SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cdo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 4cdo THIOREDOXIN-LIKE
PROTEIN 4A,
POLYGLUTAMINE-BINDIN
G PROTEIN
(Homo
sapiens) 		5 / 12 PHE A  83
ILE A 115
VAL A  27
ALA A  56
ILE A  58
 None
 0.97A 1epbA-4cdoA:
undetectable		 1epbA-4cdoA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 4cdo THIOREDOXIN-LIKE
PROTEIN 4A,
POLYGLUTAMINE-BINDIN
G PROTEIN
(Homo
sapiens) 		5 / 12 PHE A  83
ILE A 115
VAL A  27
ALA A  56
ILE A  58
 None
 1.01A 1epbB-4cdoA:
undetectable		 1epbB-4cdoA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4cdo THIOREDOXIN-LIKE
PROTEIN 4A,
POLYGLUTAMINE-BINDIN
G PROTEIN
(Homo
sapiens) 		5 / 12 VAL A  27
LEU A   5
LEU A  45
SER A  47
GLU A  50
 None
 1.48A 1mmkA-4cdoA:
undetectable		 1mmkA-4cdoA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 4cdo THIOREDOXIN-LIKE
PROTEIN 4A,
POLYGLUTAMINE-BINDIN
G PROTEIN
(Homo
sapiens) 		4 / 6 CYH A  79
THR A  80
CYH A  38
ASP A  35
 None
 1.18A 3w9tB-4cdoA:
undetectable		 3w9tB-4cdoA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 4cdo THIOREDOXIN-LIKE
PROTEIN 4A,
POLYGLUTAMINE-BINDIN
G PROTEIN
(Homo
sapiens) 		4 / 6 CYH A  79
THR A  80
CYH A  38
ASP A  35
 None
 1.17A 3w9tE-4cdoA:
undetectable		 3w9tE-4cdoA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 4cdo THIOREDOXIN-LIKE
PROTEIN 4A,
POLYGLUTAMINE-BINDIN
G PROTEIN
(Homo
sapiens) 		3 / 3 ASN A  87
SER A 247
ARG A 253
 None
 0.81A 5b2qA-4cdoA:
undetectable		 5b2qA-4cdoA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 4cdo THIOREDOXIN-LIKE
PROTEIN 4A,
POLYGLUTAMINE-BINDIN
G PROTEIN
(Homo
sapiens) 		3 / 3 TYR A  73
HIS A  89
PHE A  84
 None
 1.07A 6esmA-4cdoA:
undetectable		 6esmA-4cdoA:
19.54