SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cem'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4cem REGULATOR OF
NONSENSE TRANSCRIPTS
2
(Homo
sapiens) 		4 / 4 LEU A 196
LEU A 189
SER A 190
LEU A 228
 None
 1.09A 1ya3A-4cemA:
undetectable		 1ya3A-4cemA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 4cem REGULATOR OF
NONSENSE TRANSCRIPTS
2
(Homo
sapiens) 		5 / 12 VAL A 175
ASN A 171
PHE A 236
ILE A 202
TYR A 233
 None
 1.06A 3q5pA-4cemA:
1.8		 3q5pA-4cemA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 4cem REGULATOR OF
NONSENSE TRANSCRIPTS
2
(Homo
sapiens) 		5 / 9 ILE A 344
GLY A 276
ILE A 277
ILE A 287
ILE A 319
 None
 0.99A 3s43A-4cemA:
undetectable		 3s43A-4cemA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4cem REGULATOR OF
NONSENSE TRANSCRIPTS
2
(Homo
sapiens) 		3 / 3 ASP A 265
VAL A 308
ASN A 258
 None
 0.79A 4lmnA-4cemA:
undetectable		 4lmnA-4cemA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 4cem REGULATOR OF
NONSENSE TRANSCRIPTS
2
(Homo
sapiens) 		4 / 8 ILE A 259
PRO A 257
ALA A 297
ILE A 294
 None
 0.63A 5mvmA-4cemA:
3.0
5mvmB-4cemA:
2.3		 5mvmA-4cemA:
12.43
5mvmB-4cemA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 4cem REGULATOR OF
NONSENSE TRANSCRIPTS
2
(Homo
sapiens) 		3 / 3 HIS A 314
GLU A 271
ASN A 220
 None
 0.98A 5wbvA-4cemA:
undetectable		 5wbvA-4cemA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 4cem REGULATOR OF
NONSENSE TRANSCRIPTS
2
(Homo
sapiens) 		3 / 3 HIS A 314
GLU A 271
ASN A 220
 None
 0.98A 5wbvB-4cemA:
undetectable		 5wbvB-4cemA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4cem REGULATOR OF
NONSENSE TRANSCRIPTS
2
(Homo
sapiens) 		3 / 3 ARG A 325
LYS A 328
ARG A 141
 None
 1.30A 6c06D-4cemA:
3.0		 6c06D-4cemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 4cem REGULATOR OF
NONSENSE TRANSCRIPTS
2
(Homo
sapiens) 		5 / 11 PHE A 229
ILE A 202
LEU A 198
LEU A 228
ILE A 181
 None
 1.25A 6fgcA-4cemA:
undetectable		 6fgcA-4cemA:
13.45