SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cfh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		8 / 12 LEU A  22
GLY A  23
VAL A  30
ALA A  43
VAL A  96
ASN A 144
LEU A 146
ASP A 157
 STU  A1550 (-4.3A)
STU  A1550 (-3.1A)
None
STU  A1550 (-3.1A)
STU  A1550 (-3.8A)
STU  A1550 (-4.3A)
STU  A1550 (-4.3A)
STU  A1550 (-3.6A)
 0.84A 1fmoE-4cfhA:
31.7		 1fmoE-4cfhA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		7 / 12 LEU A  22
VAL A  30
ALA A  43
GLU A  64
GLY A  99
LEU A 146
ALA A 156
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.1A)
None
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
 0.94A 1iepA-4cfhA:
22.7		 1iepA-4cfhA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		6 / 12 LEU A  22
VAL A  30
ALA A  43
GLU A  64
GLY A  99
ALA A 156
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.1A)
None
STU  A1550 (-3.4A)
STU  A1550 ( 3.8A)
 0.98A 1iepB-4cfhA:
22.7		 1iepB-4cfhA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		4 / 6 ILE A 123
GLU A 115
LEU A 111
LEU A 204
 None
 1.04A 1mt1B-4cfhA:
undetectable
1mt1C-4cfhA:
undetectable		 1mt1B-4cfhA:
11.26
1mt1C-4cfhA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		4 / 7 ASN A 144
HIS A 137
PHE A 158
ILE A 123
 STU  A1550 (-4.3A)
None
None
None
 1.34A 1tdnA-4cfhA:
undetectable		 1tdnA-4cfhA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		6 / 9 LEU A  22
VAL A  30
ALA A  43
MET A  93
GLY A  99
LEU A 146
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.1A)
STU  A1550 (-3.7A)
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
 0.86A 1xbbA-4cfhA:
25.7		 1xbbA-4cfhA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		3 / 3 LYS A  45
ASP A 139
CYH A 174
 STU  A1550 (-3.6A)
None
TPO  A 172 ( 3.7A)
 1.43A 2br4F-4cfhA:
undetectable		 2br4F-4cfhA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		7 / 12 VAL A  30
LYS A  45
VAL A  96
ASN A 144
LEU A 146
ALA A 156
ASP A 157
 None
STU  A1550 (-3.6A)
STU  A1550 (-3.8A)
STU  A1550 (-4.3A)
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
STU  A1550 (-3.6A)
 0.66A 2eufB-4cfhA:
29.4		 2eufB-4cfhA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		9 / 12 LEU A  22
GLY A  23
VAL A  30
ALA A  43
VAL A  96
ASP A 139
LYS A 141
ASN A 144
ASP A 157
 STU  A1550 (-4.3A)
STU  A1550 (-3.1A)
None
STU  A1550 (-3.1A)
STU  A1550 (-3.8A)
None
None
STU  A1550 (-4.3A)
STU  A1550 (-3.6A)
 1.02A 2fumA-4cfhA:
29.2		 2fumA-4cfhA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		10 / 12 LEU A  22
GLY A  23
VAL A  30
ALA A  43
MET A  93
TYR A  95
VAL A  96
LYS A 141
ASN A 144
ASP A 157
 STU  A1550 (-4.3A)
STU  A1550 (-3.1A)
None
STU  A1550 (-3.1A)
STU  A1550 (-3.7A)
STU  A1550 (-4.5A)
STU  A1550 (-3.8A)
None
STU  A1550 (-4.3A)
STU  A1550 (-3.6A)
 0.95A 2fumB-4cfhA:
29.0		 2fumB-4cfhA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		8 / 12 LEU A  22
GLY A  23
VAL A  30
ALA A  43
MET A  93
TYR A  95
VAL A  96
ASN A 144
 STU  A1550 (-4.3A)
STU  A1550 (-3.1A)
None
STU  A1550 (-3.1A)
STU  A1550 (-3.7A)
STU  A1550 (-4.5A)
STU  A1550 (-3.8A)
STU  A1550 (-4.3A)
 0.77A 2fumC-4cfhA:
26.8		 2fumC-4cfhA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		7 / 12 LEU A  22
GLY A  23
VAL A  30
ALA A  43
MET A  93
LYS A 141
ASN A 144
 STU  A1550 (-4.3A)
STU  A1550 (-3.1A)
None
STU  A1550 (-3.1A)
