SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cgn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 4cgn GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Leishmania
major) 		5 / 12 LEU A 180
LEU A 184
ALA A 124
LEU A 122
ILE A  52
 MG  A 999 ( 4.3A)
None
None
None
None
 1.01A 1crbA-4cgnA:
undetectable		 1crbA-4cgnA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 4cgn GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Leishmania
major) 		5 / 12 PHE A 168
LEU A  97
ALA A 100
TYR A 345
ILE A 328
 None
None
None
7AH  A1000 (-4.7A)
None
 1.26A 1mx8A-4cgnA:
undetectable		 1mx8A-4cgnA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 4cgn GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Leishmania
major) 		5 / 10 LEU A 264
ALA A 367
VAL A 313
LEU A 359
GLN A 358
 None
 1.24A 1rlbE-4cgnA:
undetectable		 1rlbE-4cgnA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4cgn GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Leishmania
major) 		4 / 5 GLY A 397
GLN A 216
VAL A 378
SER A 214
 None
None
7AH  A1000 (-4.8A)
None
 1.44A 1rs6B-4cgnA:
undetectable		 1rs6B-4cgnA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4cgn GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Leishmania
major) 		4 / 5 GLY A 397
GLN A 216
VAL A 378
SER A 214
 None
None
7AH  A1000 (-4.8A)
None
 1.30A 1zzqB-4cgnA:
undetectable		 1zzqB-4cgnA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 4cgn GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Leishmania
major) 		4 / 8 THR A 137
PRO A 138
ALA A 145
PRO A 409
 None
 0.96A 2v32A-4cgnA:
undetectable
2v32B-4cgnA:
undetectable		 2v32A-4cgnA:
21.68
2v32B-4cgnA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 4cgn GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Leishmania
major) 		4 / 6 ARG A 115
ASP A  68
ILE A  69
TYR A 106
 None
 1.28A 2ya7C-4cgnA:
undetectable		 2ya7C-4cgnA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 4cgn GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Leishmania
major) 		3 / 3 THR A 310
SER A 324
PHE A 372
 None
 0.74A 3d4sA-4cgnA:
undetectable		 3d4sA-4cgnA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 4cgn GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Leishmania
major) 		5 / 10 SER A 221
ILE A 235
PRO A 236
SER A 233
GLY A 234
 None
 1.41A 3ijxB-4cgnA:
undetectable
3ijxD-4cgnA:
undetectable		 3ijxB-4cgnA:
20.40
3ijxD-4cgnA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 4cgn GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Leishmania
major) 		5 / 10 ILE A 235
PRO A 236
SER A 233
GLY A 234
SER A 221
 None
 1.44A 3ik6B-4cgnA:
undetectable
3ik6E-4cgnA:
undetectable		 3ik6B-4cgnA:
20.40
3ik6E-4cgnA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 4cgn GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Leishmania
major) 		5 / 10 SER A 221
ILE A 235
PRO A 236
SER A 233
GLY A 234
 None
 1.32A 3ik6B-4cgnA:
undetectable
3ik6E-4cgnA:
undetectable		 3ik6B-4cgnA:
20.40
3ik6E-4cgnA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 4cgn GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Leishmania
major) 		5 / 10 SER A 221
ILE A 235
PRO A 236
SER A 233
GLY A 234
 None
 1.35A 3iluB-4cgnA:
undetectable
3iluE-4cgnA:
undetectable		 3iluB-4cgnA:
20.40
3iluE-4cgnA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 4cgn GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Leishmania
major) 		5 / 11 ILE A 235
PRO A 236
SER A 233
GLY A 234
SER A 221
 None
 1.39A 3iluB-4cgnA:
undetectable
3iluE-4cgnA:
undetectable		 3iluB-4cgnA:
20.40
3iluE-4cgnA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 4cgn GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Leishmania
major) 		5 / 9 TYR A 326
HIS A 347
LEU A 418
LEU A 101
VAL A 201
 None
 1.29A 3jwqA-4cgnA:
undetectable		 3jwqA-4cgnA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 4cgn GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Leishmania
major) 		4 / 7 TYR A 326
HIS A 347
LEU A 101
VAL A 201
 None
 1.13A 3jwqC-4cgnA:
undetectable		 3jwqC-4cgnA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 4cgn GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Leishmania
major) 		5 / 12 PHE A 309
ALA A 343
ILE A 328
LEU A 341
LEU A 222
 None
 1.40A 3lcvB-4cgnA:
undetectable		 3lcvB-4cgnA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 4cgn GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Leishmania
major) 		5 / 8 ILE A 235
PRO A 236
SER A 233
GLY A 234
SER A 221
 None
 1.33A 3lslA-4cgnA:
undetectable
3lslD-4cgnA:
undetectable		 3lslA-4cgnA:
20.40
3lslD-4cgnA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 4cgn GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Leishmania
major) 		5 / 8 SER A 221
ILE A 235
PRO A 236
SER A 233
GLY A 234
 None
 1.35A 3lslA-4cgnA:
undetectable
3lslD-4cgnA:
undetectable		 3lslA-4cgnA:
20.40
3lslD-4cgnA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 4cgn GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Leishmania
major) 		4 / 5 PHE A  88
ILE A 328
ASN A 337
PHE A  90
 None
None
None
7AH  A1000 (-3.9A)
 1.24A 3octA-4cgnA:
undetectable		 3octA-4cgnA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4cgn GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Leishmania
major) 		4 / 5 PHE A 125
TYR A  92
LEU A 175
ARG A  89
 None
 1.20A 3sudD-4cgnA:
undetectable		 3sudD-4cgnA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 4cgn GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Leishmania
major) 		4 / 8 VAL A 308
TRP A  99
HIS A 347
PHE A  96
 None
 1.38A 3v35A-4cgnA:
undetectable		 3v35A-4cgnA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 4cgn GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Leishmania
major) 		3 / 3 LYS A 268
PRO A 269
SER A 270
 None
 0.47A 4k50I-4cgnA:
undetectable		 4k50I-4cgnA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 4cgn GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Leishmania
major) 		3 / 3 THR A 331
ASN A  91
SER A 330
 None
None
7AH  A1000 (-3.0A)
 0.77A 4tvtA-4cgnA:
undetectable		 4tvtA-4cgnA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 4cgn GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Leishmania
major) 		5 / 10 LEU A  76
LEU A  75
TYR A  80
ALA A 127
ILE A  72
 None
None
MYA  A1001 (-4.6A)
None
None
 1.16A 4xj7C-4cgnA:
undetectable
4xj7D-4cgnA:
undetectable		 4xj7C-4cgnA:
20.38
4xj7D-4cgnA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_E_SAME501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4cgn GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Leishmania
major) 		5 / 9 LEU A 222
PRO A 224
GLY A 371
SER A 221
LEU A 255
 None
 1.32A 5o96E-4cgnA:
undetectable
5o96F-4cgnA:
undetectable		 5o96E-4cgnA:
19.90
5o96F-4cgnA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_A_CYZA1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)		 4cgn GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Leishmania
major) 		5 / 10 SER A 221
ILE A 235
PRO A 236
SER A 233
GLY A 234
 None
 1.35A 5weoA-4cgnA:
undetectable
5weoD-4cgnA:
undetectable		 5weoA-4cgnA:
16.55
5weoD-4cgnA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4cgn GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Leishmania
major) 		3 / 3 LYS A 318
ASN A 315
SER A 353
 None
 1.15A 5yw0A-4cgnA:
undetectable		 5yw0A-4cgnA:
20.75