SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cd8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4cd8 ENDO-BETA-1,4-MANNAN
ASE
(Alicyclobacillus
acidocaldarius) 		4 / 8 PHE A 229
GLY A 233
VAL A 310
MET A 265
 None
 1.19A 1gsfA-4cd8A:
undetectable		 1gsfA-4cd8A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4cd8 ENDO-BETA-1,4-MANNAN
ASE
(Alicyclobacillus
acidocaldarius) 		4 / 8 PHE A 229
GLY A 233
VAL A 310
MET A 265
 None
 1.19A 1gsfB-4cd8A:
undetectable		 1gsfB-4cd8A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4cd8 ENDO-BETA-1,4-MANNAN
ASE
(Alicyclobacillus
acidocaldarius) 		4 / 8 PHE A 229
GLY A 233
VAL A 310
MET A 265
 None
 1.19A 1gsfD-4cd8A:
undetectable		 1gsfD-4cd8A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4cd8 ENDO-BETA-1,4-MANNAN
ASE
(Alicyclobacillus
acidocaldarius) 		4 / 6 ASP A 196
LEU A 176
GLY A 175
ARG A 170
 None
 0.75A 1mt1G-4cd8A:
undetectable
1mt1J-4cd8A:
undetectable		 1mt1G-4cd8A:
9.06
1mt1J-4cd8A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4cd8 ENDO-BETA-1,4-MANNAN
ASE
(Alicyclobacillus
acidocaldarius) 		4 / 7 ARG A 170
ASP A 196
LEU A 176
GLY A 175
 None
 0.79A 1mt1H-4cd8A:
undetectable
1mt1K-4cd8A:
undetectable		 1mt1H-4cd8A:
17.43
1mt1K-4cd8A:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4cd8 ENDO-BETA-1,4-MANNAN
ASE
(Alicyclobacillus
acidocaldarius) 		4 / 7 ARG A 170
ASP A 196
LEU A 176
GLY A 175
 None
 0.79A 1n13D-4cd8A:
undetectable
1n13E-4cd8A:
undetectable		 1n13D-4cd8A:
17.43
1n13E-4cd8A:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4cd8 ENDO-BETA-1,4-MANNAN
ASE
(Alicyclobacillus
acidocaldarius) 		4 / 8 ASP A 196
LEU A 176
GLY A 175
ARG A 170
 None
 0.76A 1n13A-4cd8A:
undetectable
1n13F-4cd8A:
undetectable		 1n13A-4cd8A:
9.06
1n13F-4cd8A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4cd8 ENDO-BETA-1,4-MANNAN
ASE
(Alicyclobacillus
acidocaldarius) 		4 / 6 ARG A 170
ASP A 196
LEU A 176
GLY A 175
 None
 0.79A 1n13H-4cd8A:
undetectable
1n13K-4cd8A:
undetectable		 1n13H-4cd8A:
17.43
1n13K-4cd8A:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4cd8 ENDO-BETA-1,4-MANNAN
ASE
(Alicyclobacillus
acidocaldarius) 		4 / 7 ASP A 196
LEU A 176
GLY A 175
ARG A 170
 None
 0.77A 1n13G-4cd8A:
undetectable
1n13J-4cd8A:
undetectable		 1n13G-4cd8A:
9.06
1n13J-4cd8A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4cd8 ENDO-BETA-1,4-MANNAN
ASE
(Alicyclobacillus
acidocaldarius) 		5 / 11 TYR A 262
VAL A 310
ALA A 311
PHE A 314
GLN A  42
 None
 0.80A 1uduA-4cd8A:
undetectable		 1uduA-4cd8A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4cd8 ENDO-BETA-1,4-MANNAN
ASE
(Alicyclobacillus
acidocaldarius) 		5 / 12 TYR A 262
VAL A 310
ALA A 311
PHE A 314
GLN A  42
 None
 0.78A 1uduB-4cd8A:
undetectable		 1uduB-4cd8A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA202_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4cd8 ENDO-BETA-1,4-MANNAN
ASE
(Alicyclobacillus
acidocaldarius) 		5 / 9 LEU A  39
GLN A  42
SER A 298
GLU A 307
ALA A  38
 None
 1.44A 1wrlA-4cd8A:
undetectable
1wrlB-4cd8A:
undetectable		 1wrlA-4cd8A:
14.53
1wrlB-4cd8A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4cd8 ENDO-BETA-1,4-MANNAN