STU  A1550 (-3.7A)
None
STU  A1550 (-4.3A)
 0.75A 2fumD-4cfhA:
27.0		 2fumD-4cfhA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		4 / 7 LEU A 207
LEU A 204
ILE A 197
ARG A 256
 None
 1.22A 2hc4A-4cfhA:
undetectable		 2hc4A-4cfhA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		6 / 12 VAL A  30
ALA A  43
GLU A  64
GLY A  99
LEU A 146
ALA A 156
 None
STU  A1550 (-3.1A)
None
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
 0.85A 2hyyA-4cfhA:
22.9		 2hyyA-4cfhA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		6 / 12 VAL A  30
ALA A  43
GLU A  64
GLY A  99
LEU A 146
ALA A 156
 None
STU  A1550 (-3.1A)
None
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
 0.82A 2hyyB-4cfhA:
22.9		 2hyyB-4cfhA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		8 / 12 VAL A  30
ALA A  43
LYS A  45
GLU A  64
TYR A  95
GLY A  99
LEU A 146
ALA A 156
 None
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
None
STU  A1550 (-4.5A)
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
 0.96A 2oiqA-4cfhA:
22.7		 2oiqA-4cfhA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		4 / 6 LEU A  22
VAL A  30
LYS A  45
LEU A 146
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.6A)
STU  A1550 (-4.3A)
 0.72A 3cs9D-4cfhA:
21.7		 3cs9D-4cfhA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		10 / 12 LEU A  22
GLY A  23
GLY A  28
VAL A  30
ALA A  43
LYS A  45
MET A  93
ASN A 144
LEU A 146
ASP A 157
 STU  A1550 (-4.3A)
STU  A1550 (-3.1A)
None
None
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
STU  A1550 (-3.7A)
STU  A1550 (-4.3A)
STU  A1550 (-4.3A)
STU  A1550 (-3.6A)
 0.93A 3eygA-4cfhA:
26.0		 3eygA-4cfhA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		5 / 12 GLY A  25
VAL A  30
LEU A  18
ILE A  61
ILE A  13
 STU  A1550 (-3.8A)
None
None
None
None
 0.98A 3frqB-4cfhA:
undetectable		 3frqB-4cfhA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		9 / 12 GLY A  23
GLY A  28
VAL A  30
ALA A  43
LYS A  45
MET A  93
TYR A  95
LEU A 146
ASP A 157
 STU  A1550 (-3.1A)
None
None
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
STU  A1550 (-3.7A)
STU  A1550 (-4.5A)
STU  A1550 (-4.3A)
STU  A1550 (-3.6A)
 0.90A 3fupA-4cfhA:
26.2		 3fupA-4cfhA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		9 / 12 LEU A  22
GLY A  23
GLY A  28
VAL A  30
ALA A  43
LYS A  45
MET A  93
TYR A  95
LEU A 146
 STU  A1550 (-4.3A)
STU  A1550 (-3.1A)
None
None
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
STU  A1550 (-3.7A)
STU  A1550 (-4.5A)
STU  A1550 (-4.3A)
 0.93A 3fupA-4cfhA:
26.2		 3fupA-4cfhA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		6 / 11 LEU A  22
VAL A  30
ALA A  43
TYR A  95
GLY A  99
LEU A 146
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.1A)
STU  A1550 (-4.5A)
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
 0.56A 3g0eA-4cfhA:
21.4		 3g0eA-4cfhA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		6 / 11 LEU A  22
VAL A  30
ALA A  43
TYR A  95
GLY A  99
LEU A 146
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.1A)
STU  A1550 (-4.5A)
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
 0.59A 3g0fA-4cfhA:
22.6		 3g0fA-4cfhA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		6 / 10 LEU A  22
VAL A  30
ALA A  43
TYR A  95
GLY A  99
LEU A 146
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.1A)
