SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4chd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4chd POLYMERASE ACIDIC
PROTEIN
(Thogoto
thogotovirus) 		5 / 12 LEU A 555
TYR A 655
LEU A 648
PHE A 569
GLY A 630
 None
 1.12A 3kk6A-4chdA:
undetectable		 3kk6A-4chdA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4chd POLYMERASE ACIDIC
PROTEIN
(Thogoto
thogotovirus) 		5 / 12 LEU A 555
TYR A 655
LEU A 648
PHE A 569
GLY A 630
 None
 1.09A 3kk6B-4chdA:
undetectable		 3kk6B-4chdA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 4chd POLYMERASE ACIDIC
PROTEIN
(Thogoto
thogotovirus) 		3 / 3 ASP A 666
ARG A 617
ASP A 656
 None
 0.73A 4fp9A-4chdA:
undetectable		 4fp9A-4chdA:
17.93