczA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		9 / 12 GLU A 376
ASP A 414
ASP A 449
ASN A 470
ASP A 537
GLY A 576
SER A 578
ASN A 579
ARG A 591
 THG  A1652 (-3.5A)
None
THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.1A)
THG  A1652 (-3.0A)
 0.59A 4djeB-4cczA:
29.3		 4djeB-4cczA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 12 ASN A 379
ASP A 537
ASN A 579
ARG A 585
ILE A 611
 THG  A1652 (-4.6A)
THG  A1652 (-3.4A)
THG  A1652 (-3.1A)
THG  A1652 (-3.3A)
THG  A1652 (-4.2A)
 1.36A 4djfA-4cczA:
29.7		 4djfA-4cczA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 12 ASN A 416
ASP A 537
GLY A 576
ASN A 579
ILE A 611
 None
THG  A1652 (-3.4A)
THG  A1652 (-3.6A)
THG  A1652 (-3.1A)
THG  A1652 (-4.2A)
 1.11A 4djfA-4cczA:
29.7		 4djfA-4cczA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		8 / 12 GLU A 376
ASN A 379
ASP A 537
GLY A 576
SER A 578
ASN A 579
ARG A 591
ILE A 611
 THG  A1652 (-3.5A)
THG  A1652 (-4.6A)
THG  A1652 (-3.4A)
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.1A)
THG  A1652 (-3.0A)
THG  A1652 (-4.2A)
 0.48A 4djfA-4cczA:
29.7		 4djfA-4cczA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		7 / 12 GLU A 376
ASP A 414
ASP A 449
ASN A 470
GLY A 576
SER A 578
ARG A 591
 THG  A1652 (-3.5A)
None
THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.0A)
 0.56A 4djfB-4cczA:
29.6		 4djfB-4cczA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		7 / 12 GLU A 376
ASN A 379
ASP A 449
ASP A 537
GLY A 576
ILE A 611
ASN A 616
 THG  A1652 (-3.5A)
THG  A1652 (-4.6A)
THG  A1652 (-3.4A)
THG  A1652 (-3.4A)
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
None
 1.08A 4o1eA-4cczA:
28.3		 4o1eA-4cczA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		6 / 12 GLU A 376
ASN A 379
ASP A 449
GLY A 576
ILE A 611
ASN A 616
 THG  A1652 (-3.5A)
THG  A1652 (-4.6A)
THG  A1652 (-3.4A)
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
None
 1.11A 4o1eB-4cczA:
27.6		 4o1eB-4cczA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 12 ALA A 125
GLY A 123
LEU A 183
GLY A 187
VAL A 188
 None
 0.82A 4o33A-4cczA:
undetectable		 4o33A-4cczA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 12 ALA A 125
GLY A 123
LEU A 183
GLY A 187
VAL A 188
 None
 0.92A 4o3fA-4cczA:
undetectable		 4o3fA-4cczA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		4 / 7 GLY A 123
ALA A 122
THR A  95
SER A 100
 None
 0.86A 4r1zB-4cczA:
undetectable		 4r1zB-4cczA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		4 / 8 GLY A 321
GLU A 194
GLU A  94
ALA A 143
 None
 0.86A 4rjdA-4cczA:
undetectable
4rjdB-4cczA:
undetectable		 4rjdA-4cczA:
8.50
4rjdB-4cczA:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		3 / 3 ALA A 208
ASN A 211
LEU A 212
 None
 0.39A 5i1nB-4cczA:
undetectable		 5i1nB-4cczA:
5.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		3 / 3 ALA A 208
ASN A 211
LEU A 212
 None
 0.45A 5i1oA-4cczA:
undetectable		 5i1oA-4cczA:
5.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		9 / 12 GLU A 376
GLY A 382
ASP A 414
VAL A 496
GLY A 576
SER A 578
PHE A 582
ARG A 591
ILE A 611
 THG  A1652 (-3.5A)
THG  A1652 (-3.8A)
None
None
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-4.5A)
THG  A1652 (-3.0A)
THG  A1652 (-4.2A)
 0.63A 5vooA-4cczA:
38.6		 5vooA-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 5 ASN A 379
ASP A 449
ASN A 470
ASP A 537
