SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4chb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4chb KELCH-LIKE PROTEIN 2
(Homo
sapiens) 		5 / 12 VAL A 444
ALA A 419
LEU A 401
ALA A 471
ALA A 431
 None
 1.18A 1sa1A-4chbA:
undetectable
1sa1B-4chbA:
undetectable		 1sa1A-4chbA:
21.49
1sa1B-4chbA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 4chb KELCH-LIKE PROTEIN 2
(Homo
sapiens) 		3 / 3 ALA A 419
VAL A 405
TRP A 476
 None
 0.85A 1w5uC-4chbA:
undetectable
1w5uD-4chbA:
undetectable		 1w5uC-4chbA:
11.25
1w5uD-4chbA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4chb KELCH-LIKE PROTEIN 2
(Homo
sapiens) 		5 / 12 VAL A 509
SER A 487
SER A 439
THR A 392
GLY A 550
 None
 1.24A 2x2iA-4chbA:
2.1		 2x2iA-4chbA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 4chb KELCH-LIKE PROTEIN 2
(Homo
sapiens) 		3 / 3 GLU A 324
SER A 575
VAL A 573
 None
 0.80A 3eeoA-4chbA:
undetectable		 3eeoA-4chbA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 4chb KELCH-LIKE PROTEIN 2
(Homo
sapiens) 		3 / 3 ALA A 419
VAL A 405
TRP A 476
 None
 0.82A 3l8lC-4chbA:
undetectable
3l8lD-4chbA:
undetectable		 3l8lC-4chbA:
11.25
3l8lD-4chbA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4chb KELCH-LIKE PROTEIN 2
(Homo
sapiens) 		4 / 5 VAL A 397
LEU A 402
ILE A 422
ALA A 352
 None
 0.90A 3n8yB-4chbA:
undetectable		 3n8yB-4chbA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4chb KELCH-LIKE PROTEIN 2
(Homo
sapiens) 		5 / 12 GLN A 315
PHE A 361
ARG A 437
GLY A 360
SER A 391
 None
 1.24A 3sueD-4chbA:
undetectable		 3sueD-4chbA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 4chb KELCH-LIKE PROTEIN 2
(Homo
sapiens) 		4 / 6 PHE A 361
ARG A 345
LEU A 365
SER A 391
 None
 1.33A 3vlnA-4chbA:
undetectable		 3vlnA-4chbA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4chb KELCH-LIKE PROTEIN 2
(Homo
sapiens) 		3 / 3 TYR A 583
HIS A 504
ARG A 534
 None
 0.84A 4htfA-4chbA:
undetectable		 4htfA-4chbA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4chb KELCH-LIKE PROTEIN 2
(Homo
sapiens) 		3 / 3 ALA A 500
TYR A 499
PRO A 518
 None
 0.70A 4zdyA-4chbA:
undetectable		 4zdyA-4chbA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 4chb KELCH-LIKE PROTEIN 2
(Homo
sapiens) 		4 / 8 GLY A 407
TYR A 403
ALA A 396
GLY A 394
 None
 0.88A 5albL-4chbA:
undetectable		 5albL-4chbA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4chb KELCH-LIKE PROTEIN 2
(Homo
sapiens) 		3 / 3 TYR A 469
ALA A 419
TYR A 403
 None
 0.68A 5uunB-4chbA:
undetectable		 5uunB-4chbA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4chb KELCH-LIKE PROTEIN 2
(Homo
sapiens) 		5 / 12 ARG A 534
GLY A 553
VAL A 572
GLY A 549
SER A 582
 None
 1.06A 5vooC-4chbA:
undetectable		 5vooC-4chbA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4chb KELCH-LIKE PROTEIN 2
(Homo
sapiens) 		4 / 7 VAL A 452
VAL A 405
GLY A 443
TYR A 450
 None
 0.89A 5x80C-4chbA:
undetectable
5x80D-4chbA:
undetectable		 5x80C-4chbA:
21.51
5x80D-4chbA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 4chb KELCH-LIKE PROTEIN 2
(Homo
sapiens) 		5 / 12 LEU A 449
GLY A 394
GLY A 441
GLY A 490
ARG A 486
 None
 1.03A 6ce2B-4chbA:
undetectable		 6ce2B-4chbA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4chb KELCH-LIKE PROTEIN 2
(Homo
sapiens) 		4 / 5 GLY A 363
ASN A 362
ARG A 345
ARG A 343
 None
SO4  A1596 ( 3.9A)
None
SO4  A1596 (-3.0A)
 1.29A 6dwdB-4chbA:
undetectable
6dwdD-4chbA:
undetectable		 6dwdB-4chbA:
19.13
6dwdD-4chbA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4chb KELCH-LIKE PROTEIN 2
(Homo
sapiens) 		4 / 5 ARG A 345
ARG A 343
GLY A 363
ASN A 362
 None
SO4  A1596 (-3.0A)
None
SO4  A1596 ( 3.9A)
 1.34A 6dwjB-4chbA:
undetectable
6dwjD-4chbA:
undetectable		 6dwjB-4chbA:
19.13
6dwjD-4chbA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 4chb KELCH-LIKE PROTEIN 2
(Homo
sapiens) 		3 / 3 LYS A 307
VAL A 588
ASP A 590
 None
 0.32A 6fgdA-4chbA:
undetectable		 6fgdA-4chbA:
23.08