SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ch1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 4ch1 PROTEIN SUP-12,
ISOFORM B
(Caenorhabditis
elegans) 		4 / 8 GLY A  77
THR A  68
GLY A  79
ASP A  48
 None
 0.85A 1aegA-4ch1A:
undetectable		 1aegA-4ch1A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_3
(HIV-1 PROTEASE)		 4ch1 PROTEIN SUP-12,
ISOFORM B
(Caenorhabditis
elegans) 		5 / 12 LEU A 109
ALA A  92
VAL A  81
GLY A  59
ILE A  37
 None
 1.00A 1hxbB-4ch1A:
undetectable		 1hxbB-4ch1A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 4ch1 PROTEIN SUP-12,
ISOFORM B
(Caenorhabditis
elegans) 		6 / 12 LEU A 109
ALA A  92
VAL A  81
ILE A  61
GLY A  59
ILE A  37
 None
 1.48A 2qakA-4ch1A:
undetectable		 2qakA-4ch1A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 4ch1 PROTEIN SUP-12,
ISOFORM B
(Caenorhabditis
elegans) 		4 / 6 TYR A 111
ALA A 110
LEU A 109
ALA A  89
 None
 0.87A 3b6hB-4ch1A:
undetectable		 3b6hB-4ch1A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_1
(HIV-1 PROTEASE)		 4ch1 PROTEIN SUP-12,
ISOFORM B
(Caenorhabditis
elegans) 		5 / 12 LEU A 109
ALA A  92
VAL A  81
GLY A  59
ILE A  37
 None
 1.05A 3mwsA-4ch1A:
undetectable		 3mwsA-4ch1A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_1
(PROTEASE)		 4ch1 PROTEIN SUP-12,
ISOFORM B
(Caenorhabditis
elegans) 		6 / 11 LEU A 109
ALA A  92
VAL A  81
ILE A  61
GLY A  59
ILE A  37
 None
 1.49A 4njtC-4ch1A:
undetectable		 4njtC-4ch1A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)		 4ch1 PROTEIN SUP-12,
ISOFORM B
(Caenorhabditis
elegans) 		5 / 11 GLY A  41
ILE A  37
ILE A  67
THR A  50
ILE A 100
 None
 0.98A 4njvC-4ch1A:
undetectable		 4njvC-4ch1A:
23.21