STU  A1550 (-4.5A)
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
 0.55A 3g0fB-4cfhA:
22.9		 3g0fB-4cfhA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		4 / 8 PHE A 120
PHE A 268
ILE A 197
PHE A 277
 None
 0.97A 3ko0O-4cfhA:
undetectable
3ko0Q-4cfhA:
undetectable		 3ko0O-4cfhA:
11.83
3ko0Q-4cfhA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		9 / 12 GLY A  23
VAL A  30
ALA A  43
LYS A  45
MET A  93
TYR A  95
LEU A 146
ALA A 156
ASP A 157
 STU  A1550 (-3.1A)
None
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
STU  A1550 (-3.7A)
STU  A1550 (-4.5A)
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
STU  A1550 (-3.6A)
 0.94A 3lxkA-4cfhA:
26.4		 3lxkA-4cfhA:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		8 / 12 LEU A  22
GLY A  23
VAL A  30
ALA A  43
LYS A  45
MET A  93
TYR A  95
LEU A 146
 STU  A1550 (-4.3A)
STU  A1550 (-3.1A)
None
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
STU  A1550 (-3.7A)
STU  A1550 (-4.5A)
STU  A1550 (-4.3A)
 1.01A 3lxkA-4cfhA:
26.4		 3lxkA-4cfhA:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		6 / 12 LEU A  22
VAL A  30
ALA A  43
GLU A  64
LEU A 146
ALA A 156
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.1A)
None
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
 0.98A 3ms9A-4cfhA:
17.0		 3ms9A-4cfhA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		7 / 12 LEU A  22
VAL A  30
ALA A  43
GLU A  64
GLY A  99
LEU A 146
ALA A 156
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.1A)
None
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
 0.93A 3ms9B-4cfhA:
22.4		 3ms9B-4cfhA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		7 / 12 VAL A  30
ALA A  43
LYS A  45
GLU A  64
TYR A  95
LEU A 146
ALA A 156
 None
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
None
STU  A1550 (-4.5A)
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
 0.79A 3oezB-4cfhA:
17.1		 3oezB-4cfhA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		5 / 9 LEU A  22
ILE A  76
MET A  91
TYR A  95
ILE A 155
 STU  A1550 (-4.3A)
None
None
STU  A1550 (-4.5A)
None
 0.72A 3zosB-4cfhA:
22.4		 3zosB-4cfhA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		7 / 12 VAL A  30
ALA A  43
GLU A  64
ILE A  77
MET A  91
LEU A 146
ALA A 156
 None
STU  A1550 (-3.1A)
None
STU  A1550 ( 4.3A)
None
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
 1.18A 4bkjA-4cfhA:
17.6		 4bkjA-4cfhA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		7 / 12 VAL A  30
ALA A  43
GLU A  64
MET A  91
TYR A  95
LEU A 146
ALA A 156
 None
STU  A1550 (-3.1A)
None
None
STU  A1550 (-4.5A)
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
 1.13A 4bkjA-4cfhA:
17.6		 4bkjA-4cfhA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		6 / 12 VAL A  30
ALA A  43
GLU A  64
MET A  91
LEU A 146
ALA A 156
 None
STU  A1550 (-3.1A)
None
None
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
 1.06A 4bkjB-4cfhA:
22.4		 4bkjB-4cfhA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		4 / 5 VAL A  30
ILE A  76
TYR A  95
ILE A 155
 None
None
STU  A1550 (-4.5A)
None
 0.46A 4c8bA-4cfhA:
23.4		 4c8bA-4cfhA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		7 / 12 ALA A  43
LYS A  45
GLU A  64
LEU A  68
ILE A  76
LEU A 146
ALA A 156
 STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
