SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cgk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 4cgk SECRETED 45 KDA
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 SER A 361
GLU A 360
ARG A 373
ALA A 332
ILE A 333
 None
 1.26A 1s14B-4cgkA:
undetectable		 1s14B-4cgkA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4cgk SECRETED 45 KDA
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 THR A 293
ASP A 338
SER A 382
 None
 0.80A 2nxeA-4cgkA:
undetectable		 2nxeA-4cgkA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4cgk SECRETED 45 KDA
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 THR A 293
ASP A 338
SER A 382
 None
 0.75A 2nxeB-4cgkA:
undetectable		 2nxeB-4cgkA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4cgk SECRETED 45 KDA
PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 TYR A 287
VAL A 296
ILE A 389
TRP A 307
 None
 1.09A 4xo7B-4cgkA:
undetectable		 4xo7B-4cgkA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 4cgk SECRETED 45 KDA
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 GLU A 227
GLU A 195
ALA A 198
LYS A 197
 None
 0.97A 6an0A-4cgkA:
undetectable		 6an0A-4cgkA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 4cgk SECRETED 45 KDA
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 ARG A 242
ALA A 188
THR A 191
ALA A 236
 None
 1.02A 6ma6A-4cgkA:
2.4		 6ma6A-4cgkA:
9.16