SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cg4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B2I_A_AMHA84_1
(PROTEIN
(PLASMINOGEN))		 4cg4 PYRIN
(Homo
sapiens) 		4 / 7 ASP A 603
GLU A 605
PHE A 636
ARG A 676
 None
 1.27A 1b2iA-4cg4A:
undetectable		 1b2iA-4cg4A:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ILQ_C_ACAC7_1
(INTERLEUKIN-8
PRECURSOR
INTERLEUKIN-8
RECEPTOR A)		 4cg4 PYRIN
(Homo
sapiens) 		4 / 6 HIS A 596
PHE A 721
ASP A 723
PRO A 588
 None
 1.46A 1ilqA-4cg4A:
undetectable
1ilqC-4cg4A:
undetectable		 1ilqA-4cg4A:
13.13
1ilqC-4cg4A:
3.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4cg4 PYRIN
(Homo
sapiens) 		5 / 10 VAL A 659
GLY A 660
THR A 735
ASN A 733
VAL A 718
 None
 1.28A 1pwyE-4cg4A:
undetectable		 1pwyE-4cg4A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4cg4 PYRIN
(Homo
sapiens) 		4 / 8 GLY A 660
ILE A 720
VAL A 775
TYR A 654
 None
 0.87A 2yoeB-4cg4A:
3.9
2yoeC-4cg4A:
3.9		 2yoeB-4cg4A:
20.10
2yoeC-4cg4A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4cg4 PYRIN
(Homo
sapiens) 		3 / 3 ALA A 457
ARG A 461
LYS A 465
 None
 0.96A 3kp5B-4cg4A:
3.4		 3kp5B-4cg4A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 4cg4 PYRIN
(Homo
sapiens) 		3 / 3 THR A 771
ASP A 616
GLU A 784
 None
 0.74A 3qowA-4cg4A:
undetectable		 3qowA-4cg4A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 4cg4 PYRIN
(Homo
sapiens) 		5 / 12 LEU A 611
LEU A 643
GLY A 644
ILE A 755
ALA A 669
 None
 1.03A 3uwlD-4cg4A:
undetectable		 3uwlD-4cg4A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4cg4 PYRIN
(Homo
sapiens) 		5 / 11 THR A 606
ALA A 607
LEU A 611
VAL A 690
ILE A 674
 None
 1.43A 4claA-4cg4A:
undetectable		 4claA-4cg4A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 4cg4 PYRIN
(Homo
sapiens) 		4 / 7 PHE A 613
LEU A 617
GLU A 605
VAL A 642
 None
 0.92A 4wnvD-4cg4A:
undetectable		 4wnvD-4cg4A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4cg4 PYRIN
(Homo
sapiens) 		4 / 4 VAL A 691
ILE A 720
ASN A 733
VAL A 659
 None
 1.29A 5ajqA-4cg4A:
undetectable		 5ajqA-4cg4A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 4cg4 PYRIN
(Homo
sapiens) 		3 / 3 THR A 771
ASP A 616
GLU A 784
 None
 0.66A 5fa8A-4cg4A:
undetectable		 5fa8A-4cg4A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 4cg4 PYRIN
(Homo
sapiens) 		5 / 12 GLY A 668
VAL A 722
SER A 757
VAL A 690
LEU A 682
 None
 1.17A 5ubbA-4cg4A:
undetectable		 5ubbA-4cg4A:
23.02