SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ce4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4ce4 MRPL38
(Sus
scrofa) 		5 / 11 VAL b 204
LEU b 216
TYR b 154
ALA b 317
LEU b 173
 None
 1.16A 1eqgB-4ce4b:
undetectable		 1eqgB-4ce4b:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 4ce4 MRPL15
(Sus
scrofa) 		5 / 11 LEU P 118
ALA P 166
ALA P 163
VAL P 138
LEU P  96
 None
 1.27A 1hbpA-4ce4P:
undetectable		 1hbpA-4ce4P:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 4ce4 MRPL4
(Sus
scrofa) 		3 / 3 THR F 197
GLU F 194
ASP F 191
 None
 0.85A 1nt2A-4ce4F:
undetectable		 1nt2A-4ce4F:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 4ce4 MRPL49
(Sus
scrofa) 		4 / 5 LEU l 147
VAL l 140
ARG l 148
THR l 146
 None
 1.50A 1nw3A-4ce4l:
undetectable		 1nw3A-4ce4l:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 4ce4 MRPL20
(Sus
scrofa) 		4 / 6 PHE U 113
ALA U 117
LEU U 116
SER U  76
 None
 1.04A 1sbrA-4ce4U:
undetectable
1sbrB-4ce4U:
undetectable		 1sbrA-4ce4U:
17.07
1sbrB-4ce4U:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ce4 MRPL44
(Sus
scrofa) 		5 / 12 ILE h 199
ALA h 201
GLN h 204
ASN h 122
LEU h 125
 None
 0.96A 2aclG-4ce4h:
undetectable		 2aclG-4ce4h:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 4ce4 MRPL15
(Sus
scrofa) 		3 / 3 ARG P  59
GLU P  56
GLN P  58
 U  A 353 ( 3.2A)
G  A 351 ( 3.1A)
U  A 356 ( 3.1A)
 1.05A 2p16A-4ce4P:
undetectable		 2p16A-4ce4P:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 4ce4 MRPL22
MRPL39
(Sus
scrofa;
Sus
scrofa) 		3 / 3 CYH c  88
HIS c  91
PHE W 134
 None
 1.23A 3cr4X-4ce4c:
undetectable		 3cr4X-4ce4c:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4ce4 MRPL4
MRPL15
MRPL49
(Sus
scrofa;
Sus
scrofa;
Sus
scrofa) 		5 / 12 SER P  33
GLU l 142
VAL F 176
ASP F  94
ILE F  95
 U  A 212 ( 2.7A)
A  A 213 ( 4.4A)
None
U  A 212 ( 3.7A)
None
 1.32A 3jayA-4ce4P:
undetectable		 3jayA-4ce4P:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 4ce4 MRPL38
(Sus
scrofa) 		3 / 3 SER b 263
ASP b 222
ASN b 220
 None
 0.82A 3lsfB-4ce4b:
undetectable
3lsfE-4ce4b:
undetectable		 3lsfB-4ce4b:
18.05
3lsfE-4ce4b:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		 4ce4 MRPL38
(Sus
scrofa) 		3 / 3 ASP b 222
ASN b 220
SER b 263
 None
 0.79A 3lsfB-4ce4b:
undetectable
3lsfE-4ce4b:
undetectable		 3lsfB-4ce4b:
18.05
3lsfE-4ce4b:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ce4 MRPL44
(Sus
scrofa) 		4 / 8 PHE h 196
GLU h 127
SER h 131
ARG h 192
 None
 1.18A 3nlrA-4ce4h:
undetectable
3nlrB-4ce4h:
undetectable		 3nlrA-4ce4h:
20.33
3nlrB-4ce4h:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ce4 MRPL44
(Sus
scrofa) 		4 / 8 PHE h 196
GLU h 127
SER h 131
ARG h 192
 None
 1.23A 3nlyA-4ce4h:
undetectable
3nlyB-4ce4h:
undetectable		 3nlyA-4ce4h:
20.33
3nlyB-4ce4h:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4ce4 MRPL18
(Sus
scrofa) 		5 / 12 GLU S 126
GLY S 129
ALA S 164
ALA S  92
VAL S 128
 None
 1.12A 3nvkF-4ce4S:
4.1
3nvkJ-4ce4S:
undetectable		 3nvkF-4ce4S:
19.61
3nvkJ-4ce4S:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 4ce4 MRPL38
(Sus
scrofa) 		6 / 12 VAL b 204
LEU b 271
LEU b 216
TYR b 154
ALA b 317
LEU b 173
 None
 1.32A 3pghC-4ce4b:
undetectable		 3pghC-4ce4b:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ce4 MRPL44
(Sus
scrofa) 		4 / 8 PHE h 196
GLU h 127
SER h 131
ARG h 192
 None
 1.21A 3rqlA-4ce4h:
