SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cgy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		3 / 3 ASP A 429
THR A 347
GLU A 520
 None
 0.87A 1pj7A-4cgyA:
undetectable		 1pj7A-4cgyA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 8 TYR A 634
GLY A 562
GLY A 565
GLY A 567
LEU A 564
 None
 1.31A 1qzzA-4cgyA:
undetectable		 1qzzA-4cgyA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_B_CHDB4085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE II
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 11 MET A 566
GLY A 565
THR A 544
PHE A 559
GLY A 552
 None
 1.43A 1v54A-4cgyA:
1.6
1v54B-4cgyA:
undetectable
1v54T-4cgyA:
undetectable		 1v54A-4cgyA:
20.21
1v54B-4cgyA:
12.96
1v54T-4cgyA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_O_CHDO3085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE II
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 11 PHE A 559
GLY A 552
MET A 566
GLY A 565
THR A 544
 None
 1.36A 1v54G-4cgyA:
undetectable
1v54N-4cgyA:
1.6
1v54O-4cgyA:
undetectable		 1v54G-4cgyA:
9.36
1v54N-4cgyA:
20.21
1v54O-4cgyA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_O_CHDO3085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE II
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 11 PHE A 559
GLY A 552
MET A 566
GLY A 565
THR A 544
 None
 1.36A 1v55G-4cgyA:
undetectable
1v55N-4cgyA:
1.7
1v55O-4cgyA:
undetectable		 1v55G-4cgyA:
9.36
1v55N-4cgyA:
20.21
1v55O-4cgyA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		4 / 5 PHE A 221
LEU A 226
MET A 575
SER A 574
 None
 1.20A 1wrlC-4cgyA:
undetectable		 1wrlC-4cgyA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XQL_A_4AXA605_1
(ALANINE RACEMASE)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		4 / 8 PHE A 178
TYR A 362
CYH A 149
ARG A 175
 None
 1.42A 1xqlA-4cgyA:
undetectable
1xqlB-4cgyA:
undetectable		 1xqlA-4cgyA:
21.03
1xqlB-4cgyA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XQL_B_4AXB505_1
(ALANINE RACEMASE)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		4 / 8 ARG A 175
PHE A 178
TYR A 362
CYH A 149
 None
 1.41A 1xqlA-4cgyA:
undetectable
1xqlB-4cgyA:
undetectable		 1xqlA-4cgyA:
21.03
1xqlB-4cgyA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 12 GLY A 390
LEU A 478
ASP A 479
ASP A 484
SER A 446
 None
 1.25A 2b9eA-4cgyA:
undetectable		 2b9eA-4cgyA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_O_CHDO229_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 11 PHE A 559
GLY A 552
MET A 566
GLY A 565
THR A 544
 None
 1.37A 2dyrG-4cgyA:
undetectable
2dyrN-4cgyA:
1.7
2dyrO-4cgyA:
undetectable		 2dyrG-4cgyA:
9.36
2dyrN-4cgyA:
20.21
2dyrO-4cgyA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_O_CHDO229_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 11 PHE A 559
GLY A 552
MET A 566
GLY A 565
THR A 544
 None
 1.37A 2eijG-4cgyA:
undetectable
2eijN-4cgyA:
1.7
2eijO-4cgyA:
undetectable		 2eijG-4cgyA:
9.36
2eijN-4cgyA:
20.21
2eijO-4cgyA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_O_CHDO229_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 11 PHE A 559
