SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cg1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 4cg1 CUTINASE
(Thermobifida
fusca) 		5 / 11 PRO A 154
LEU A 137
VAL A 166
VAL A 126
LEU A 192
 None
 1.34A 1fkpA-4cg1A:
undetectable		 1fkpA-4cg1A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 4cg1 CUTINASE
(Thermobifida
fusca) 		4 / 8 GLU A  98
ASP A  91
ILE A  87
THR A  88
 None
 0.84A 1hmyA-4cg1A:
4.5		 1hmyA-4cg1A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4cg1 CUTINASE
(Thermobifida
fusca) 		5 / 12 TRP A  69
LEU A 203
ILE A 218
ILE A  67
LEU A  70
 None
 1.19A 1kyvA-4cg1A:
4.4
1kyvE-4cg1A:
4.2		 1kyvA-4cg1A:
23.19
1kyvE-4cg1A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4cg1 CUTINASE
(Thermobifida
fusca) 		5 / 12 ILE A  67
LEU A  70
TRP A  69
LEU A 203
ILE A 218
 None
 1.18A 1kyvB-4cg1A:
4.3
1kyvC-4cg1A:
4.2		 1kyvB-4cg1A:
23.19
1kyvC-4cg1A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4cg1 CUTINASE
(Thermobifida
fusca) 		5 / 12 ILE A  67
LEU A  70
TRP A  69
LEU A 203
ILE A 218
 None
 1.20A 1kyvC-4cg1A:
4.2
1kyvD-4cg1A:
4.4		 1kyvC-4cg1A:
23.19
1kyvD-4cg1A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4cg1 CUTINASE
(Thermobifida
fusca) 		5 / 12 ILE A  67
LEU A  70
TRP A  69
LEU A 203
ILE A 218
 None
 1.17A 1kyvD-4cg1A:
4.4
1kyvE-4cg1A:
4.2		 1kyvD-4cg1A:
23.19
1kyvE-4cg1A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 4cg1 CUTINASE
(Thermobifida
fusca) 		4 / 4 GLY A  59
SER A 130
ILE A 178
HIS A 208
 None
 1.22A 1yajJ-4cg1A:
8.3		 1yajJ-4cg1A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 4cg1 CUTINASE
(Thermobifida
fusca) 		5 / 12 VAL A 181
ASN A 215
ILE A 218
ILE A 171
HIS A 129
 None
 1.02A 2ft9A-4cg1A:
undetectable		 2ft9A-4cg1A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4cg1 CUTINASE
(Thermobifida
fusca) 		4 / 5 PRO A 180
PRO A 154
ILE A 170
GLY A 172
 None
 1.10A 2jkjD-4cg1A:
undetectable		 2jkjD-4cg1A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4cg1 CUTINASE
(Thermobifida
fusca) 		4 / 5 PRO A 180
PRO A 154
ILE A 170
GLY A 172
 None
 1.10A 2jkjF-4cg1A:
undetectable		 2jkjF-4cg1A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4cg1 CUTINASE
(Thermobifida
fusca) 		4 / 7 ALA A 206
ASN A 215
PRO A 211
ALA A 210
 None
 1.08A 2zgwA-4cg1A:
undetectable		 2zgwA-4cg1A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4cg1 CUTINASE
(Thermobifida
fusca) 		4 / 6 ALA A 206
ASN A 215
PRO A 211
ALA A 210
 None
 1.12A 2zgwB-4cg1A:
undetectable		 2zgwB-4cg1A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEE_A_T27A561_1
(P66 REVERSE
TRANSCRIPTASE)		 4cg1 CUTINASE
(Thermobifida
fusca) 		5 / 12 PRO A 154
LEU A 137
VAL A 166
VAL A 126
LEU A 192
 None
 1.32A 3meeA-4cg1A:
1.5		 3meeA-4cg1A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 4cg1 CUTINASE
(Thermobifida
fusca) 		5 / 11 VAL A  54
ALA A  53
GLY A  52
TYR A  51
ALA A 111
 None
 1.41A 3qxyB-4cg1A:
undetectable
3qxyQ-4cg1A:
undetectable		 3qxyB-4cg1A:
22.07
3qxyQ-4cg1A:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4cg1 CUTINASE
(Thermobifida
fusca) 		4 / 8 LEU A 137
VAL A 166
VAL A 126
LEU A 192
 None
 1.05A 3v81C-4cg1A:
1.4		 3v81C-4cg1A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 4cg1 CUTINASE
(Thermobifida
fusca) 		4 / 6 GLY A  78
ARG A 123
GLU A   5
ARG A 235
 None
 1.14A 4bqfA-4cg1A:
3.1		 4bqfA-4cg1A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4cg1 CUTINASE
(Thermobifida
fusca) 		4 / 8 LEU A 137
VAL A 166
VAL A 126
LEU A 192
 None
 1.07A 4q0bA-4cg1A:
1.8		 4q0bA-4cg1A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 4cg1 CUTINASE
(Thermobifida
fusca) 		5 / 12 GLY A 128
ILE A  74
GLY A 219
ILE A  56
ILE A 171
 None
 0.96A 4q5mA-4cg1A:
undetectable		 4q5mA-4cg1A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 4cg1 CUTINASE
(Thermobifida
fusca) 		4 / 7 ILE A 171
ALA A 210
ASN A 215
ILE A 218
 None
 0.87A 4y03A-4cg1A:
undetectable		 4y03A-4cg1A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 4cg1 CUTINASE
(Thermobifida
fusca) 		3 / 3 THR A  11
ASP A  12
ALA A  13
 None
 0.06A 5g5gB-4cg1A:
undetectable		 5g5gB-4cg1A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4cg1 CUTINASE
(Thermobifida
fusca) 		5 / 12 ILE A  74
GLY A  71
ASP A 231
ILE A 119
MET A 107
 None
 1.22A 5igwA-4cg1A:
undetectable		 5igwA-4cg1A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XPR_A_K86A1201_1
(ENDOTHELIN B
RECEPTOR,ENDOLYSIN,E
NDOTHELIN B RECEPTOR)		 4cg1 CUTINASE
(Thermobifida
fusca) 		5 / 12 VAL A 230
LEU A 104
ARG A 143
ILE A 108
ALA A  53
 None
 1.31A 5xprA-4cg1A:
undetectable		 5xprA-4cg1A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNK_B_NCTB402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4cg1 CUTINASE
(Thermobifida
fusca) 		4 / 7 TYR A 189
CSS A 259
CSS A 241
TYR A 255
 None
 1.29A 6cnkB-4cg1A:
undetectable
6cnkC-4cg1A:
undetectable		 6cnkB-4cg1A:
12.27
6cnkC-4cg1A:
16.41