SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ci0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1CD2_A_FOLA307_1 (DIHYDROFOLATE REDUCTASE)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT ALPHA (Methanothermobac ter marburgensis)	3 / 3	GLU A 325 ILE A 324 ARG A 219	None	0.66A	1cd2A-4ci0A: undetectable	1cd2A-4ci0A: 22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1W0G_A_MYTA1499_1 (CYTOCHROME P450 3A4)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT ALPHA (Methanothermobac ter marburgensis)	4 / 6	SER A 129 ILE A 133 ALA A 107 ALA A 114	None	0.79A	1w0gA-4ci0A: 0.1	1w0gA-4ci0A: 21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ZEA_A_DHIA6_0 (MONOCLONAL ANTI-CHOLERA TOXIN IGG1 KAPPA ANTIBODY, H CHAIN MONOCLONAL ANTI-CHOLERA TOXIN IGG1 KAPPA ANTIBODY, L CHAIN SHORT SYNTHETIC D-AMINO ACID PEPTIDE D2)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT GAMMA F420-REDUCING HYDROGENASE, SUBUNIT BETA (Methanothermobac ter marburgensis; Methanothermobac ter marburgensis)	3 / 3	TRP B 264 ARG B 261 PHE C 281	None SF4 C1282 ( 4.4A) None	1.22A	1zeaH-4ci0B: undetectable 1zeaL-4ci0B: undetectable	1zeaH-4ci0B: 20.79 1zeaL-4ci0B: 23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2CP4_A_CAMA416_0 (CYTOCHROME P450-CAM)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT BETA (Methanothermobac ter marburgensis)	5 / 10	THR C 207 LEU C 33 VAL C 29 GLY C 31 VAL C 219	FAD C1283 (-4.6A) None FAD C1283 (-4.0A) None None	1.32A	2cp4A-4ci0C: undetectable	2cp4A-4ci0C: 20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2JN3_A_JN3A130_1 (FATTY ACID-BINDING PROTEIN, LIVER)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT ALPHA (Methanothermobac ter marburgensis)	5 / 12	LEU A 188 ILE A 127 HIS A 280 ILE A 193 LEU A 192	None	1.09A	2jn3A-4ci0A: undetectable	2jn3A-4ci0A: 16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QHF_A_ACTA502_0 (CHORISMATE SYNTHASE)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT GAMMA (Methanothermobac ter marburgensis)	3 / 3	GLY B 59 ASP B 60 SER B 63	SF4 B1274 (-3.5A) SF4 B1274 (-1.7A) None	0.74A	2qhfA-4ci0B: undetectable	2qhfA-4ci0B: 20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VD0_B_D27B1200_0 (GLUTATHIONE-REQUIRIN G PROSTAGLANDIN D SYNTHASE)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT BETA (Methanothermobac ter marburgensis)	5 / 10	GLY C 131 ARG C 222 ALA C 225 THR C 106 LEU C 129	None	1.38A	2vd0B-4ci0C: undetectable	2vd0B-4ci0C: 21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W9S_E_TOPE1160_1 (DIHYDROFOLATE REDUCTASE TYPE 1 FROM TN4003)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT ALPHA F420-REDUCING HYDROGENASE, SUBUNIT GAMMA (Methanothermobac ter marburgensis)	4 / 8	ALA B 61 LEU B 87 ILE A 108 THR B 58	None	0.76A	2w9sE-4ci0B: undetectable	2w9sE-4ci0B: 17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X7H_A_PFNA1374_1 (ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT BETA (Methanothermobac ter marburgensis)	4 / 6	PRO C 139 SER C 142 GLU C 136 CYH C 192	None None None SF4 C1282 (-1.9A)	1.09A	2x7hA-4ci0C: undetectable	2x7hA-4ci0C: 22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZGW_B_ADNB1302_1 (BIOTIN--[ACETYL-COA- CARBOXYLASE] LIGASE)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT ALPHA (Methanothermobac ter marburgensis)	4 / 6	GLU A 165 ALA A 89 ASN A 162 ALA A 305	None	1.20A	2zgwB-4ci0A: undetectable	2zgwB-4ci0A: 