None
None
None
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
 0.75A 4c8bB-4cfhA:
23.5		 4c8bB-4cfhA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		7 / 12 ALA A  43
LYS A  45
LEU A  68
ILE A  76
HIS A 137
LEU A 146
ALA A 156
 STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
None
None
None
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
 0.76A 4c8bB-4cfhA:
23.5		 4c8bB-4cfhA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		9 / 12 VAL A  30
ALA A  43
ILE A  77
ASP A 103
ASP A 139
LYS A 141
ASN A 144
LEU A 146
ASP A 157
 None
STU  A1550 (-3.1A)
STU  A1550 ( 4.3A)
None
None
None
STU  A1550 (-4.3A)
STU  A1550 (-4.3A)
STU  A1550 (-3.6A)
 0.63A 4i41A-4cfhA:
29.7		 4i41A-4cfhA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		6 / 12 VAL A  30
ALA A  43
LEU A  79
GLY A  99
GLU A 100
LEU A 146
 None
STU  A1550 (-3.1A)
None
STU  A1550 (-3.4A)
STU  A1550 (-3.6A)
STU  A1550 (-4.3A)
 0.52A 4ifgA-4cfhA:
21.0		 4ifgA-4cfhA:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		7 / 12 LEU A  22
GLY A  25
VAL A  30
ALA A  43
GLY A  99
LEU A 146
ASP A 157
 STU  A1550 (-4.3A)
STU  A1550 (-3.8A)
None
STU  A1550 (-3.1A)
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
STU  A1550 (-3.6A)
 0.88A 4mkcA-4cfhA:
23.6		 4mkcA-4cfhA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		7 / 12 LEU A  22
GLY A  25
VAL A  30
ALA A  43
LYS A  45
GLY A  99
ASP A 157
 STU  A1550 (-4.3A)
STU  A1550 (-3.8A)
None
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
STU  A1550 (-3.4A)
STU  A1550 (-3.6A)
 0.89A 4mkcA-4cfhA:
23.6		 4mkcA-4cfhA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		8 / 12 LEU A  22
VAL A  30
ALA A  43
LYS A  45
TYR A  95
GLY A  99
LEU A 146
ASP A 157
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
STU  A1550 (-4.5A)
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
STU  A1550 (-3.6A)
 0.99A 4mxyB-4cfhA:
24.6		 4mxyB-4cfhA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		8 / 12 VAL A  30
ALA A  43
LYS A  45
TYR A  95
GLY A  99
LEU A 146
ALA A 156
ASP A 157
 None
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
STU  A1550 (-4.5A)
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
STU  A1550 (-3.6A)
 0.96A 4mxyB-4cfhA:
24.6		 4mxyB-4cfhA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		8 / 12 LEU A  22
VAL A  30
ALA A  43
LYS A  45
TYR A  95
GLY A  99
LEU A 146
ASP A 157
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
STU  A1550 (-4.5A)
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
STU  A1550 (-3.6A)
 0.99A 4mxzB-4cfhA:
24.6		 4mxzB-4cfhA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		8 / 12 VAL A  30
ALA A  43
LYS A  45
TYR A  95
GLY A  99
LEU A 146
ALA A 156
ASP A 157
 None
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
STU  A1550 (-4.5A)
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
STU  A1550 (-3.6A)
 0.96A 4mxzB-4cfhA:
24.6		 4mxzB-4cfhA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		6 / 8 GLY A  25
VAL A  30
ALA A  43
ASN A 144
LEU A 146
ASP A 157
 STU  A1550 (-3.8A)
None
STU  A1550 (-3.1A)
STU  A1550 (-4.3A)
STU  A1550 (-4.3A)
STU  A1550 (-3.6A)
 0.77A 4ogrA-4cfhA:
28.7		 4ogrA-4cfhA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		5 / 7 GLY A  23
ALA A  43
ASN A 144
LEU A 146
ASP A 157
 STU  A1550 (-3.1A)
