SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ce5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GFZ_A_CFFA940_1
(GLYCOGEN
PHOSPHORYLASE)		 4ce5 AT-OMEGATA
(Aspergillus
terreus) 		4 / 6 PHE A   8
ALA A  12
GLY A  10
TYR A  11
 None
None
CL  A1330 ( 4.0A)
None
 1.09A 1gfzA-4ce5A:
undetectable		 1gfzA-4ce5A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4ce5 AT-OMEGATA
(Aspergillus
terreus) 		4 / 8 TYR A 146
PHE A 115
GLY A 277
VAL A 238
 None
None
None
PLP  A1180 ( 3.7A)
 1.01A 1gsfC-4ce5A:
undetectable		 1gsfC-4ce5A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4ce5 AT-OMEGATA
(Aspergillus
terreus) 		4 / 6 PHE A   8
ALA A  12
GLY A  10
TYR A  11
 None
None
CL  A1330 ( 4.0A)
None
 1.08A 1l7xA-4ce5A:
undetectable		 1l7xA-4ce5A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 4ce5 AT-OMEGATA
(Aspergillus
terreus) 		5 / 10 ALA A 194
GLU A 193
LEU A 204
MET A 272
ILE A 219
 None
 1.46A 1qkuA-4ce5A:
undetectable		 1qkuA-4ce5A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 4ce5 AT-OMEGATA
(Aspergillus
terreus) 		5 / 10 ALA A 194
GLU A 193
LEU A 204
MET A 272
ILE A 219
 None
 1.45A 1qkuB-4ce5A:
undetectable		 1qkuB-4ce5A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 4ce5 AT-OMEGATA
(Aspergillus
terreus) 		5 / 10 ALA A 194
GLU A 193
LEU A 204
MET A 272
ILE A 219
 None
 1.46A 1qkuC-4ce5A:
undetectable		 1qkuC-4ce5A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 4ce5 AT-OMEGATA
(Aspergillus
terreus) 		4 / 8 PRO A 202
LEU A 187
GLY A 185
LEU A 204
 None
 0.93A 1ya4A-4ce5A:
undetectable		 1ya4A-4ce5A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 4ce5 AT-OMEGATA
(Aspergillus
terreus) 		4 / 7 PRO A 202
LEU A 187
GLY A 185
LEU A 204
 None
 0.90A 1ya4B-4ce5A:
undetectable		 1ya4B-4ce5A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4ce5 AT-OMEGATA
(Aspergillus
terreus) 		3 / 3 ASP A  57
ASP A  50
ASN A 181
 None
None
CL  A1327 (-3.1A)
 0.81A 2bm9D-4ce5A:
undetectable		 2bm9D-4ce5A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4ce5 AT-OMEGATA
(Aspergillus
terreus) 		4 / 6 PHE A   8
ALA A  12
GLY A  10
TYR A  11
 None
None
CL  A1330 ( 4.0A)
None
 1.07A 3dd1B-4ce5A:
undetectable		 3dd1B-4ce5A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4ce5 AT-OMEGATA
(Aspergillus
terreus) 		4 / 5 PRO A  92
THR A 130
VAL A 127
GLY A 126
 None
 1.00A 3elzA-4ce5A:
undetectable		 3elzA-4ce5A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_D_ACTD229_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4ce5 AT-OMEGATA
(Aspergillus
terreus) 		4 / 4 ASP A 224
GLY A 225
LYS A 223
GLU A 269
 None
 1.35A 3hznD-4ce5A:
undetectable		 3hznD-4ce5A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 4ce5 AT-OMEGATA
(Aspergillus
terreus) 		3 / 3 ILE A 175
VAL A 170
ARG A 169
 CL  A1327 (-4.0A)
None
CL  A1327 (-3.0A)
 0.58A 3p73A-4ce5A:
undetectable		 3p73A-4ce5A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 4ce5 AT-OMEGATA
(Aspergillus
terreus) 		4 / 8 VAL A 222
VAL A 220
ILE A 279
ILE A 302
 None
 0.75A 3warA-4ce5A:
undetectable		 3warA-4ce5A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4ce5 AT-OMEGATA
(Aspergillus
terreus) 		3 / 3 ASP A 224
ARG A 266
LYS A 223
 None
 1.15A 3wipG-4ce5A:
undetectable		 3wipG-4ce5A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 4ce5 AT-OMEGATA
(Aspergillus
terreus) 		5 / 11 GLY A 123
ARG A 122
LEU A  58
GLY A  52
ALA A 276
 None
None
None
None
PDG  A1181 ( 3.7A)
 1.16A 4l6v1-4ce5A:
undetectable
4l6v6-4ce5A:
undetectable		 4l6v1-4ce5A:
17.52
4l6v6-4ce5A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4ce5 AT-OMEGATA
(Aspergillus
terreus) 		5 / 12 GLY A 214
GLY A 216
LEU A 211
ILE A 270
LEU A 285
 None
PDG  A1181 (-3.2A)
None
None
None
 0.98A 4n49A-4ce5A:
undetectable		 4n49A-4ce5A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4ce5 AT-OMEGATA
(Aspergillus
terreus) 		3 / 3 SER A  64
HIS A 310
TYR A 306
 None
 0.99A 5y2tA-4ce5A:
undetectable		 5y2tA-4ce5A:
undetectable