undetectable
3rqlB-4ce4h:
undetectable		 3rqlA-4ce4h:
20.33
3rqlB-4ce4h:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ce4 MRPL38
(Sus
scrofa) 		5 / 12 VAL b 204
LEU b 216
TYR b 154
ALA b 317
LEU b 173
 None
 1.02A 3rr3A-4ce4b:
undetectable		 3rr3A-4ce4b:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ce4 MRPL38
(Sus
scrofa) 		5 / 12 VAL b 204
LEU b 216
TYR b 154
ALA b 317
LEU b 173
 None
 1.02A 3rr3B-4ce4b:
undetectable		 3rr3B-4ce4b:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 4ce4 MRPL17
(Sus
scrofa) 		3 / 3 ARG R  13
PRO R  22
PHE R  15
 C  A 993 ( 2.6A)
None
None
 1.02A 3thrC-4ce4R:
undetectable		 3thrC-4ce4R:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 4ce4 MRPL21
(Sus
scrofa) 		5 / 9 LEU V 139
LEU V  99
ILE V 199
ILE V 118
VAL V 103
 None
 1.32A 3tmzA-4ce4V:
undetectable		 3tmzA-4ce4V:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4ce4 MRPL15
MRPL4
(Sus
scrofa) 		4 / 5 LEU F  93
LEU F  96
LEU P  24
SER P  23
 None
None
U  A 611 ( 4.2A)
U  A 611 ( 4.0A)
 0.90A 3vhuA-4ce4F:
undetectable		 3vhuA-4ce4F:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ce4 MRPL44
(Sus
scrofa) 		4 / 8 PHE h 196
GLU h 127
SER h 131
ARG h 192
 None
 1.23A 4capA-4ce4h:
undetectable
4capB-4ce4h:
undetectable		 4capA-4ce4h:
20.33
4capB-4ce4h:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4ce4 MRPL44
(Sus
scrofa) 		4 / 8 SER h 131
ARG h 192
PHE h 196
GLU h 127
 None
 1.23A 4cx7C-4ce4h:
undetectable
4cx7D-4ce4h:
undetectable		 4cx7C-4ce4h:
21.44
4cx7D-4ce4h:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ce4 MRPL44
(Sus
scrofa) 		4 / 8 PHE h 196
GLU h 127
SER h 131
ARG h 192
 None
 1.19A 4d32A-4ce4h:
undetectable
4d32B-4ce4h:
undetectable		 4d32A-4ce4h:
20.33
4d32B-4ce4h:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 4ce4 MRPL15
(Sus
scrofa) 		3 / 3 VAL P 173
GLY P 171
LYS P 151
 None
 0.72A 4k50A-4ce4P:
undetectable		 4k50A-4ce4P:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 4ce4 MRPL15
(Sus
scrofa) 		3 / 3 VAL P 173
GLY P 171
LYS P 151
 None
 0.73A 4k50I-4ce4P:
undetectable		 4k50I-4ce4P:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_2
(ASPARTYL PROTEASE)		 4ce4 MRPL3
(Sus
scrofa) 		5 / 12 LEU E 173
ALA E 246
ILE E 327
VAL E 336
ILE E 334
 None
 0.91A 4q1xB-4ce4E:
undetectable		 4q1xB-4ce4E:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 4ce4 MRPL15
(Sus
scrofa) 		5 / 12 PHE P 148
ILE P 105
ALA P 150
VAL P 156
LEU P  98
 None
 1.14A 4qzuC-4ce4P:
undetectable		 4qzuC-4ce4P:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 4ce4 MRPL39
(Sus
scrofa) 		5 / 12 ARG c 153
GLY c 255
ALA c 144
MET c 145
GLY c 148
 None
 1.30A 4r29B-4ce4c:
undetectable		 4r29B-4ce4c:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ce4 MRPL44
(Sus
scrofa) 		4 / 8 PHE h 196
GLU h 127
SER h 131
ARG h 192
 None
 1.20A 4v3yA-4ce4h:
undetectable
4v3yB-4ce4h:
undetectable		 4v3yA-4ce4h:
20.33
4v3yB-4ce4h:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4ce4 MRPL4
(Sus
scrofa) 		5 / 10 GLY F 247
THR F 265
VAL F 243
LEU F 269
LEU F 217
 None
 1.00A 4yb6A-4ce4F:
undetectable
4yb6E-4ce4F:
undetectable		 4yb6A-4ce4F:
19.67
4yb6E-4ce4F:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4ce4 MRPL4
(Sus
scrofa) 		5 / 10 GLY F 247
THR F 265
VAL F 243
LEU F 269
LEU F 217
 None
 0.99A 4yb6B-4ce4F:
undetectable
4yb6C-4ce4F:
undetectable		 4yb6B-4ce4F:
19.67
4yb6C-4ce4F:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4ce4 MRPL4
(Sus
scrofa) 		5 / 10 GLY F 247
THR F 265
VAL F 243
LEU F 269
LEU F 217
 None
 1.01A 4yb6C-4ce4F:
undetectable
4yb6F-4ce4F:
undetectable		 4yb6C-4ce4F:
19.67
4yb6F-4ce4F:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4ce4 MRPL4
(Sus
scrofa) 		5 / 10 LEU F 269
LEU F 217
GLY F 247
THR F 265
VAL F 243
 None
 1.01A 4yb6A-4ce4F:
undetectable
4yb6D-4ce4F:
undetectable		 4yb6A-4ce4F:
19.67
4yb6D-4ce4F:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4ce4 MRPL4
(Sus
scrofa) 		5 / 10 LEU F 269
LEU F 217
GLY F 247
THR F 265
VAL F 243
 None
 0.99A 4yb6D-4ce4F:
undetectable
4yb6E-4ce4F:
undetectable		 4yb6D-4ce4F:
19.67
4yb6E-4ce4F:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4ce4 MRPL4
(Sus
scrofa) 		5 / 10 LEU F 269
LEU F 217
GLY F 247
THR F 265
VAL F 243
 None
 0.99A 4yb6B-4ce4F:
undetectable
4yb6F-4ce4F:
undetectable		 4yb6B-4ce4F:
19.67
4yb6F-4ce4F:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 4ce4 MRPL17
(Sus
scrofa) 		5 / 11 LEU R  36
GLU R  40
LEU R  89
LEU R  93
LEU R  80
 None
 1.34A 4zn7B-4ce4R:
undetectable		 4zn7B-4ce4R:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 4ce4 MRPL44
(Sus
scrofa) 		4 / 7 PHE h 196
GLU h 127
SER h 131
ARG h 192
 None
 1.18A 5adlA-4ce4h:
undetectable
5adlB-4ce4h:
undetectable		 5adlA-4ce4h:
19.13
5adlB-4ce4h:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		 4ce4 MRPL38
(Sus
scrofa) 		4 / 8 ASN b 191
PRO b 186
PHE b 319
TYR b 158
 None
 1.24A 5amkA-4ce4b:
undetectable		 5amkA-4ce4b:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4ce4 MRPL39
(Sus
scrofa) 		4 / 6 LYS c 156
ARG c 165
SER c 162
LEU c 163
 None
 1.12A 5bphA-4ce4c:
undetectable		 5bphA-4ce4c:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4ce4 MRPL18
(Sus
scrofa) 		4 / 6 VAL S 170
LEU S 172
CYH S 136
LEU S  81
 None
 1.12A 5hrqB-4ce4S:
undetectable
5hrqI-4ce4S:
undetectable
5hrqJ-4ce4S:
undetectable		 5hrqB-4ce4S:
17.65
5hrqI-4ce4S:
9.60
5hrqJ-4ce4S:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ce4 MRPL44
(Sus
scrofa) 		4 / 8 SER h 131
ARG h 192
PHE h 196
GLU h 127
 None
 1.18A 5uo7A-4ce4h:
undetectable
5uo7B-4ce4h:
undetectable		 5uo7A-4ce4h:
19.91
5uo7B-4ce4h:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 4ce4 MRPL22
MRPL39
(Sus
scrofa;
Sus
scrofa) 		3 / 3 HIS c  91
GLU W 133
ASN W 131
 None
 0.91A 5wbvA-4ce4c:
undetectable		 5wbvA-4ce4c:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 4ce4 MRPL22
MRPL39
(Sus
scrofa;
Sus
scrofa) 		3 / 3 HIS c  91
GLU W 133
ASN W 131
 None
 0.92A 5wbvB-4ce4c:
undetectable		 5wbvB-4ce4c:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ce4 MRPL44
(Sus
scrofa) 		4 / 7 PHE h 196
GLU h 127
SER h 131
ARG h 192
 None
 1.18A 6av6C-4ce4h:
undetectable
6av6D-4ce4h:
undetectable		 6av6C-4ce4h:
17.49
6av6D-4ce4h:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 4ce4 MRPL20
MRPL21
(Sus
scrofa) 		4 / 7 VAL V 137
PRO U 110
PHE U 113
PHE V 100
 None
 1.09A 6aycA-4ce4V:
undetectable		 6aycA-4ce4V:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_I_EY4I500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4ce4 MRPL3
(Sus
scrofa) 		4 / 5 GLN E 267
VAL E 269
TRP E 273
THR E 306
 None
None
None
U  A1440 ( 4.3A)
 1.47A 6cduI-4ce4E:
undetectable
6cduJ-4ce4E:
undetectable		 6cduI-4ce4E:
21.98
6cduJ-4ce4E:
21.98