SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cgs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_0
(NEURAMINIDASE)		 4cgs POLYMERASE SUBUNIT
PA
(Dhori
thogotovirus) 		5 / 12 ARG A 163
GLU A 162
GLU A  31
GLU A 166
ARG A  28
 None
 1.32A 1l7fA-4cgsA:
undetectable		 1l7fA-4cgsA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NNC_A_ZMRA479_1
(NEURAMINIDASE N9)		 4cgs POLYMERASE SUBUNIT
PA
(Dhori
thogotovirus) 		5 / 12 ARG A 163
GLU A 162
GLU A  31
GLU A 166
ARG A  28
 None
 1.21A 1nncA-4cgsA:
undetectable		 1nncA-4cgsA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 4cgs POLYMERASE SUBUNIT
PA
(Dhori
thogotovirus) 		4 / 5 GLU A 157
LEU A 161
LEU A 156
LEU A 160
 None
 0.84A 1np1A-4cgsA:
undetectable		 1np1A-4cgsA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1477_1
(NEURAMINIDASE)		 4cgs POLYMERASE SUBUNIT
PA
(Dhori
thogotovirus) 		5 / 12 ARG A 163
GLU A 162
GLU A  31
GLU A 166
ARG A  28
 None
 1.24A 2cmlA-4cgsA:
undetectable		 2cmlA-4cgsA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2477_1
(NEURAMINIDASE)		 4cgs POLYMERASE SUBUNIT
PA
(Dhori
thogotovirus) 		5 / 12 ARG A 163
GLU A 162
GLU A  31
GLU A 166
ARG A  28
 None
 1.23A 2cmlB-4cgsA:
undetectable		 2cmlB-4cgsA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3477_1
(NEURAMINIDASE)		 4cgs POLYMERASE SUBUNIT
PA
(Dhori
thogotovirus) 		5 / 12 ARG A 163
GLU A 162
GLU A  31
GLU A 166
ARG A  28
 None
 1.23A 2cmlC-4cgsA:
undetectable		 2cmlC-4cgsA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4477_1
(NEURAMINIDASE)		 4cgs POLYMERASE SUBUNIT
PA
(Dhori
thogotovirus) 		5 / 12 ARG A 163
GLU A 162
GLU A  31
GLU A 166
ARG A  28
 None
 1.19A 2cmlD-4cgsA:
undetectable		 2cmlD-4cgsA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4cgs POLYMERASE SUBUNIT
PA
(Dhori
thogotovirus) 		6 / 12 ILE A   9
PHE A 147
HIS A  45
CYH A  43
ILE A  38
MET A  62
 None
None
CME  A  44 ( 4.9A)
CME  A  44 ( 4.8A)
None
None
 1.37A 2xkwB-4cgsA:
undetectable		 2xkwB-4cgsA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 4cgs POLYMERASE SUBUNIT
PA
(Dhori
thogotovirus) 		4 / 7 VAL A 120
ARG A 121
GLY A 126
VAL A 144
 None
 0.83A 2y05A-4cgsA:
undetectable
2y05B-4cgsA:
undetectable		 2y05A-4cgsA:
21.23
2y05B-4cgsA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7E_A_ZMRA1001_1
(NEURAMINIDASE)		 4cgs POLYMERASE SUBUNIT
PA
(Dhori
thogotovirus) 		5 / 12 ARG A 163
GLU A 162
GLU A  31
GLU A 166
ARG A  28
 None
 1.21A 3b7eA-4cgsA:
undetectable		 3b7eA-4cgsA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7E_B_ZMRB1002_1
(NEURAMINIDASE)		 4cgs POLYMERASE SUBUNIT
PA
(Dhori
thogotovirus) 		5 / 12 ARG A 163
GLU A 162
GLU A  31
GLU A 166
ARG A  28
 None
 1.22A 3b7eB-4cgsA:
undetectable		 3b7eB-4cgsA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 4cgs POLYMERASE SUBUNIT
PA
(Dhori
thogotovirus) 		5 / 7 VAL A  42
THR A  41
ILE A  38
ILE A 151
SER A   8
 None
 1.07A 3deuA-4cgsA:
undetectable		 3deuA-4cgsA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_0
(NEURAMINIDASE)		 4cgs POLYMERASE SUBUNIT
PA
(Dhori
thogotovirus) 		5 / 12 ARG A 163
GLU A 162
GLU A  31
GLU A 166
ARG A  28
 None
 1.26A 3k37A-4cgsA:
undetectable		 3k37A-4cgsA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_A_ZMRA901_1
(NEURAMINIDASE)		 4cgs POLYMERASE SUBUNIT
PA
(Dhori
thogotovirus) 		5 / 12 ARG A 163
GLU A 162
GLU A  31
GLU A 166
ARG A  28
 None
 1.24A 3sanA-4cgsA:
undetectable		 3sanA-4cgsA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_B_ZMRB901_1