STU  A1550 (-3.1A)
STU  A1550 (-4.3A)
STU  A1550 (-4.3A)
STU  A1550 (-3.6A)
 0.80A 4ogrE-4cfhA:
27.7		 4ogrE-4cfhA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		6 / 9 GLY A  25
VAL A  30
ALA A  43
ASN A 144
LEU A 146
ASP A 157
 STU  A1550 (-3.8A)
None
STU  A1550 (-3.1A)
STU  A1550 (-4.3A)
STU  A1550 (-4.3A)
STU  A1550 (-3.6A)
 0.81A 4ogrI-4cfhA:
28.3		 4ogrI-4cfhA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		8 / 12 LEU A  22
GLY A  23
GLY A  28
VAL A  30
ALA A  43
LYS A  45
LEU A 146
ALA A 156
 STU  A1550 (-4.3A)
STU  A1550 (-3.1A)
None
None
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
 0.68A 4otiA-4cfhA:
25.2		 4otiA-4cfhA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		8 / 12 LEU A  22
VAL A  30
LYS A  45
TYR A  95
GLY A  99
LEU A 146
ALA A 156
ASP A 157
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.6A)
STU  A1550 (-4.5A)
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
STU  A1550 (-3.6A)
 0.99A 4otwA-4cfhA:
22.4		 4otwA-4cfhA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		6 / 12 ALA A  43
GLU A  64
TYR A  95
LEU A 146
ALA A 156
ASP A 157
 STU  A1550 (-3.1A)
None
STU  A1550 (-4.5A)
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
STU  A1550 (-3.6A)
 0.55A 4qmnA-4cfhA:
30.3		 4qmnA-4cfhA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		7 / 12 ALA A  43
LYS A  45
GLU A  64
MET A  93
TYR A  95
LEU A 146
ALA A 156
 STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
None
STU  A1550 (-3.7A)
STU  A1550 (-4.5A)
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
 0.93A 4qmnA-4cfhA:
30.3		 4qmnA-4cfhA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		6 / 11 ALA A  43
GLU A  64
MET A  93
TYR A  95
LEU A 146
ASP A 157
 STU  A1550 (-3.1A)
None
STU  A1550 (-3.7A)
STU  A1550 (-4.5A)
STU  A1550 (-4.3A)
STU  A1550 (-3.6A)
 0.79A 4qmsA-4cfhA:
22.1		 4qmsA-4cfhA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		6 / 11 ALA A  43
LYS A  45
GLU A  64
TYR A  95
LEU A 146
ASP A 157
 STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
None
STU  A1550 (-4.5A)
STU  A1550 (-4.3A)
STU  A1550 (-3.6A)
 0.71A 4qmsA-4cfhA:
22.1		 4qmsA-4cfhA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		6 / 12 GLY A  23
VAL A  30
ALA A  43
MET A  93
TYR A  95
LEU A 146
 STU  A1550 (-3.1A)
None
STU  A1550 (-3.1A)
STU  A1550 (-3.7A)
STU  A1550 (-4.5A)
STU  A1550 (-4.3A)
 0.79A 4qmzA-4cfhA:
19.9		 4qmzA-4cfhA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		5 / 10 ALA A  43
LYS A  45
ILE A  77
VAL A  96
LEU A 146
 STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
STU  A1550 ( 4.3A)
STU  A1550 (-3.8A)
STU  A1550 (-4.3A)
 0.87A 4rz7A-4cfhA:
11.1		 4rz7A-4cfhA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		9 / 12 LEU A  22
VAL A  30
ALA A  43
LYS A  45
GLY A  99
ASN A 144
LEU A 146
ALA A 156
ASP A 157
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
STU  A1550 (-3.6A)
 0.71A 4twpA-4cfhA:
25.4		 4twpA-4cfhA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		8 / 12 LEU A  22
VAL A  30
ALA A  43
GLY A  99
ASN A 144
LEU A 146
ALA A 156
ASP A 157
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.1A)
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
STU  A1550 (-3.6A)
 0.74A 4twpB-4cfhA:
25.7		 4twpB-4cfhA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		8 / 12 LEU A  22
