SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cf3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 4cf3 L-HALOACID
DEHALOGENASE
(Rhodobacteraceae) 		3 / 3 ALA A  83
VAL A  77
TRP A  46
 None
 0.88A 1tkqB-4cf3A:
undetectable		 1tkqB-4cf3A:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 4cf3 L-HALOACID
DEHALOGENASE
(Rhodobacteraceae) 		3 / 3 TRP A  46
ALA A  78
VAL A  73
 None
 0.97A 2izqC-4cf3A:
undetectable
2izqD-4cf3A:
undetectable		 2izqC-4cf3A:
3.62
2izqD-4cf3A:
3.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 4cf3 L-HALOACID
DEHALOGENASE
(Rhodobacteraceae) 		4 / 8 VAL A 150
ARG A 193
GLY A 189
ALA A 190
 None
 0.88A 2xfsA-4cf3A:
undetectable		 2xfsA-4cf3A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 4cf3 L-HALOACID
DEHALOGENASE
(Rhodobacteraceae) 		4 / 8 VAL A 150
ARG A 193
GLY A 189
ALA A 190
 None
 0.86A 2xh9A-4cf3A:
undetectable		 2xh9A-4cf3A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 4cf3 L-HALOACID
DEHALOGENASE
(Rhodobacteraceae) 		4 / 6 VAL A 162
GLY A 198
ARG A 196
LEU A 230
 None
 0.98A 3bjwE-4cf3A:
undetectable		 3bjwE-4cf3A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4cf3 L-HALOACID
DEHALOGENASE
(Rhodobacteraceae) 		5 / 12 LEU A  26
LEU A  29
ILE A  51
THR A  98
VAL A  73
 None
 1.30A 4f4dA-4cf3A:
undetectable		 4f4dA-4cf3A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 4cf3 L-HALOACID
DEHALOGENASE
(Rhodobacteraceae) 		5 / 12 PHE A 144
ALA A 146
LEU A  23
GLY A  13
LEU A 113
 None
None
ASB  A  18 ( 3.8A)
None
None
 1.22A 4kykA-4cf3A:
undetectable
4kykB-4cf3A:
undetectable		 4kykA-4cf3A:
23.29
4kykB-4cf3A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_ACTA605_0
(SERUM ALBUMIN)		 4cf3 L-HALOACID
DEHALOGENASE
(Rhodobacteraceae) 		3 / 3 LYS A  19
LYS A 157
ALA A 181
 ASB  A  18 ( 3.4A)
ASB  A  18 ( 2.8A)
ASB  A  18 ( 3.5A)
 1.20A 4ot2A-4cf3A:
1.3		 4ot2A-4cf3A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_ACTA605_0
(SERUM ALBUMIN)		 4cf3 L-HALOACID
DEHALOGENASE
(Rhodobacteraceae) 		3 / 3 LYS A  19
LYS A 157
ALA A 183
 ASB  A  18 ( 3.4A)
ASB  A  18 ( 2.8A)
ASB  A  18 (-4.5A)
 1.50A 4ot2A-4cf3A:
1.3		 4ot2A-4cf3A:
17.55