ASN A 579
 THG  A1652 (-4.6A)
THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
THG  A1652 (-3.1A)
 0.23A 5vooA-4cczA:
38.6		 5vooA-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		6 / 12 ASN A 379
GLY A 382
ASP A 449
VAL A 496
GLY A 576
PHE A 582
 THG  A1652 (-4.6A)
THG  A1652 (-3.8A)
THG  A1652 (-3.4A)
None
THG  A1652 (-3.6A)
THG  A1652 (-4.5A)
 1.42A 5vooB-4cczA:
38.4		 5vooB-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		9 / 12 GLU A 376
ASN A 379
GLY A 382
ASP A 414
VAL A 496
GLY A 576
SER A 578
PHE A 582
ILE A 611
 THG  A1652 (-3.5A)
THG  A1652 (-4.6A)
THG  A1652 (-3.8A)
None
None
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-4.5A)
THG  A1652 (-4.2A)
 0.54A 5vooB-4cczA:
38.4		 5vooB-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		4 / 5 ASP A 414
ASP A 537
ASN A 579
ARG A 591
 None
THG  A1652 (-3.4A)
THG  A1652 (-3.1A)
THG  A1652 (-3.0A)
 0.88A 5vooB-4cczA:
38.4		 5vooB-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 5 ASP A 449
ASN A 470
ASP A 537
ASN A 579
ARG A 585
 THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
THG  A1652 (-3.1A)
THG  A1652 (-3.3A)
 1.22A 5vooB-4cczA:
38.4		 5vooB-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 5 ASP A 449
ASN A 470
ASP A 537
ASN A 579
ARG A 591
 THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
THG  A1652 (-3.1A)
THG  A1652 (-3.0A)
 0.33A 5vooB-4cczA:
38.4		 5vooB-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		9 / 12 GLU A 376
GLY A 382
ASP A 414
VAL A 496
GLY A 576
SER A 578
PHE A 582
ARG A 591
ILE A 611
 THG  A1652 (-3.5A)
THG  A1652 (-3.8A)
None
None
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-4.5A)
THG  A1652 (-3.0A)
THG  A1652 (-4.2A)
 0.60A 5vooC-4cczA:
38.7		 5vooC-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		4 / 5 ASN A 379
ASP A 414
ASP A 537
ASN A 579
 THG  A1652 (-4.6A)
None
THG  A1652 (-3.4A)
THG  A1652 (-3.1A)
 1.49A 5vooC-4cczA:
38.7		 5vooC-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 5 ASN A 379
ASP A 449
ASN A 470
ASP A 537
ASN A 579
 THG  A1652 (-4.6A)
THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
THG  A1652 (-3.1A)
 0.22A 5vooC-4cczA:
38.7		 5vooC-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		8 / 12 GLU A 376
ASN A 379
GLY A 382
ASP A 414
VAL A 496
GLY A 576
SER A 578
ILE A 611
 THG  A1652 (-3.5A)
THG  A1652 (-4.6A)
THG  A1652 (-3.8A)
None
None
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-4.2A)
 0.43A 5vooD-4cczA:
38.6		 5vooD-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		4 / 5 ASP A 414
ASP A 537
ASN A 579
ARG A 591
 None
THG  A1652 (-3.4A)
THG  A1652 (-3.1A)
THG  A1652 (-3.0A)
 0.88A 5vooD-4cczA:
38.6		 5vooD-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 5 ASP A 449
ASN A 470
ASP A 537
ASN A 579
ARG A 585
 THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
THG  A1652 (-3.1A)
THG  A1652 (-3.3A)
 1.20A 5vooD-4cczA:
38.6		 5vooD-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 5 ASP A 449
ASN A 470
ASP A 537
ASN A 579
ARG A 591
 THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
THG  A1652 (-3.1A)
THG  A1652 (-3.0A)
 0.34A 5vooD-4cczA:
38.6		 5vooD-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		8 / 12 GLU A 376
GLY A 382
ASP A 414
VAL A 496
GLY A 576
SER A 578
ARG A 591
ILE A 611
 THG  A1652 (-3.5A)
THG  A1652 (-3.8A)
None
None