VAL A  30
ALA A  43
LYS A  45
GLY A  99
ASN A 144
LEU A 146
ALA A 156
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
 0.81A 4twpB-4cfhA:
25.7		 4twpB-4cfhA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		4 / 6 VAL A  30
ILE A  76
ARG A 138
ILE A 155
 None
None
TPO  A 172 ( 2.4A)
None
 0.70A 4tyjA-4cfhA:
23.5		 4tyjA-4cfhA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		6 / 10 LEU A  22
VAL A  30
ILE A  76
TYR A  95
ARG A 138
ILE A 155
 STU  A1550 (-4.3A)
None
None
STU  A1550 (-4.5A)
TPO  A 172 ( 2.4A)
None
 0.78A 4u0iA-4cfhA:
22.3		 4u0iA-4cfhA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		8 / 11 LEU A  22
VAL A  30
ALA A  43
TYR A  95
GLY A  99
ASN A 144
LEU A 146
ALA A 156
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.1A)
STU  A1550 (-4.5A)
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
 0.69A 4u5jA-4cfhA:
25.8		 4u5jA-4cfhA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		8 / 11 VAL A  30
ALA A  43
TYR A  95
GLY A  99
ASN A 144
LEU A 146
ALA A 156
ASP A 157
 None
STU  A1550 (-3.1A)
STU  A1550 (-4.5A)
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
STU  A1550 (-3.6A)
 0.67A 4u5jA-4cfhA:
25.8		 4u5jA-4cfhA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		6 / 9 LEU A  22
VAL A  30
ALA A  43
TYR A  95
GLY A  99
LEU A 146
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.1A)
STU  A1550 (-4.5A)
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
 0.68A 4u5jB-4cfhA:
18.4		 4u5jB-4cfhA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		7 / 9 LEU A  22
VAL A  30
ILE A  77
TYR A  95
ARG A 138
LEU A 146
ILE A 155
 STU  A1550 (-4.3A)
None
STU  A1550 ( 4.3A)
STU  A1550 (-4.5A)
TPO  A 172 ( 2.4A)
STU  A1550 (-4.3A)
None
 0.84A 4v01A-4cfhA:
22.8		 4v01A-4cfhA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		7 / 9 LEU A  22
VAL A  30
LYS A  45
ILE A  77
TYR A  95
ARG A 138
LEU A 146
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.6A)
STU  A1550 ( 4.3A)
STU  A1550 (-4.5A)
TPO  A 172 ( 2.4A)
STU  A1550 (-4.3A)
 0.93A 4v01A-4cfhA:
22.8		 4v01A-4cfhA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		6 / 9 LEU A  22
VAL A  30
LYS A  45
ILE A  77
TYR A  95
ILE A  76
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.6A)
STU  A1550 ( 4.3A)
STU  A1550 (-4.5A)
None
 1.21A 4v01A-4cfhA:
22.8		 4v01A-4cfhA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		7 / 9 LEU A  22
VAL A  30
LYS A  45
ILE A  77
TYR A  95
LEU A 146
ILE A 155
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.6A)
STU  A1550 ( 4.3A)
STU  A1550 (-4.5A)
STU  A1550 (-4.3A)
None
 0.86A 4v01B-4cfhA:
23.2		 4v01B-4cfhA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		7 / 9 VAL A  30
LYS A  45
ILE A  77
TYR A  95
ARG A 138
LEU A 146
ILE A 155
 None
STU  A1550 (-3.6A)
STU  A1550 ( 4.3A)
STU  A1550 (-4.5A)
TPO  A 172 ( 2.4A)
STU  A1550 (-4.3A)
None
 0.84A 4v01B-4cfhA:
23.2		 4v01B-4cfhA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		5 / 8 ILE A  77
TYR A  95
ARG A 138
LEU A 146
ILE A 155
 STU  A1550 ( 4.3A)
STU  A1550 (-4.5A)
TPO  A 172 ( 2.4A)
STU  A1550 (-4.3A)
None
 0.96A 4v04A-4cfhA:
22.7		 4v04A-4cfhA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		5 / 8 LYS A  45
ILE A  77
TYR A  95
ARG A 138
LEU A 146
 STU  A1550 (-3.6A)
STU  A1550 ( 4.3A)
