SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4chm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 4chm IMC SUB-COMPARTMENT
PROTEIN ISP1
(Toxoplasma
gondii) 		3 / 3 LEU A  81
ASN A 135
ARG A 157
 None
None
SO4  A1182 (-3.0A)
 0.78A 2qhfA-4chmA:
undetectable		 2qhfA-4chmA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4chm IMC SUB-COMPARTMENT
PROTEIN ISP1
(Toxoplasma
gondii) 		4 / 7 ILE A 112
HIS A 146
LEU A 120
ALA A 144
 None
 0.94A 5hrqE-4chmA:
undetectable
5hrqF-4chmA:
undetectable
5hrqJ-4chmA:
undetectable		 5hrqE-4chmA:
12.17
5hrqF-4chmA:
11.50
5hrqJ-4chmA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 4chm IMC SUB-COMPARTMENT
PROTEIN ISP1
(Toxoplasma
gondii) 		5 / 12 ILE A 117
VAL A 168
LEU A 101
LEU A 156
LEU A  92
 None
 1.09A 5tiwA-4chmA:
undetectable		 5tiwA-4chmA:
20.48