GLY A 552
MET A 566
GLY A 565
THR A 544
 None
 1.38A 2eikG-4cgyA:
undetectable
2eikN-4cgyA:
1.8
2eikO-4cgyA:
undetectable		 2eikG-4cgyA:
9.36
2eikN-4cgyA:
20.21
2eikO-4cgyA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_O_CHDO229_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 11 PHE A 559
GLY A 552
MET A 566
GLY A 565
THR A 544
 None
 1.39A 2eilG-4cgyA:
undetectable
2eilN-4cgyA:
1.8
2eilO-4cgyA:
undetectable		 2eilG-4cgyA:
9.36
2eilN-4cgyA:
20.21
2eilO-4cgyA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_N_CHDN1604_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 11 PHE A 559
GLY A 552
MET A 566
GLY A 565
THR A 544
 None
 1.38A 2eimG-4cgyA:
undetectable
2eimN-4cgyA:
2.2
2eimO-4cgyA:
undetectable		 2eimG-4cgyA:
9.36
2eimN-4cgyA:
20.21
2eimO-4cgyA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		4 / 8 TYR A 241
PHE A 246
VAL A 551
TYR A 550
 None
 1.17A 2fl5E-4cgyA:
undetectable
2fl5F-4cgyA:
undetectable		 2fl5E-4cgyA:
15.17
2fl5F-4cgyA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 11 ILE A 145
GLY A  91
LEU A 133
GLY A 157
GLU A 159
 None
 1.32A 2fn1A-4cgyA:
undetectable		 2fn1A-4cgyA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		4 / 8 TYR A 241
SER A 240
THR A 219
LEU A 113
 None
 0.93A 2v0zO-4cgyA:
undetectable		 2v0zO-4cgyA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		6 / 12 MET A  84
PHE A  73
TYR A  75
VAL A  33
ALA A  50
LEU A 193
 None
 1.40A 2x2nC-4cgyA:
undetectable		 2x2nC-4cgyA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_G_CHDG1085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 6A2
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 10 PHE A 559
GLY A 552
MET A 566
GLY A 565
THR A 544
 None
 1.39A 2y69G-4cgyA:
undetectable
2y69N-4cgyA:
0.0
2y69O-4cgyA:
undetectable		 2y69G-4cgyA:
10.27
2y69N-4cgyA:
20.21
2y69O-4cgyA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_T_CHDT1085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 6A2
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 10 MET A 566
GLY A 565
THR A 544
PHE A 559
GLY A 552
 None
 1.41A 2y69A-4cgyA:
0.0
2y69B-4cgyA:
0.0
2y69T-4cgyA:
0.0		 2y69A-4cgyA:
20.21
2y69B-4cgyA:
12.96
2y69T-4cgyA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 10 THR A 182
GLY A 358
THR A 420
HIS A 418
PRO A 415
 None
 1.35A 2y7wB-4cgyA:
undetectable		 2y7wB-4cgyA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_B_CHDB1086_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 6A2
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 11 MET A 566
GLY A 565
THR A 544
PHE A 559
GLY A 552
 None
 1.44A 2zxwA-4cgyA:
1.8
2zxwB-4cgyA:
undetectable
2zxwT-4cgyA:
undetectable		 2zxwA-4cgyA:
20.21
2zxwB-4cgyA:
12.96
2zxwT-4cgyA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_G_CHDG86_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 6A2
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 11 PHE A 559
GLY A 552
MET A 566
GLY A 565
THR A 544
 None
 1.41A 2zxwG-4cgyA:
undetectable
2zxwN-4cgyA:
3.6
2zxwO-4cgyA:
undetectable		 2zxwG-4cgyA:
9.36
2zxwN-4cgyA:
20.21
2zxwO-4cgyA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 11 MET A 566
GLY A 565
THR A 544
PHE A 559
GLY A 552
 None
 1.41A 3abkA-4cgyA:
1.9
3abkB-4cgyA:
undetectable
3abkT-4cgyA:
undetectable		 3abkA-4cgyA:
20.21
3abkB-4cgyA:
12.96
3abkT-4cgyA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 10 PHE A 559
GLY A 552
MET A 566
GLY A 565
THR A 544
 None
 1.38A 3abkG-4cgyA:
undetectable
3abkN-4cgyA:
0.0
3abkO-4cgyA:
undetectable		 3abkG-4cgyA:
9.36
3abkN-4cgyA:
20.21
3abkO-4cgyA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_B_CHDB1086_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 11 MET A 566
GLY A 565
THR A 544
PHE A 559
GLY A 552
 None
 1.45A 3ablA-4cgyA:
1.8
3ablB-4cgyA:
undetectable
3ablT-4cgyA:
undetectable		 3ablA-4cgyA:
20.21
3ablB-4cgyA:
12.96
3ablT-4cgyA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 10 PHE A 559
GLY A 552
MET A 566
GLY A 565
THR A 544
 None
 1.38A 3ablG-4cgyA:
undetectable
3ablN-4cgyA:
1.6
3ablO-4cgyA:
undetectable		 3ablG-4cgyA:
9.36
3ablN-4cgyA:
20.21
3ablO-4cgyA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_B_CHDB1086_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 11 MET A 566
GLY A 565
THR A 544
PHE A 559
GLY A 552
 None
 1.43A 3abmA-4cgyA:
1.6
3abmB-4cgyA:
undetectable
3abmT-4cgyA:
undetectable		 3abmA-4cgyA:
20.21
3abmB-4cgyA:
12.96
3abmT-4cgyA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 10 PHE A 559
GLY A 552
MET A 566
GLY A 565
THR A 544
 None
 1.39A 3abmG-4cgyA:
undetectable
3abmN-4cgyA:
0.0
3abmO-4cgyA:
undetectable		 3abmG-4cgyA:
9.36
3abmN-4cgyA:
20.21
3abmO-4cgyA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 11 MET A 566
GLY A 565
THR A 544
PHE A 559
GLY A 552
 None
 1.45A 3ag1A-4cgyA:
2.0
3ag1B-4cgyA:
undetectable
3ag1T-4cgyA:
undetectable		 3ag1A-4cgyA:
20.21
3ag1B-4cgyA:
12.96
3ag1T-4cgyA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_G_CHDG86_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 10 PHE A 559
GLY A 552
MET A 566
GLY A 565
THR A 544
 None
 1.36A 3ag2G-4cgyA:
undetectable
3ag2N-4cgyA:
1.1
3ag2O-4cgyA:
undetectable		 3ag2G-4cgyA:
9.36
3ag2N-4cgyA:
20.21
3ag2O-4cgyA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 11 MET A 566
GLY A 565
THR A 544
PHE A 559
GLY A 552
 None
 1.39A 3ag3A-4cgyA:
2.1
3ag3B-4cgyA:
undetectable
3ag3T-4cgyA:
undetectable		 3ag3A-4cgyA:
20.21
3ag3B-4cgyA:
12.96
3ag3T-4cgyA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 11 PHE A 559
GLY A 552
MET A 566
GLY A 565
THR A 544
 None
 1.37A 3ag3G-4cgyA:
undetectable
3ag3N-4cgyA:
1.8
3ag3O-4cgyA:
undetectable		 3ag3G-4cgyA:
9.36
3ag3N-4cgyA:
20.21
3ag3O-4cgyA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 12 MET A 566
GLY A 565
THR A 544
PHE A 559
GLY A 552
 None
 1.49A 3ag4A-4cgyA:
1.6
3ag4B-4cgyA:
undetectable
3ag4T-4cgyA:
undetectable		 3ag4A-4cgyA:
20.21
3ag4B-4cgyA:
12.96
3ag4T-4cgyA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 10 PHE A 559
GLY A 552
MET A 566
GLY A 565
THR A 544
 None
 1.42A 3ag4G-4cgyA:
undetectable
3ag4N-4cgyA:
1.8
3ag4O-4cgyA:
undetectable		 3ag4G-4cgyA:
9.36
3ag4N-4cgyA:
20.21
3ag4O-4cgyA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 11 MET A 566
GLY A 565
THR A 544
PHE A 559
GLY A 552
 None
 1.39A 3asnA-4cgyA:
1.5
3asnB-4cgyA:
undetectable
3asnT-4cgyA:
undetectable		 3asnA-4cgyA:
20.21
3asnB-4cgyA:
12.96
3asnT-4cgyA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_G_CHDG229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 10 PHE A 559
GLY A 552
MET A 566
GLY A 565
THR A 544
 None
 1.35A 3asnG-4cgyA:
undetectable
3asnN-4cgyA:
0.2
3asnO-4cgyA:
undetectable		 3asnG-4cgyA:
9.36
3asnN-4cgyA:
20.21
3asnO-4cgyA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 11 MET A 566
GLY A 565
THR A 544
PHE A 559
GLY A 552
 None
 1.40A 3asoA-4cgyA:
1.6
3asoB-4cgyA:
undetectable
3asoT-4cgyA:
undetectable		 3asoA-4cgyA:
20.21
3asoB-4cgyA:
12.96
3asoT-4cgyA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_G_CHDG229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 10 PHE A 559
GLY A 552
MET A 566
GLY A 565
THR A 544
 None
 1.34A 3asoG-4cgyA:
undetectable
3asoN-4cgyA:
0.0
3asoO-4cgyA:
undetectable		 3asoG-4cgyA:
9.36
3asoN-4cgyA:
20.21
3asoO-4cgyA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		4 / 5 VAL A 252
VAL A 253
THR A 554
THR A 248
 None
 1.04A 3bjwA-4cgyA:
undetectable		 3bjwA-4cgyA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		4 / 5 VAL A 252
VAL A 253
THR A 554
THR A 248
 None
 1.05A 3bjwG-4cgyA:
1.0		 3bjwG-4cgyA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_1
(PHOSPHOLIPASE A2)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		4 / 5 VAL A 252
VAL A 253
THR A 554
THR A 248
 None
 1.04A 3bjwC-4cgyA:
undetectable		 3bjwC-4cgyA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		4 / 5 VAL A 252
VAL A 253
THR A 554
THR A 248
 None
 1.02A 3bjwD-4cgyA:
undetectable		 3bjwD-4cgyA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		3 / 3 MET A 575
VAL A 616
GLU A 578
 None
 0.90A 3c6gA-4cgyA:
undetectable		 3c6gA-4cgyA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_1
(YAEB-LIKE PROTEIN
RPA0152)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		4 / 5 SER A 361
ARG A 177
ASP A 411
THR A 329
 None
 1.47A 3okxA-4cgyA:
undetectable		 3okxA-4cgyA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_2
(YAEB-LIKE PROTEIN
RPA0152)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		4 / 5 SER A 361
ARG A 177
ASP A 411
THR A 329
 None
 1.45A 3okxB-4cgyA:
undetectable		 3okxB-4cgyA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		4 / 6 GLN A 382
PHE A 441
PRO A 419
LEU A 442
 None
 1.42A 3tgvB-4cgyA:
undetectable		 3tgvB-4cgyA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 11 MET A 566
GLY A 565
THR A 544
PHE A 559
GLY A 552
 None
 1.42A 3wg7A-4cgyA:
1.9
3wg7B-4cgyA:
undetectable
3wg7T-4cgyA:
undetectable		 3wg7A-4cgyA:
20.21
3wg7B-4cgyA:
12.96
3wg7T-4cgyA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_G_CHDG103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 10 PHE A 559
GLY A 552