STU  A1550 (-4.5A)
TPO  A 172 ( 2.4A)
STU  A1550 (-4.3A)
 1.08A 4v04A-4cfhA:
22.7		 4v04A-4cfhA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		8 / 10 LEU A  22
VAL A  30
LYS A  45
ILE A  77
TYR A  95
ARG A 138
LEU A 146
ILE A 155
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.6A)
STU  A1550 ( 4.3A)
STU  A1550 (-4.5A)
TPO  A 172 ( 2.4A)
STU  A1550 (-4.3A)
None
 0.96A 4v04B-4cfhA:
23.0		 4v04B-4cfhA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		6 / 10 LEU A  22
VAL A  30
LYS A  45
ILE A  77
TYR A  95
ILE A  76
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.6A)
STU  A1550 ( 4.3A)
STU  A1550 (-4.5A)
None
 1.17A 4v04B-4cfhA:
23.0		 4v04B-4cfhA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		4 / 6 LEU A  22
ALA A  43
MET A  93
LEU A 146
 STU  A1550 (-4.3A)
STU  A1550 (-3.1A)
STU  A1550 (-3.7A)
STU  A1550 (-4.3A)
 0.70A 4wboC-4cfhA:
29.0		 4wboC-4cfhA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		7 / 10 LEU A  22
VAL A  30
ALA A  43
LYS A  45
GLY A  99
LEU A 146
ASP A 157
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
STU  A1550 (-3.6A)
 1.05A 5aabA-4cfhA:
23.0		 5aabA-4cfhA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		6 / 12 LEU A  22
ALA A  43
GLY A  99
LEU A 146
ALA A 156
ASP A 157
 STU  A1550 (-4.3A)
STU  A1550 (-3.1A)
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
STU  A1550 (-3.6A)
 0.82A 5ajqA-4cfhA:
24.5		 5ajqA-4cfhA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		8 / 12 LEU A  22
VAL A  30
ALA A  43
LYS A  45
ILE A  77
GLY A  99
LEU A 146
ALA A 156
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
STU  A1550 ( 4.3A)
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
 0.90A 5bvwA-4cfhA:
22.5		 5bvwA-4cfhA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		8 / 12 LEU A  22
VAL A  30
ALA A  43
LYS A  45
TYR A  95
GLY A  99
LEU A 146
ALA A 156
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
STU  A1550 (-4.5A)
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
 0.85A 5bvwA-4cfhA:
22.5		 5bvwA-4cfhA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		8 / 12 VAL A  30
ALA A  43
LYS A  45
GLU A  64
TYR A  95
GLY A  99
LEU A 146
ALA A 156
 None
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
None
STU  A1550 (-4.5A)
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
 0.83A 5bvwA-4cfhA:
22.5		 5bvwA-4cfhA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		6 / 12 GLY A  23
GLY A  25
VAL A  30
ALA A  43
LYS A  45
ASP A 157
 STU  A1550 (-3.1A)
STU  A1550 (-3.8A)
None
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
STU  A1550 (-3.6A)
 1.09A 5hieC-4cfhA:
23.8		 5hieC-4cfhA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		7 / 12 GLY A  23
VAL A  30
ALA A  43
LYS A  45
GLU A  64
TYR A  95
GLY A  99
 STU  A1550 (-3.1A)
None
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
None
STU  A1550 (-4.5A)
STU  A1550 (-3.4A)
 0.81A 5mafA-4cfhA:
32.1		 5mafA-4cfhA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		7 / 10 LEU A  22
VAL A  30
ALA A  43
MET A  93
TYR A  95
VAL A  96
LEU A 146
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.1A)
STU  A1550 (-3.7A)
STU  A1550 (-4.5A)
STU  A1550 (-3.8A)
STU  A1550 (-4.3A)
 0.70A 5n3hA-4cfhA:
31.5		 5n3hA-4cfhA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		4 / 5 LYS A  60