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.0A)
THG  A1652 (-4.2A)
 0.48A 5vooE-4cczA:
38.6		 5vooE-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		4 / 5 ASN A 379
ASP A 414
ASP A 537
ASN A 579
 THG  A1652 (-4.6A)
None
THG  A1652 (-3.4A)
THG  A1652 (-3.1A)
 1.43A 5vooE-4cczA:
38.6		 5vooE-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 5 ASN A 379
ASP A 449
ASN A 470
ASP A 537
ASN A 579
 THG  A1652 (-4.6A)
THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
THG  A1652 (-3.1A)
 0.25A 5vooE-4cczA:
38.6		 5vooE-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		6 / 12 GLU A 376
ASN A 379
GLY A 382
ASP A 414
PHE A 582
ARG A 591
 THG  A1652 (-3.5A)
THG  A1652 (-4.6A)
THG  A1652 (-3.8A)
None
THG  A1652 (-4.5A)
THG  A1652 (-3.0A)
 0.76A 5vooF-4cczA:
38.6		 5vooF-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		9 / 12 GLU A 376
ASN A 379
GLY A 382
ASP A 414
VAL A 496
GLY A 576
SER A 578
ARG A 591
ILE A 611
 THG  A1652 (-3.5A)
THG  A1652 (-4.6A)
THG  A1652 (-3.8A)
None
None
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.0A)
THG  A1652 (-4.2A)
 0.44A 5vooF-4cczA:
38.6		 5vooF-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		4 / 4 ASP A 449
ASN A 470
ASP A 537
ASN A 579
 THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
THG  A1652 (-3.1A)
 0.23A 5vooF-4cczA:
38.6		 5vooF-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		6 / 12 ASN A 379
GLY A 382
ASP A 449
VAL A 496
GLY A 576
ASN A 579
 THG  A1652 (-4.6A)
THG  A1652 (-3.8A)
THG  A1652 (-3.4A)
None
THG  A1652 (-3.6A)
THG  A1652 (-3.1A)
 1.32A 5vopA-4cczA:
38.9		 5vopA-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		10 / 12 GLU A 376
ASN A 379
GLY A 382
ASP A 414
VAL A 496
GLY A 576
SER A 578
ASN A 579
ARG A 591
ILE A 611
 THG  A1652 (-3.5A)
THG  A1652 (-4.6A)
THG  A1652 (-3.8A)
None
None
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.1A)
THG  A1652 (-3.0A)
THG  A1652 (-4.2A)
 0.48A 5vopA-4cczA:
38.9		 5vopA-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		3 / 3 ASP A 449
ASN A 470
ASP A 537
 THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
 0.20A 5vopA-4cczA:
38.9		 5vopA-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		6 / 12 ASN A 379
GLY A 382
ASP A 449
VAL A 496
GLY A 576
ASN A 579
 THG  A1652 (-4.6A)
THG  A1652 (-3.8A)
THG  A1652 (-3.4A)
None
THG  A1652 (-3.6A)
THG  A1652 (-3.1A)
 1.36A 5vopB-4cczA:
38.6		 5vopB-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		5 / 12 ASN A 416
ASP A 414
VAL A 496
GLY A 576
ILE A 611
 None
None
None
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
 1.14A 5vopB-4cczA:
38.6		 5vopB-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		10 / 12 GLU A 376
ASN A 379
GLY A 382
ASP A 414
VAL A 496
GLY A 576
SER A 578
ASN A 579
ARG A 591
ILE A 611
 THG  A1652 (-3.5A)
THG  A1652 (-4.6A)
THG  A1652 (-3.8A)
None
None
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.1A)
THG  A1652 (-3.0A)
THG  A1652 (-4.2A)
 0.42A 5vopB-4cczA:
38.6		 5vopB-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		3 / 3 ASP A 449
ASN A 470
ASP A 537
 THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
 0.15A 5vopB-4cczA:
38.6		 5vopB-4cczA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 4ccz METHIONINE SYNTHASE
(Homo
sapiens) 		3 / 3 PHE A 481
ASP A 480
LYS A 484
 None
 0.72A 6awtD-4cczA:
undetectable		 6awtD-4cczA:
13.55