SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cek'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 4cek REGULATOR OF
NONSENSE TRANSCRIPTS
2
(Homo
sapiens) 		4 / 6 ARG A 668
GLY A 671
GLU A 672
MET A 731
 None
 1.23A 4g0vB-4cekA:
undetectable		 4g0vB-4cekA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4cek REGULATOR OF
NONSENSE TRANSCRIPTS
2
(Homo
sapiens) 		4 / 5 ILE A 660
ASP A 694
GLU A 701
VAL A 667
 None
 1.11A 4nkxC-4cekA:
undetectable		 4nkxC-4cekA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4cek REGULATOR OF
NONSENSE TRANSCRIPTS
2
(Homo
sapiens) 		4 / 5 ILE A 660
ASP A 694
GLU A 701
VAL A 667
 None
 1.16A 4nkxD-4cekA:
undetectable		 4nkxD-4cekA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4cek REGULATOR OF
NONSENSE TRANSCRIPTS
2
(Homo
sapiens) 		4 / 6 TYR A 753
PRO A 757
LEU A 728
GLU A 729
 None
 1.21A 4z4cA-4cekA:
undetectable		 4z4cA-4cekA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 4cek REGULATOR OF
NONSENSE TRANSCRIPTS
2
(Homo
sapiens) 		6 / 11 ASN A 594
ASP A 590
LEU A 564
LEU A 575
LEU A 629
LEU A 625
 None
 1.43A 4zowA-4cekA:
1.2		 4zowA-4cekA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 4cek REGULATOR OF
NONSENSE TRANSCRIPTS
2
(Homo
sapiens) 		4 / 7 LEU A 673
ASP A 585
MET A 678
LEU A 640
 None
 1.09A 5jq7B-4cekA:
undetectable		 5jq7B-4cekA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4cek REGULATOR OF
NONSENSE TRANSCRIPTS
2
(Homo
sapiens) 		5 / 12 PHE A 695
LEU A 692
LEU A 688
ALA A 703
TYR A 752
 None
 0.91A 5ljeA-4cekA:
undetectable		 5ljeA-4cekA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4cek REGULATOR OF
NONSENSE TRANSCRIPTS
2
(Homo
sapiens) 		3 / 3 CYH A 704
MET A 747
ASN A 750
 None
 1.15A 5qh8A-4cekA:
undetectable		 5qh8A-4cekA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4cek REGULATOR OF
NONSENSE TRANSCRIPTS
2
(Homo
sapiens) 		4 / 7 TYR A 753
PRO A 757
LEU A 728
GLU A 729
 None
 1.07A 5t7bA-4cekA:
undetectable		 5t7bA-4cekA:
16.13