ARG A  63
ARG A 138
LEU A 160
 TPO  A 172 ( 3.5A)
TPO  A 172 ( 3.6A)
TPO  A 172 ( 2.4A)
None
 0.70A 5osrA-4cfhA:
6.8		 5osrA-4cfhA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		4 / 5 LYS A  60
ARG A  63
ARG A 138
LEU A 160
 TPO  A 172 ( 3.5A)
TPO  A 172 ( 3.6A)
TPO  A 172 ( 2.4A)
None
 0.77A 5otrA-4cfhA:
7.8		 5otrA-4cfhA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		4 / 5 TYR A 190
VAL A 195
PRO A 253
ALA A 181
 None
 0.96A 5otrA-4cfhA:
8.3		 5otrA-4cfhA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		4 / 8 ALA A  43
GLU A  64
LEU A 146
ASP A 157
 STU  A1550 (-3.1A)
None
STU  A1550 (-4.3A)
STU  A1550 (-3.6A)
 0.45A 5owrA-4cfhA:
22.7		 5owrA-4cfhA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus;
Rattus
norvegicus) 		5 / 10 LEU A 398
ILE C 543
LEU C 546
LEU A 432
LEU A 451
 None
 1.26A 5y7pB-4cfhA:
undetectable		 5y7pB-4cfhA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus;
Rattus
norvegicus) 		5 / 10 LEU A 398
ILE C 543
LEU C 546
LEU A 432
LEU A 451
 None
 1.28A 5y7pD-4cfhA:
undetectable		 5y7pD-4cfhA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		7 / 12 LEU A  22
VAL A  30
ALA A  43
LYS A  45
GLU A  64
GLY A  99
LEU A 146
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
None
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
 0.79A 5y7zA-4cfhA:
26.2		 5y7zA-4cfhA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		7 / 12 LEU A  22
VAL A  30
ALA A  43
LYS A  45
GLU A  64
GLY A  99
LEU A 146
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
None
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
 0.79A 5y7zA-4cfhA:
26.2		 5y7zA-4cfhA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		7 / 12 LEU A  22
ALA A  43
LYS A  45
GLU A  64
GLY A  99
LEU A 146
ASP A 157
 STU  A1550 (-4.3A)
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
None
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
STU  A1550 (-3.6A)
 0.78A 5y7zB-4cfhA:
26.3		 5y7zB-4cfhA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		7 / 12 VAL A  30
ALA A  43
LYS A  45
GLU A  64
GLY A  99
LEU A 146
ASP A 157
 None
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
None
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
STU  A1550 (-3.6A)
 0.61A 5y80A-4cfhA:
25.6		 5y80A-4cfhA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		6 / 12 LEU A  22
VAL A  30
ALA A  43
TYR A  95
GLY A  99
ALA A 156
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.1A)
STU  A1550 (-4.5A)
STU  A1550 (-3.4A)
STU  A1550 ( 3.8A)
 0.75A 5zv2A-4cfhA:
22.9		 5zv2A-4cfhA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		6 / 12 LEU A  22
VAL A  30
ALA A  43
LYS A  45
GLY A  99
ALA A 156
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
STU  A1550 (-3.4A)
STU  A1550 ( 3.8A)
 0.71A 5zv2B-4cfhA:
23.1		 5zv2B-4cfhA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		3 / 3 TYR A  95
LEU A 146
ASP A 157
 STU  A1550 (-4.5A)
STU  A1550 (-4.3A)
STU  A1550 (-3.6A)
 0.83A 5zv2B-4cfhA:
23.1		 5zv2B-4cfhA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		7 / 12 VAL A  30
ALA A  43
LYS A  45
GLU A  64
TYR A  95
GLY A  99
LEU A 146
 None
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
None
STU  A1550 (-4.5A)
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
 0.64A 6bsdA-4cfhA:
14.8		 6bsdA-4cfhA:
10.55