SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cgr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 4cgr PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 8 LEU A 213
ALA A 216
LEU A 143
THR A 132
 None
 0.89A 1dvtA-4cgrA:
undetectable
1dvtB-4cgrA:
undetectable		 1dvtA-4cgrA:
19.91
1dvtB-4cgrA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 4cgr PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 8 ALA A  42
LEU A  44
GLU A  32
ALA A  62
 None
 0.85A 1ie4B-4cgrA:
undetectable
1ie4D-4cgrA:
undetectable		 1ie4B-4cgrA:
23.40
1ie4D-4cgrA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 4cgr PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 10 TYR A  84
ALA A  38
ALA A  41
THR A  53
LEU A  50
 None
 1.15A 2wuzA-4cgrA:
1.2		 2wuzA-4cgrA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WV2_A_TPFA1_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4cgr PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 9 TYR A  84
ALA A  38
ALA A  41
THR A  53
LEU A  50
 None
 1.26A 2wv2A-4cgrA:
0.8		 2wv2A-4cgrA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4cgr PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 7 TYR A  84
ALA A  38
ALA A  41
THR A  53
LEU A  50
 None
 1.15A 2wx2A-4cgrA:
undetectable		 2wx2A-4cgrA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4cgr PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 TYR A  84
ALA A  38
ALA A  41
THR A  53
LEU A  50
 None
 1.09A 2x2nB-4cgrA:
undetectable		 2x2nB-4cgrA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4cgr PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 TYR A  84
ALA A  38
ALA A  41
THR A  53
LEU A  50
 None
 1.08A 2x2nC-4cgrA:
undetectable		 2x2nC-4cgrA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4cgr PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 TYR A  84
ALA A  38
ALA A  41
THR A  53
LEU A  50
 None
 1.08A 2x2nD-4cgrA:
undetectable		 2x2nD-4cgrA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_C_TPFC490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 4cgr PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 9 TYR A  84
ALA A  38
ALA A  41
THR A  53
LEU A  50
 None
 1.12A 3l4dC-4cgrA:
undetectable		 3l4dC-4cgrA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 4cgr PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		3 / 3 HIS A 114
ARG A 110
GLU A 109
 PO4  A1231 (-4.0A)
PO4  A1231 (-3.7A)
None
 1.18A 3qf1A-4cgrA:
undetectable		 3qf1A-4cgrA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)		 4cgr PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 LEU A  83
LEU A  86
GLY A  87
LEU A 116
ILE A 134
 None
 0.99A 4ok1A-4cgrA:
undetectable		 4ok1A-4cgrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4cgr PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 10 THR A 154
ALA A  94
ALA A 111
VAL A 194
GLY A  87
 None
 1.03A 4qvyK-4cgrA:
undetectable
4qvyL-4cgrA:
undetectable		 4qvyK-4cgrA:
20.98
4qvyL-4cgrA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4cgr PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 10 THR A 154
ALA A  94
ALA A 111
VAL A 194
GLY A  87
 None
 1.03A 4qvyY-4cgrA:
undetectable
4qvyZ-4cgrA:
undetectable		 4qvyY-4cgrA:
20.98
4qvyZ-4cgrA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 4cgr PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 7 ALA A 111
GLY A  87
GLU A  89
THR A 154
 None
 0.75A 4r1zB-4cgrA:
undetectable		 4r1zB-4cgrA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4cgr PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		3 / 3 ALA A 216
ASN A 219
LEU A 220
 None
 0.37A 5i1nB-4cgrA:
undetectable		 5i1nB-4cgrA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4cgr PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		3 / 3 ALA A 216
ASN A 219
LEU A 220
 None
 0.43A 5i1oA-4cgrA:
undetectable		 5i1oA-4cgrA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 4cgr PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 5 ARG A 165
PHE A 226
LEU A 183
LEU A 220
 None
 1.21A 5veuH-4cgrA:
undetectable		 5veuH-4cgrA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 4cgr PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 TYR A  84
ALA A  38
ALA A  41
THR A  53
LEU A  50
 None
 1.13A 6aybA-4cgrA:
undetectable		 6aybA-4cgrA:
18.38