SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4chc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4chc POLYMERASE ACIDIC
PROTEIN
(Thogoto
thogotovirus) 		4 / 7 TYR A  57
VAL A  98
CYH A 129
ILE A 141
 None
 1.35A 2xz5B-4chcA:
undetectable
2xz5E-4chcA:
undetectable		 2xz5B-4chcA:
21.52
2xz5E-4chcA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA309_1
(BETA-LACTAMASE)		 4chc POLYMERASE ACIDIC
PROTEIN
(Thogoto
thogotovirus) 		4 / 5 ILE A 113
ARG A  65
THR A  84
GLU A  81
 None
 1.19A 3ny4A-4chcA:
undetectable		 3ny4A-4chcA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 4chc POLYMERASE ACIDIC
PROTEIN
(Thogoto
thogotovirus) 		4 / 6 VAL A  34
LEU A 100
ILE A 165
VAL A 152
 None
 0.91A 4a9kA-4chcA:
3.7		 4a9kA-4chcA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4chc POLYMERASE ACIDIC
PROTEIN
(Thogoto
thogotovirus) 		4 / 8 ILE A 165
PRO A   5
VAL A 152
TRP A 151
 None
 1.18A 4f4dB-4chcA:
undetectable		 4f4dB-4chcA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4chc POLYMERASE ACIDIC
PROTEIN
(Thogoto
thogotovirus) 		5 / 11 LEU A 100
CYH A  36
PRO A   5
VAL A 152
TRP A 151
 None
 1.35A 4mk4B-4chcA:
undetectable		 4mk4B-4chcA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4chc POLYMERASE ACIDIC
PROTEIN
(Thogoto
thogotovirus) 		4 / 6 PHE A 119
VAL A  98
ALA A 118
THR A 110
 None
 1.10A 5t7bA-4chcA:
undetectable		 5t7bA-4chcA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4chc POLYMERASE ACIDIC
PROTEIN
(Thogoto
thogotovirus) 		5 / 12 LEU A 100
ILE A  41
VAL A  12
LEU A 149
ALA A 148
 None
 1.18A 6djzA-4chcA:
undetectable		 6djzA-4chcA:
20.33