ASE
(Alicyclobacillus
acidocaldarius) 		4 / 7 ARG A 170
ASP A 196
LEU A 176
GLY A 175
 None
 0.78A 2qqcD-4cd8A:
undetectable
2qqcE-4cd8A:
undetectable		 2qqcD-4cd8A:
17.28
2qqcE-4cd8A:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4cd8 ENDO-BETA-1,4-MANNAN
ASE
(Alicyclobacillus
acidocaldarius) 		4 / 8 ARG A 170
ASP A 196
LEU A 176
GLY A 175
 None
 0.80A 2qqcH-4cd8A:
undetectable
2qqcK-4cd8A:
undetectable		 2qqcH-4cd8A:
17.28
2qqcK-4cd8A:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4cd8 ENDO-BETA-1,4-MANNAN
ASE
(Alicyclobacillus
acidocaldarius) 		4 / 8 ARG A 170
ASP A 196
LEU A 176
GLY A 175
 None
 0.75A 2qqdB-4cd8A:
undetectable
2qqdC-4cd8A:
undetectable		 2qqdB-4cd8A:
17.61
2qqdC-4cd8A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4cd8 ENDO-BETA-1,4-MANNAN
ASE
(Alicyclobacillus
acidocaldarius) 		3 / 3 TYR A 203
GLU A 151
ASN A  97
 MVL  A 400 (-3.8A)
MVL  A 400 (-2.6A)
BMA  A 401 (-3.2A)
 0.95A 2y7hC-4cd8A:
undetectable		 2y7hC-4cd8A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 4cd8 ENDO-BETA-1,4-MANNAN
ASE
(Alicyclobacillus
acidocaldarius) 		4 / 6 ARG A 237
ASP A 296
LEU A 287
GLU A 282
 None
None
None
BMA  A 401 (-2.7A)
 1.06A 2ya7A-4cd8A:
undetectable		 2ya7A-4cd8A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 4cd8 ENDO-BETA-1,4-MANNAN
ASE
(Alicyclobacillus
acidocaldarius) 		3 / 3 GLU A  75
ASP A  73
TYR A 134
 None
 0.68A 2yvlB-4cd8A:
undetectable		 2yvlB-4cd8A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 4cd8 ENDO-BETA-1,4-MANNAN
ASE
(Alicyclobacillus
acidocaldarius) 		4 / 6 PHE A 275
PHE A 229
TYR A 278
VAL A 213
 None
 1.32A 3lb3A-4cd8A:
undetectable		 3lb3A-4cd8A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)		 4cd8 ENDO-BETA-1,4-MANNAN
ASE
(Alicyclobacillus
acidocaldarius) 		4 / 6 PHE A 275
PHE A 229
TYR A 278
VAL A 213
 None
 1.32A 3lb3B-4cd8A:
undetectable		 3lb3B-4cd8A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 4cd8 ENDO-BETA-1,4-MANNAN
ASE
(Alicyclobacillus
acidocaldarius) 		4 / 6 GLU A 231
ARG A 104
GLU A 151
SER A 201
 MVL  A 400 (-2.8A)
MVL  A 400 (-2.9A)
MVL  A 400 (-2.6A)
MVL  A 400 ( 4.5A)
 1.18A 4kr3A-4cd8A:
undetectable		 4kr3A-4cd8A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 4cd8 ENDO-BETA-1,4-MANNAN
ASE
(Alicyclobacillus
acidocaldarius) 		4 / 8 GLU A 106
PRO A  58
GLY A 101
ASP A 100
 None
 1.10A 5kgpA-4cd8A:
undetectable		 5kgpA-4cd8A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 4cd8 ENDO-BETA-1,4-MANNAN
ASE
(Alicyclobacillus
acidocaldarius) 		4 / 8 GLU A 106
PRO A  58
GLY A 101
ASP A 100
 None
 1.08A 5kgpB-4cd8A:
undetectable		 5kgpB-4cd8A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 4cd8 ENDO-BETA-1,4-MANNAN
ASE
(Alicyclobacillus
acidocaldarius) 		4 / 6 ARG A 104
GLY A 149
GLU A 151
SER A 201
 MVL  A 400 (-2.9A)
None
MVL  A 400 (-2.6A)
MVL  A 400 ( 4.5A)
 1.00A 5ny7A-4cd8A:
4.0		 5ny7A-4cd8A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 4cd8 ENDO-BETA-1,4-MANNAN
ASE
(Alicyclobacillus
acidocaldarius) 		3 / 3 SER A 236
SER A 298
ALA A 292
 None
 0.68A 6dwnC-4cd8A:
undetectable		 6dwnC-4cd8A:
13.40