MET A 566
GLY A 565
THR A 544
 None
 1.36A 3wg7G-4cgyA:
undetectable
3wg7N-4cgyA:
1.6
3wg7O-4cgyA:
undetectable		 3wg7G-4cgyA:
9.36
3wg7N-4cgyA:
20.21
3wg7O-4cgyA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 11 MET A 566
GLY A 565
THR A 544
PHE A 559
GLY A 552
 None
 1.47A 3x2qA-4cgyA:
2.0
3x2qB-4cgyA:
undetectable
3x2qT-4cgyA:
undetectable		 3x2qA-4cgyA:
20.21
3x2qB-4cgyA:
12.96
3x2qT-4cgyA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_O_CHDO302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 10 PHE A 559
GLY A 552
MET A 566
GLY A 565
THR A 544
 None
 1.38A 3x2qG-4cgyA:
undetectable
3x2qN-4cgyA:
0.5
3x2qO-4cgyA:
undetectable		 3x2qG-4cgyA:
9.36
3x2qN-4cgyA:
20.21
3x2qO-4cgyA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		4 / 6 GLY A 157
ASP A 150
HIS A 414
ARG A 175
 None
MG  A1640 ( 4.2A)
None
None
 1.24A 4lajA-4cgyA:
undetectable
4lajB-4cgyA:
undetectable		 4lajA-4cgyA:
19.56
4lajB-4cgyA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		4 / 5 LEU A 553
GLY A 552
ILE A 542
LYS A 345
 None
 1.09A 4ma8C-4cgyA:
undetectable		 4ma8C-4cgyA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		4 / 5 THR A 423
LEU A 426
THR A 347
MET A 348
 None
 1.29A 4mbsB-4cgyA:
undetectable		 4mbsB-4cgyA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		4 / 5 ILE A  70
ASP A 128
GLU A 136
VAL A  39
 None
 1.04A 4nkxC-4cgyA:
undetectable		 4nkxC-4cgyA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		4 / 5 ILE A  70
ASP A 128
GLU A 136
VAL A  39
 None
 1.07A 4nkxD-4cgyA:
undetectable		 4nkxD-4cgyA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 11 MET A 566
GLY A 565
THR A 544
PHE A 559
GLY A 552
 None
 1.37A 5b1aA-4cgyA:
1.8
5b1aB-4cgyA:
undetectable
5b1aT-4cgyA:
undetectable		 5b1aA-4cgyA:
20.21
5b1aB-4cgyA:
12.96
5b1aT-4cgyA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_O_CHDO302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 10 PHE A 559
GLY A 552
MET A 566
GLY A 565
THR A 544
 None
 1.36A 5b1aG-4cgyA:
undetectable
5b1aN-4cgyA:
0.0
5b1aO-4cgyA:
undetectable		 5b1aG-4cgyA:
9.36
5b1aN-4cgyA:
20.21
5b1aO-4cgyA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 11 MET A 566
GLY A 565
THR A 544
PHE A 559
GLY A 552
 None
 1.41A 5b1bA-4cgyA:
undetectable
5b1bB-4cgyA:
undetectable
5b1bT-4cgyA:
undetectable		 5b1bA-4cgyA:
20.21
5b1bB-4cgyA:
12.96
5b1bT-4cgyA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_G_CHDG103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 11 PHE A 559
GLY A 552
MET A 566
GLY A 565
THR A 544
 None
 1.36A 5b1bG-4cgyA:
undetectable
5b1bN-4cgyA:
1.6
5b1bO-4cgyA:
undetectable		 5b1bG-4cgyA:
9.36
5b1bN-4cgyA:
20.21
5b1bO-4cgyA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 11 MET A 566
GLY A 565
THR A 544
PHE A 559
GLY A 552
 None
 1.37A 5b3sA-4cgyA:
1.5
5b3sB-4cgyA:
undetectable
5b3sT-4cgyA:
undetectable		 5b3sA-4cgyA:
20.21
5b3sB-4cgyA:
12.96
5b3sT-4cgyA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_G_CHDG102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 10 PHE A 559
GLY A 552
MET A 566
