SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cdp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4cdp PUTATIVE
HEME/HEMOGLOBIN
TRANSPORT PROTEIN
(Escherichia
coli) 		5 / 9 VAL A 242
LEU A 230
ILE A 311
ALA A  71
LEU A 276
 None
 1.17A 1eqgA-4cdpA:
undetectable		 1eqgA-4cdpA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4cdp PUTATIVE
HEME/HEMOGLOBIN
TRANSPORT PROTEIN
(Escherichia
coli) 		5 / 11 VAL A 242
LEU A 230
ILE A 311
ALA A  71
LEU A 276
 None
 1.16A 1eqgB-4cdpA:
undetectable		 1eqgB-4cdpA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1867_0
(FPRA)		 4cdp PUTATIVE
HEME/HEMOGLOBIN
TRANSPORT PROTEIN
(Escherichia
coli) 		4 / 4 ALA A 326
ARG A 329
GLN A 325
GLU A 324
 None
 1.30A 1lqtB-4cdpA:
undetectable		 1lqtB-4cdpA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1424_0
(FPRA)		 4cdp PUTATIVE
HEME/HEMOGLOBIN
TRANSPORT PROTEIN
(Escherichia
coli) 		4 / 4 ALA A 326
ARG A 329
GLN A 325
GLU A 324
 None
 1.28A 1lquB-4cdpA:
undetectable		 1lquB-4cdpA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)		 4cdp PUTATIVE
HEME/HEMOGLOBIN
TRANSPORT PROTEIN
(Escherichia
coli) 		3 / 3 THR A 190
THR A 293
PRO A 292
 None
HEM  A 402 ( 4.8A)
EDO  A1343 (-3.8A)
 0.86A 1qfiB-4cdpA:
undetectable		 1qfiB-4cdpA:
2.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_B_THAB401_1
(HISTAMINE
N-METHYLTRANSFERASE)		 4cdp PUTATIVE
HEME/HEMOGLOBIN
TRANSPORT PROTEIN
(Escherichia
coli) 		4 / 7 PHE A 304
PHE A 210
GLU A 302
GLN A 313
 None
None
HEM  A 402 ( 4.7A)
HEM  A 402 (-3.4A)
 1.49A 2aoxB-4cdpA:
undetectable		 2aoxB-4cdpA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4cdp PUTATIVE
HEME/HEMOGLOBIN
TRANSPORT PROTEIN
(Escherichia
coli) 		5 / 10 THR A 299
VAL A 288
SER A 232
ASN A 238
GLY A 316
 None
None
EDO  A1347 (-3.5A)
None
None
 1.47A 2x2iD-4cdpA:
undetectable		 2x2iD-4cdpA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 4cdp PUTATIVE
HEME/HEMOGLOBIN
TRANSPORT PROTEIN
(Escherichia
coli) 		3 / 3 TYR A 315
VAL A 192
THR A 299
 HEM  A 402 (-3.8A)
HEM  A 402 (-4.6A)
None
 0.65A 2ygnA-4cdpA:
undetectable		 2ygnA-4cdpA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4cdp PUTATIVE
HEME/HEMOGLOBIN
TRANSPORT PROTEIN
(Escherichia
coli) 		3 / 3 ALA A  71
ARG A  67
LYS A 136
 None
None
EDO  A1341 (-2.9A)
 1.07A 3kp5B-4cdpA:
undetectable		 3kp5B-4cdpA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 4cdp PUTATIVE
HEME/HEMOGLOBIN
TRANSPORT PROTEIN
(Escherichia
coli) 		3 / 3 ALA A 218
TRP A 287
VAL A 288
 EDO  A1346 (-4.6A)
None
None
 0.42A 4w9nC-4cdpA:
undetectable		 4w9nC-4cdpA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4cdp PUTATIVE
HEME/HEMOGLOBIN
TRANSPORT PROTEIN
(Escherichia
coli) 		5 / 11 LEU A 301
LEU A 314
LEU A 226
GLU A 231
LEU A 230
 None
 1.17A 4wg0J-4cdpA:
undetectable
4wg0K-4cdpA:
undetectable
4wg0L-4cdpA:
undetectable		 4wg0J-4cdpA:
5.24
4wg0K-4cdpA:
5.24
4wg0L-4cdpA:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4cdp PUTATIVE
HEME/HEMOGLOBIN
TRANSPORT PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 198
GLU A 183
VAL A 182
GLU A 302
TRP A 328
 EDO  A1338 (-4.3A)
None
None
HEM  A 402 ( 4.7A)
None
 1.32A 5xipD-4cdpA:
undetectable		 5xipD-4cdpA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4cdp PUTATIVE
HEME/HEMOGLOBIN
TRANSPORT PROTEIN
(Escherichia
coli) 		4 / 6 GLY A 237
ASN A 238
ASP A 236
SER A 232
 None
None
EDO  A1347 (-3.2A)
EDO  A1347 (-3.5A)
 1.14A 6dwdA-4cdpA:
undetectable
6dwdC-4cdpA:
undetectable		 6dwdA-4cdpA:
21.84
6dwdC-4cdpA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 4cdp PUTATIVE
HEME/HEMOGLOBIN
TRANSPORT PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 198
GLU A 183
VAL A 182
GLU A 302
TRP A 328
 EDO  A1338 (-4.3A)
None
None
HEM  A 402 ( 4.7A)
None
 1.21A 6mn8A-4cdpA:
undetectable		 6mn8A-4cdpA:
21.90