(NEURAMINIDASE)		 4cgs POLYMERASE SUBUNIT
PA
(Dhori
thogotovirus) 		5 / 12 ARG A 163
GLU A 162
GLU A  31
GLU A 166
ARG A  28
 None
 1.25A 3sanB-4cgsA:
undetectable		 3sanB-4cgsA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI5_A_ZMRA1002_1
(NEURAMINIDASE)		 4cgs POLYMERASE SUBUNIT
PA
(Dhori
thogotovirus) 		5 / 12 ARG A 163
GLU A 162
GLU A  31
GLU A 166
ARG A  28
 None
 1.22A 3ti5A-4cgsA:
undetectable		 3ti5A-4cgsA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI5_B_ZMRB1002_1
(NEURAMINIDASE)		 4cgs POLYMERASE SUBUNIT
PA
(Dhori
thogotovirus) 		5 / 12 ARG A 163
GLU A 162
GLU A  31
GLU A 166
ARG A  28
 None
 1.21A 3ti5B-4cgsA:
undetectable		 3ti5B-4cgsA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_B_ZMRB1002_1
(NEURAMINIDASE)		 4cgs POLYMERASE SUBUNIT
PA
(Dhori
thogotovirus) 		5 / 12 ARG A 163
GLU A 162
GLU A  31
GLU A 166
ARG A  28
 None
 1.22A 3ticB-4cgsA:
undetectable		 3ticB-4cgsA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_C_ZMRC1002_1
(NEURAMINIDASE)		 4cgs POLYMERASE SUBUNIT
PA
(Dhori
thogotovirus) 		5 / 12 ARG A 163
GLU A 162
GLU A  31
GLU A 166
ARG A  28
 None
 1.25A 3ticC-4cgsA:
undetectable		 3ticC-4cgsA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_D_ZMRD1002_1
(NEURAMINIDASE)		 4cgs POLYMERASE SUBUNIT
PA
(Dhori
thogotovirus) 		5 / 12 ARG A 163
GLU A 162
GLU A  31
GLU A 166
ARG A  28
 None
 1.24A 3ticD-4cgsA:
undetectable		 3ticD-4cgsA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4cgs POLYMERASE SUBUNIT
PA
(Dhori
thogotovirus) 		5 / 12 PRO A   6
LEU A 160
LEU A 124
ILE A 151
ILE A  34
 None
 1.26A 4a79B-4cgsA:
undetectable		 4a79B-4cgsA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_1
(NEURAMINIDASE)		 4cgs POLYMERASE SUBUNIT
PA
(Dhori
thogotovirus) 		5 / 12 ARG A 163
GLU A 162
GLU A  31
GLU A 166
ARG A  28
 None
 1.23A 4b7nA-4cgsA:
undetectable		 4b7nA-4cgsA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_1
(NEURAMINIDASE)		 4cgs POLYMERASE SUBUNIT
PA
(Dhori
thogotovirus) 		5 / 12 ARG A 163
GLU A 162
GLU A  31
GLU A 166
ARG A  28
 None
 1.27A 4b7qA-4cgsA:
undetectable		 4b7qA-4cgsA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_B_ZMRB601_1
(NEURAMINIDASE)		 4cgs POLYMERASE SUBUNIT
PA
(Dhori
thogotovirus) 		5 / 12 ARG A 163
GLU A 162
GLU A  31
GLU A 166
ARG A  28
 None
 1.20A 4b7qB-4cgsA:
undetectable		 4b7qB-4cgsA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_D_ZMRD601_1
(NEURAMINIDASE)		 4cgs POLYMERASE SUBUNIT
PA
(Dhori
thogotovirus) 		5 / 12 ARG A 163
GLU A 162
GLU A  31
GLU A 166
ARG A  28
 None
 1.23A 4b7qD-4cgsA:
undetectable		 4b7qD-4cgsA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B402_1
(PROTEASE)		 4cgs POLYMERASE SUBUNIT
PA
(Dhori
thogotovirus) 		4 / 5 TRP A  23
PRO A  29
ARG A  33
PRO A   6
 None
 1.39A 4j5jB-4cgsA:
0.0		 4j5jB-4cgsA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_1
(NEURAMINIDASE)		 4cgs POLYMERASE SUBUNIT
PA
(Dhori
thogotovirus) 		5 / 12 ARG A 163
GLU A 162
GLU A  31
GLU A 166
ARG A  28
 None
 1.23A 4mwrA-4cgsA:
undetectable		 4mwrA-4cgsA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L17_A_ZMRA512_1
(NEURAMINIDASE)		 4cgs POLYMERASE SUBUNIT
PA
(Dhori
thogotovirus) 		5 / 12 ARG A 163
GLU A 162
GLU A  31
GLU A 166
ARG A  28
 None
 1.26A 5l17A-4cgsA:
undetectable		 5l17A-4cgsA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4cgs POLYMERASE SUBUNIT
PA
(Dhori
thogotovirus) 		3 / 3 CYH A  43
MET A  62
ASN A  61
 CME  A  44 ( 4.8A)
None
None
 0.87A 5qh8A-4cgsA:
undetectable		 5qh8A-4cgsA:
21.53