GLY A 565
THR A 544
 None
 1.35A 5b3sG-4cgyA:
0.0
5b3sN-4cgyA:
0.0
5b3sO-4cgyA:
0.0		 5b3sG-4cgyA:
9.36
5b3sN-4cgyA:
20.21
5b3sO-4cgyA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_G_CHDG102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 10 PHE A 559
GLY A 552
MET A 566
GLY A 565
THR A 544
 None
 1.45A 5iy5G-4cgyA:
0.0
5iy5N-4cgyA:
0.0
5iy5O-4cgyA:
0.0		 5iy5G-4cgyA:
7.14
5iy5N-4cgyA:
20.21
5iy5O-4cgyA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_T_CHDT103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 10 MET A 566
GLY A 565
THR A 544
PHE A 559
GLY A 552
 None
 1.48A 5iy5A-4cgyA:
1.8
5iy5B-4cgyA:
undetectable
5iy5T-4cgyA:
undetectable		 5iy5A-4cgyA:
20.21
5iy5B-4cgyA:
12.96
5iy5T-4cgyA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 12 ALA A 525
ILE A 532
GLY A 531
LEU A 523
LEU A 518
 None
 0.76A 5nfjB-4cgyA:
undetectable		 5nfjB-4cgyA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 12 ALA A 525
ILE A 532
GLY A 531
LEU A 523
LEU A 518
 None
 0.76A 5nfjC-4cgyA:
undetectable		 5nfjC-4cgyA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		4 / 8 ALA A 344
ILE A 350
ALA A 351
LEU A 433
 None
 0.81A 5te8B-4cgyA:
undetectable		 5te8B-4cgyA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHG_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 12 LEU A 560
ASP A 522
ARG A 255
PRO A 514
ILE A 259
 None
 1.43A 5uhgC-4cgyA:
3.2		 5uhgC-4cgyA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 11 PHE A 559
GLY A 552
MET A 566
GLY A 565
THR A 544
 None
 1.45A 5w97G-4cgyA:
undetectable
5w97a-4cgyA:
1.4
5w97b-4cgyA:
undetectable		 5w97G-4cgyA:
9.36
5w97a-4cgyA:
20.21
5w97b-4cgyA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 11 MET A 566
GLY A 565
THR A 544
PHE A 559
GLY A 552
 None
 1.45A 5w97A-4cgyA:
1.4
5w97B-4cgyA:
undetectable
5w97g-4cgyA:
undetectable		 5w97A-4cgyA:
20.21
5w97B-4cgyA:
12.96
5w97g-4cgyA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 10 MET A 566
GLY A 565
THR A 544
PHE A 559
GLY A 552
 None
 1.41A 5wauA-4cgyA:
2.1
5wauB-4cgyA:
undetectable
5waug-4cgyA:
undetectable		 5wauA-4cgyA:
20.21
5wauB-4cgyA:
12.96
5waug-4cgyA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_G_CHDG103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 10 PHE A 559
GLY A 552
MET A 566
GLY A 565
THR A 544
 None
 1.40A 5wauG-4cgyA:
undetectable
5waua-4cgyA:
0.0
5waub-4cgyA:
undetectable		 5wauG-4cgyA:
9.36
5waua-4cgyA:
20.21
5waub-4cgyA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 11 MET A 566
GLY A 565
THR A 544
PHE A 559
GLY A 552
 None
 1.36A 5x19A-4cgyA:
1.5
5x19B-4cgyA:
undetectable
5x19T-4cgyA:
undetectable		 5x19A-4cgyA:
20.21
5x19B-4cgyA:
12.96
5x19T-4cgyA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_G_CHDG104_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 11 PHE A 559
GLY A 552
MET A 566
GLY A 565
THR A 544
 None
 1.38A 5x19G-4cgyA:
undetectable
5x19N-4cgyA:
0.0
5x19O-4cgyA:
undetectable		 5x19G-4cgyA:
9.36
5x19N-4cgyA:
20.21
5x19O-4cgyA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 10 MET A 566
