SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cdb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4cdb LISTERIOLYSIN O
(Listeria
monocytogenes) 		4 / 6 ASN A 179
ARG A 149
ILE A 293
GLY A 128
 NA  A1535 (-2.7A)
NA  A1538 ( 4.3A)
None
None
 1.09A 1oniA-4cdbA:
undetectable
1oniB-4cdbA:
undetectable		 1oniA-4cdbA:
15.70
1oniB-4cdbA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4cdb LISTERIOLYSIN O
(Listeria
monocytogenes) 		4 / 6 ASN A 179
ARG A 149
ILE A 293
GLY A 128
 NA  A1535 (-2.7A)
NA  A1538 ( 4.3A)
None
None
 1.12A 1oniD-4cdbA:
undetectable
1oniF-4cdbA:
undetectable		 1oniD-4cdbA:
15.70
1oniF-4cdbA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4cdb LISTERIOLYSIN O
(Listeria
monocytogenes) 		5 / 12 PHE A 464
ILE A 477
SER A 454
ASN A 456
ILE A 468
 None
 1.10A 2e7fA-4cdbA:
undetectable		 2e7fA-4cdbA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4cdb LISTERIOLYSIN O
(Listeria
monocytogenes) 		5 / 12 PHE A 464
ILE A 477
SER A 454
ASN A 456
ILE A 468
 None
 1.08A 2e7fB-4cdbA:
undetectable		 2e7fB-4cdbA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 4cdb LISTERIOLYSIN O
(Listeria
monocytogenes) 		4 / 7 GLU A 443
PRO A  87
LYS A  90
GLY A 444
 None
 1.31A 2hs1B-4cdbA:
undetectable		 2hs1B-4cdbA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4cdb LISTERIOLYSIN O
(Listeria
monocytogenes) 		5 / 12 PHE A 464
ILE A 477
SER A 454
ASN A 456
ILE A 468
 None
 1.06A 2ycjA-4cdbA:
undetectable		 2ycjA-4cdbA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4cdb LISTERIOLYSIN O
(Listeria
monocytogenes) 		4 / 6 ILE A 249
ILE A 108
TYR A 406
LEU A 306
 None
NA  A1536 ( 4.4A)
NA  A1536 (-4.5A)
None
 1.10A 3adsA-4cdbA:
undetectable		 3adsA-4cdbA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4cdb LISTERIOLYSIN O
(Listeria
monocytogenes) 		5 / 12 VAL A 479
PHE A 464
ARG A 507
ILE A 421
SER A 466
 None
 1.14A 4c49D-4cdbA:
undetectable		 4c49D-4cdbA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4cdb LISTERIOLYSIN O
(Listeria
monocytogenes) 		5 / 12 PHE A 464
ILE A 477
SER A 454
ASN A 456
ILE A 468
 None
 1.06A 4djfA-4cdbA:
undetectable		 4djfA-4cdbA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4cdb LISTERIOLYSIN O
(Listeria
monocytogenes) 		5 / 12 VAL A 138
SER A 404
ASN A 402
GLY A 222
GLY A  80
 None
None
NA  A1533 (-3.1A)
NA  A1533 (-3.4A)
None
 1.21A 4pevB-4cdbA:
undetectable		 4pevB-4cdbA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 4cdb LISTERIOLYSIN O
(Listeria
monocytogenes) 		3 / 3 TYR A 387
ALA A 291
LEU A 137
 None
 0.73A 6d9kF-4cdbA:
2.0		 6d9kF-4cdbA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 4cdb LISTERIOLYSIN O
(Listeria
monocytogenes) 		3 / 3 ASP A 320
ASP A 207
ASN A 402
 NA  A1542 (-3.8A)
NA  A1531 (-3.5A)
NA  A1533 (-3.1A)
 0.85A 6gngB-4cdbA:
undetectable		 6gngB-4cdbA:
21.28