SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4chl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 4chl PERSULFIDE
DIOXYGENASE ETHE1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 TYR A  38
PHE A 151
ILE A 158
GLY A 153
 None
 0.94A 11gsA-4chlA:
undetectable		 11gsA-4chlA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DY5_A_ACTA600_0
(RIBONUCLEASE A)		 4chl PERSULFIDE
DIOXYGENASE ETHE1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 HIS A  81
VAL A  76
ASN A  77
THR A  78
 None
 1.31A 1dy5A-4chlA:
undetectable		 1dy5A-4chlA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 4chl PERSULFIDE
DIOXYGENASE ETHE1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 THR A  57
LEU A  90
GLY A  87
LEU A  50
 None
 1.04A 1gtiD-4chlA:
undetectable		 1gtiD-4chlA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_B_BEZB1162_0
(PEROXIREDOXIN 5)		 4chl PERSULFIDE
DIOXYGENASE ETHE1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 THR A 136
PRO A 137
GLY A 138
CYH A 139
 None
 0.85A 1h4oB-4chlA:
undetectable		 1h4oB-4chlA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_G_BEZG1162_0
(PEROXIREDOXIN 5)		 4chl PERSULFIDE
DIOXYGENASE ETHE1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 THR A 136
PRO A 137
GLY A 138
CYH A 139
 None
 0.78A 1h4oG-4chlA:
undetectable		 1h4oG-4chlA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OC3_A_BEZA201_0
(PEROXIREDOXIN 5)		 4chl PERSULFIDE
DIOXYGENASE ETHE1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 THR A 136
PRO A 137
GLY A 138
CYH A 139
 None
 0.84A 1oc3A-4chlA:
undetectable		 1oc3A-4chlA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 4chl PERSULFIDE
DIOXYGENASE ETHE1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 8 HIS A  79
HIS A  81
ASP A 154
HIS A 195
GLY A 153
 FE  A 501 (-3.5A)
None
FE  A 501 (-3.1A)
None
None
 1.39A 3c0zB-4chlA:
undetectable		 3c0zB-4chlA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 4chl PERSULFIDE
DIOXYGENASE ETHE1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ASP A 165
HIS A  79
HIS A 135
ASP A  83
 None
FE  A 501 (-3.5A)
FE  A 501 (-3.4A)
None
 0.87A 3c0zC-4chlA:
undetectable		 3c0zC-4chlA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4chl PERSULFIDE
DIOXYGENASE ETHE1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 TYR A  38
PHE A 151
ILE A 158
GLY A 153
 None
 1.00A 3gssA-4chlA:
undetectable		 3gssA-4chlA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4chl PERSULFIDE
DIOXYGENASE ETHE1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 TYR A  38
PHE A 151
ILE A 158
GLY A 153
 None
 1.00A 3gssB-4chlA:
undetectable		 3gssB-4chlA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		 4chl PERSULFIDE
DIOXYGENASE ETHE1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 PRO A 137
SER A 106
LEU A 174
SER A 132
 None
 1.41A 3iluH-4chlA:
undetectable		 3iluH-4chlA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC202_1
(PROTEIN S100-A4)		 4chl PERSULFIDE
DIOXYGENASE ETHE1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 LEU A 217
SER A 218
PHE A 222
ILE A 225
GLU A 221
 None
 1.08A 3ko0A-4chlA:
undetectable
3ko0B-4chlA:
undetectable
3ko0C-4chlA:
undetectable
3ko0D-4chlA:
undetectable		 3ko0A-4chlA:
16.32
3ko0B-4chlA:
16.32
3ko0C-4chlA:
16.32
3ko0D-4chlA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF202_1
(PROTEIN S100-A4)		 4chl PERSULFIDE
DIOXYGENASE ETHE1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 GLU A 221
LEU A 217
SER A 218
PHE A 222
ILE A 225
 None
 1.03A 3ko0E-4chlA:
undetectable
3ko0F-4chlA:
undetectable
3ko0G-4chlA:
undetectable
3ko0H-4chlA:
undetectable		 3ko0E-4chlA:
16.32
3ko0F-4chlA:
16.32
3ko0G-4chlA:
16.32
3ko0H-4chlA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH202_1
(PROTEIN S100-A4)		 4chl PERSULFIDE
DIOXYGENASE ETHE1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLU A 221
LEU A 217
SER A 218
PHE A 222
ILE A 225
 None
 1.14A 3ko0G-4chlA:
undetectable
3ko0H-4chlA:
undetectable
3ko0I-4chlA:
undetectable
3ko0J-4chlA:
undetectable		 3ko0G-4chlA:
16.32
3ko0H-4chlA:
16.32
3ko0I-4chlA:
16.32
3ko0J-4chlA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 4chl PERSULFIDE
DIOXYGENASE ETHE1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 217
SER A 218
PHE A 222
ILE A 225
GLU A 221
 None
 1.13A 3ko0M-4chlA:
undetectable
3ko0N-4chlA:
undetectable
3ko0O-4chlA:
undetectable
3ko0P-4chlA:
undetectable		 3ko0M-4chlA:
16.32
3ko0N-4chlA:
16.32
3ko0O-4chlA:
16.32
3ko0P-4chlA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN202_1
(PROTEIN S100-A4)		 4chl PERSULFIDE
DIOXYGENASE ETHE1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 GLU A 221
LEU A 217
SER A 218
PHE A 222
ILE A 225
 None
 1.21A 3ko0K-4chlA:
undetectable
3ko0L-4chlA:
undetectable
3ko0M-4chlA:
undetectable
3ko0N-4chlA:
undetectable		 3ko0K-4chlA:
16.32
3ko0L-4chlA:
16.32
3ko0M-4chlA:
16.32
3ko0N-4chlA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 4chl PERSULFIDE
DIOXYGENASE ETHE1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 HIS A 135
GLY A 153
HIS A  81
ASP A  83
HIS A  84
 FE  A 501 (-3.4A)
None
None
None
None
 1.25A 4bz6C-4chlA:
undetectable		 4bz6C-4chlA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 4chl PERSULFIDE
DIOXYGENASE ETHE1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 HIS A  79
HIS A  81
ASP A 154
HIS A 195
GLY A 153
 FE  A 501 (-3.5A)
None
FE  A 501 (-3.1A)
None
None
 1.41A 4lxzB-4chlA:
undetectable		 4lxzB-4chlA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 4chl PERSULFIDE
DIOXYGENASE ETHE1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 ILE A 158
THR A 204
SER A 203
ASP A 196
GLU A 207
 None
 1.32A 4xt7A-4chlA:
undetectable		 4xt7A-4chlA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 4chl PERSULFIDE
DIOXYGENASE ETHE1,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 HIS A  81
ASN A 244
ALA A 108
 None
 0.70A 5n4tB-4chlA:
7.0		 5n4tB-4chlA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1015_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 4chl PERSULFIDE
DIOXYGENASE ETHE1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ASP A  83
ILE A  51
ASP A  52
ASP A 154
LEU A 157
 None
None
None
FE  A 501 (-3.1A)
None
 1.46A 5nn8A-4chlA:
2.4		 5nn8A-4chlA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4chl PERSULFIDE
DIOXYGENASE ETHE1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ASP A 146
VAL A 205
GLY A 187
ARG A 209
 None
 1.02A 5nzyA-4chlA:
6.4		 5nzyA-4chlA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 4chl PERSULFIDE
DIOXYGENASE ETHE1,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 HIS A 195
ASP A  83
HIS A  84
 None
 0.78A 5oexA-4chlA:
undetectable		 5oexA-4chlA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 4chl PERSULFIDE
DIOXYGENASE ETHE1,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 HIS A 195
ASP A 154
HIS A  79
 None
FE  A 501 (-3.1A)
FE  A 501 (-3.5A)
 0.80A 5oexA-4chlA:
undetectable		 5oexA-4chlA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 4chl PERSULFIDE
DIOXYGENASE ETHE1,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 HIS A 135
HIS A  79
HIS A  81
 FE  A 501 (-3.4A)
FE  A 501 (-3.5A)
None
 0.99A 5oexA-4chlA:
undetectable		 5oexA-4chlA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 4chl PERSULFIDE
DIOXYGENASE ETHE1,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 HIS A 195
ASP A  83
HIS A  84
 None
 0.75A 5oexB-4chlA:
undetectable		 5oexB-4chlA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 4chl PERSULFIDE
DIOXYGENASE ETHE1,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 HIS A 195
ASP A  83
HIS A  84
 None
 0.73A 5oexC-4chlA:
undetectable		 5oexC-4chlA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 4chl PERSULFIDE
DIOXYGENASE ETHE1,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 HIS A 195
ASP A  83
HIS A  84
 None
 0.70A 5oexD-4chlA:
undetectable		 5oexD-4chlA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4chl PERSULFIDE
DIOXYGENASE ETHE1,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 LEU A 229
ASN A 212
LEU A 174
 None
 0.56A 6exiD-4chlA:
undetectable		 6exiD-4chlA:
15.55