GLY A 565
THR A 544
PHE A 559
GLY A 552
 None
 1.40A 5x1bA-4cgyA:
0.4
5x1bB-4cgyA:
undetectable
5x1bT-4cgyA:
undetectable		 5x1bA-4cgyA:
20.21
5x1bB-4cgyA:
12.96
5x1bT-4cgyA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_O_CHDO302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 11 PHE A 559
GLY A 552
MET A 566
GLY A 565
THR A 544
 None
 1.37A 5x1bG-4cgyA:
undetectable
5x1bN-4cgyA:
1.7
5x1bO-4cgyA:
undetectable		 5x1bG-4cgyA:
9.36
5x1bN-4cgyA:
20.21
5x1bO-4cgyA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 10 MET A 566
GLY A 565
THR A 544
PHE A 559
GLY A 552
 None
 1.39A 5x1fA-4cgyA:
1.7
5x1fB-4cgyA:
0.0
5x1fT-4cgyA:
0.0		 5x1fA-4cgyA:
20.21
5x1fB-4cgyA:
12.96
5x1fT-4cgyA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_G_CHDG104_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 11 PHE A 559
GLY A 552
MET A 566
GLY A 565
THR A 544
 None
 1.37A 5x1fG-4cgyA:
undetectable
5x1fN-4cgyA:
1.6
5x1fO-4cgyA:
undetectable		 5x1fG-4cgyA:
9.36
5x1fN-4cgyA:
20.21
5x1fO-4cgyA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 11 MET A 566
GLY A 565
THR A 544
PHE A 559
GLY A 552
 None
 1.42A 5xdqA-4cgyA:
1.8
5xdqB-4cgyA:
undetectable
5xdqT-4cgyA:
undetectable		 5xdqA-4cgyA:
20.21
5xdqB-4cgyA:
12.96
5xdqT-4cgyA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_G_CHDG102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 10 PHE A 559
GLY A 552
MET A 566
GLY A 565
THR A 544
 None
 1.40A 5xdqG-4cgyA:
undetectable
5xdqN-4cgyA:
0.0
5xdqO-4cgyA:
undetectable		 5xdqG-4cgyA:
9.36
5xdqN-4cgyA:
20.21
5xdqO-4cgyA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 11 MET A 566
GLY A 565
THR A 544
PHE A 559
GLY A 552
 None
 1.45A 5xdxA-4cgyA:
1.6
5xdxB-4cgyA:
undetectable
5xdxT-4cgyA:
undetectable		 5xdxA-4cgyA:
20.21
5xdxB-4cgyA:
12.96
5xdxT-4cgyA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_O_CHDO301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 10 PHE A 559
GLY A 552
MET A 566
GLY A 565
THR A 544
 None
 1.41A 5xdxG-4cgyA:
undetectable
5xdxN-4cgyA:
0.0
5xdxO-4cgyA:
undetectable		 5xdxG-4cgyA:
9.36
5xdxN-4cgyA:
20.21
5xdxO-4cgyA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 11 MET A 566
GLY A 565
THR A 544
PHE A 559
GLY A 552
 None
 1.46A 5z84A-4cgyA:
1.5
5z84B-4cgyA:
undetectable
5z84T-4cgyA:
undetectable		 5z84A-4cgyA:
20.21
5z84B-4cgyA:
12.96
5z84T-4cgyA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_G_CHDG101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 10 PHE A 559
GLY A 552
MET A 566
GLY A 565
THR A 544
 None
 1.41A 5z84G-4cgyA:
undetectable
5z84N-4cgyA:
1.7
5z84O-4cgyA:
undetectable		 5z84G-4cgyA:
9.36
5z84N-4cgyA:
20.21
5z84O-4cgyA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_G_CHDG103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 10 PHE A 559
GLY A 552
MET A 566
GLY A 565
THR A 544
 None
 1.39A 5z85G-4cgyA:
undetectable
5z85N-4cgyA:
0.0
5z85O-4cgyA:
undetectable		 5z85G-4cgyA:
9.36
5z85N-4cgyA:
20.21
5z85O-4cgyA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_T_CHDT101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 10 MET A 566
