SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4chg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 4chg PROBABLE
RIBONUCLEASE VAPC15
(Mycobacterium
tuberculosis) 		4 / 6 TYR A 117
ASP A 116
THR A   5
GLU A  42
 None
MN  A1133 (-3.0A)
None
MG  A1134 ( 3.8A)
 0.99A 2dttB-4chgA:
undetectable
2dttC-4chgA:
undetectable		 2dttB-4chgA:
20.29
2dttC-4chgA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_E_C2FE995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 4chg PROBABLE
RIBONUCLEASE VAPC15
ANTITOXIN VAPB15
(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis) 		5 / 11 ASP A  30
SER G  57
GLN G  55
LEU G  52
LEU A  59
 None
 1.49A 3fsuE-4chgA:
undetectable		 3fsuE-4chgA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4chg PROBABLE
RIBONUCLEASE VAPC15
(Mycobacterium
tuberculosis) 		5 / 12 VAL A   3
ARG A  92
GLY A 125
ALA A 119
ASP A 116
 None
None
None
None
MN  A1133 (-3.0A)
 1.07A 3sugA-4chgA:
undetectable		 3sugA-4chgA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4chg PROBABLE
RIBONUCLEASE VAPC15
ANTITOXIN VAPB15
(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis) 		3 / 3 THR A   5
ASN G  63
GLU A  42
 None
MG  A1134 ( 4.1A)
MG  A1134 ( 3.8A)
 0.71A 3v4tA-4chgA:
undetectable
3v4tC-4chgA:
undetectable		 3v4tA-4chgA:
18.89
3v4tC-4chgA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4chg ANTITOXIN VAPB15
PROBABLE
RIBONUCLEASE VAPC15
(Mycobacterium
tuberculosis) 		4 / 8 SER A   6
GLU G  67
VAL A 110
THR A 128
 None
MN  A1133 ( 1.9A)
None
None
 0.85A 4lnwA-4chgA:
undetectable		 4lnwA-4chgA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4chg ANTITOXIN VAPB15
PROBABLE
RIBONUCLEASE VAPC15
(Mycobacterium
tuberculosis) 		4 / 6 SER A   6
GLU G  67
VAL A 110
THR A 128
 None
MN  A1133 ( 1.9A)
None
None
 0.96A 4lnxA-4chgA:
undetectable		 4lnxA-4chgA:
22.87