GLY A 565
THR A 544
PHE A 559
GLY A 552
 None
 1.46A 5z85A-4cgyA:
0.0
5z85B-4cgyA:
undetectable
5z85T-4cgyA:
undetectable		 5z85A-4cgyA:
20.21
5z85B-4cgyA:
12.96
5z85T-4cgyA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 11 MET A 566
GLY A 565
THR A 544
PHE A 559
GLY A 552
 None
 1.44A 5z86A-4cgyA:
1.8
5z86B-4cgyA:
undetectable
5z86T-4cgyA:
undetectable		 5z86A-4cgyA:
20.21
5z86B-4cgyA:
12.96
5z86T-4cgyA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_G_CHDG103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 10 PHE A 559
GLY A 552
MET A 566
GLY A 565
THR A 544
 None
 1.40A 5z86G-4cgyA:
undetectable
5z86N-4cgyA:
0.5
5z86O-4cgyA:
undetectable		 5z86G-4cgyA:
9.36
5z86N-4cgyA:
20.21
5z86O-4cgyA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 11 MET A 566
GLY A 565
THR A 544
PHE A 559
GLY A 552
 None
 1.42A 5zcoA-4cgyA:
1.8
5zcoB-4cgyA:
undetectable
5zcoT-4cgyA:
undetectable		 5zcoA-4cgyA:
20.21
5zcoB-4cgyA:
12.96
5zcoT-4cgyA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_G_CHDG102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 10 PHE A 559
GLY A 552
MET A 566
GLY A 565
THR A 544
 None
 1.38A 5zcoG-4cgyA:
undetectable
5zcoN-4cgyA:
0.0
5zcoO-4cgyA:
undetectable		 5zcoG-4cgyA:
9.36
5zcoN-4cgyA:
20.21
5zcoO-4cgyA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 11 MET A 566
GLY A 565
THR A 544
PHE A 559
GLY A 552
 None
 1.45A 5zcpA-4cgyA:
1.8
5zcpB-4cgyA:
undetectable
5zcpT-4cgyA:
undetectable		 5zcpA-4cgyA:
20.21
5zcpB-4cgyA:
12.96
5zcpT-4cgyA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_G_CHDG102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 10 PHE A 559
GLY A 552
MET A 566
GLY A 565
THR A 544
 None
 1.38A 5zcpG-4cgyA:
0.0
5zcpN-4cgyA:
0.5
5zcpO-4cgyA:
0.0		 5zcpG-4cgyA:
9.36
5zcpN-4cgyA:
20.21
5zcpO-4cgyA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 11 MET A 566
GLY A 565
THR A 544
PHE A 559
GLY A 552
 None
 1.42A 5zcqA-4cgyA:
1.8
5zcqB-4cgyA:
undetectable
5zcqT-4cgyA:
undetectable		 5zcqA-4cgyA:
20.21
5zcqB-4cgyA:
12.96
5zcqT-4cgyA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_G_CHDG103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 10 PHE A 559
GLY A 552
MET A 566
GLY A 565
THR A 544
 None
 1.39A 5zcqG-4cgyA:
0.0
5zcqN-4cgyA:
0.0
5zcqO-4cgyA:
0.0		 5zcqG-4cgyA:
9.36
5zcqN-4cgyA:
20.21
5zcqO-4cgyA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AY4_A_TPFA506_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 10 MET A  84
PHE A  73
TYR A  75
ALA A  50
LEU A 193
 None
 1.50A 6ay4A-4cgyA:
undetectable		 6ay4A-4cgyA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		4 / 6 ASP A 150
ARG A 364
GLU A 352
GLU A 540
 MG  A1640 ( 4.2A)
None
MG  A1640 ( 4.3A)
None
 1.44A 6mn5D-4cgyA:
undetectable		 6mn5D-4cgyA:
7.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens) 		5 / 11 MET A 566
GLY A 565
THR A 544
PHE A 559
GLY A 552
 None
 1.44A 6nknA-4cgyA:
0.3
6nknB-4cgyA:
undetectable
6nknT-4cgyA:
undetectable		 6nknA-4cgyA:
20.21
6nknB-4cgyA:
12.96
6nknT-4cgyA:
9.36