19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZJ0_B_2FAB500_2 (ADENOSYLHOMOCYSTEINA SE)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT ALPHA F420-REDUCING HYDROGENASE, SUBUNIT GAMMA (Methanothermobac ter marburgensis)	4 / 5	LEU A 381 THR A 351 THR B 86 HIS B 53	None	1.24A	2zj0B-4ci0A: undetectable	2zj0B-4ci0A: 21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EEY_D_SAMD300_0 (PUTATIVE RRNA METHYLASE)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT GAMMA (Methanothermobac ter marburgensis)	5 / 12	GLY B 207 ILE B 254 GLY B 170 LEU B 235 THR B 232	SF4 B1275 ( 4.0A) SF4 B1275 ( 4.6A) None SF4 B1275 (-3.7A) SF4 B1275 (-3.4A)	1.18A	3eeyD-4ci0B: undetectable	3eeyD-4ci0B: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EEY_J_SAMJ300_0 (PUTATIVE RRNA METHYLASE)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT GAMMA (Methanothermobac ter marburgensis)	5 / 12	GLY B 207 ILE B 254 GLY B 170 LEU B 235 THR B 232	SF4 B1275 ( 4.0A) SF4 B1275 ( 4.6A) None SF4 B1275 (-3.7A) SF4 B1275 (-3.4A)	1.12A	3eeyJ-4ci0B: undetectable	3eeyJ-4ci0B: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FL9_C_TOPC200_1 (DIHYDROFOLATE REDUCTASE (DHFR))	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT BETA F420-REDUCING HYDROGENASE, SUBUNIT GAMMA (Methanothermobac ter marburgensis)	5 / 11	ALA C 101 ASN C 137 VAL C 82 ILE B 221 THR C 99	None SF4 C1282 ( 3.7A) None SF4 C1282 ( 3.6A) None	1.34A	3fl9C-4ci0C: undetectable	3fl9C-4ci0C: 20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FL9_E_TOPE200_1 (DIHYDROFOLATE REDUCTASE (DHFR))	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT GAMMA (Methanothermobac ter marburgensis)	5 / 10	LEU B 100 LEU B 64 ILE B 81 LEU B 75 THR B 181	None	1.10A	3fl9E-4ci0B: undetectable	3fl9E-4ci0B: 19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3J6P_B_TA1B502_1 (TUBULIN BETA CHAIN)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT ALPHA (Methanothermobac ter marburgensis)	5 / 12	GLU A 325 LEU A 319 SER A 212 PHE A 222 LEU A 348	None	1.02A	3j6pB-4ci0A: undetectable	3j6pB-4ci0A: 20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K13_C_THHC643_1 (5-METHYLTETRAHYDROFO LATE-HOMOCYSTEINE METHYLTRANSFERASE)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT ALPHA F420-REDUCING HYDROGENASE, SUBUNIT GAMMA (Methanothermobac ter marburgensis; Methanothermobac ter marburgensis)	3 / 3	ASN B 245 ASP B 236 ARG A 94	None	0.88A	3k13C-4ci0B: undetectable	3k13C-4ci0B: 22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N2O_C_AG2C1002_1 (BIOSYNTHETIC ARGININE DECARBOXYLASE)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT BETA (Methanothermobac ter marburgensis)	4 / 8	SER C 65 ASP C 16 LEU C 238 ASP C 38	None	0.99A	3n2oC-4ci0C: undetectable 3n2oD-4ci0C: undetectable	3n2oC-4ci0C: 19.17 3n2oD-4ci0C: 19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OKX_A_SAMA201_0 (YAEB-LIKE PROTEIN RPA0152)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT BETA (Methanothermobac ter marburgensis)	5 / 12	LEU C 253 TYR C 133 GLY C 208 THR C 207 SER C 206	None None FAD C1283 (-3.6A) FAD C1283 (-4.6A) None	1.26A	3okxA-4ci0C: undetectable	3okxA-4ci0C: 20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OKX_A_SAMA201_0 (YAEB-LIKE PROTEIN RPA0152)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT BETA (Methanothermobac ter marburgensis)	5 / 12	LEU C 253 TYR C 133 THR C 207 SER C 206 LEU C 257	None None FAD C1283 (-4.6A) None None	1.38A	3okxA-4ci0C: undetectable	3okxA-4ci0C: 20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OKX_B_SAMB201_1 (YAEB-LIKE PROTEIN RPA0152)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT BETA (Methanothermobac ter marburgensis)	5 / 12	LEU C 253 TYR C 133 GLY C 208 THR C 207 LEU C 257	None None FAD C1283 (-3.6A) FAD C1283 (-4.6A) None	1.19A	3okxB-4ci0C: undetectable	3okxB-4ci0C: 20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OKX_B_SAMB201_1 (YAEB-LIKE PROTEIN RPA0152)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT BETA (Methanothermobac ter marburgensis)	5 / 12	LEU C 253 TYR C 133 GLY C 208 THR C 207 SER C 206	None None FAD C1283 (-3.6A) FAD C1283 (-4.6A) None	1.26A	3okxB-4ci0C: undetectable	3okxB-4ci0C: 20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QEL_B_QELB1_1 (NMDA GLUTAMATE RECEPTOR SUBUNIT GLUTAMATE [NMDA] RECEPTOR SUBUNIT EPSILON-2)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT ALPHA F420-REDUCING HYDROGENASE, SUBUNIT GAMMA (Methanothermobac ter marburgensis)	5 / 11	TYR B 68 ALA A 107 ILE A 133 THR B 58 GLU A 14	None	1.28A	3qelA-4ci0B: undetectable 3qelB-4ci0B: undetectable	3qelA-4ci0B: 21.59 3qelB-4ci0B: 22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TBG_A_RTZA2_1 (CYTOCHROME P450 2D6)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT ALPHA F420-REDUCING HYDROGENASE, SUBUNIT GAMMA (Methanothermobac ter marburgensis)	5 / 11	THR A 351 VAL A 349 LEU A 43 VAL A 40 PHE B 138	None	1.32A	3tbgA-4ci0A: 0.7	3tbgA-4ci0A: 24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TBG_A_RTZA2_1 (CYTOCHROME P450 2D6)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT ALPHA F420-REDUCING HYDROGENASE, SUBUNIT GAMMA (Methanothermobac ter marburgensis)	5 / 11	VAL A 349 LEU A 43 VAL A 40 THR A 385 PHE B 138	None	1.38A	3tbgA-4ci0A: 0.7	3tbgA-4ci0A: 24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TBG_C_RTZC2_1 (CYTOCHROME P450 2D6)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT ALPHA F420-REDUCING HYDROGENASE, SUBUNIT GAMMA (Methanothermobac ter marburgensis)	5 / 10	THR A 351 VAL A 349 LEU A 43 VAL A 40 PHE B 138	None	1.38A	3tbgC-4ci0A: undetectable	3tbgC-4ci0A: 24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TBG_C_RTZC2_1 (CYTOCHROME P450 2D6)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT ALPHA F420-REDUCING HYDROGENASE, SUBUNIT GAMMA (Methanothermobac ter marburgensis)	5 / 10	VAL A 349 LEU A 43 VAL A 40 THR A 385 PHE B 138	None	1.39A	3tbgC-4ci0A: undetectable	3tbgC-4ci0A: 24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UR0_C_SVRC516_1 (RNA-DEPENDENT RNA POLYMERASE)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT ALPHA (Methanothermobac ter marburgensis)	5 / 9	PRO A 327 GLY A 329 ALA A 326 ALA A 73 LEU A 98	None None FE A1387 ( 3.9A) None None	1.48A	3ur0C-4ci0A: undetectable	3ur0C-4ci0A: 21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B9Z_A_ACRA1818_1 (ALPHA-GLUCOSIDASE, PUTATIVE, ADG31B)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT ALPHA (Methanothermobac ter marburgensis)	5 / 12	LEU A 224 ILE A 321 LEU A 348 GLU A 229 PHE A 344	None None None FE2 A1389 ( 4.3A) None	1.46A	4b9zA-4ci0A: undetectable	4b9zA-4ci0A: 20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EJJ_D_NCTD501_1 (CYTOCHROME P450 2A6)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT BETA (Methanothermobac ter marburgensis)	4 / 7	GLY C 211 THR C 218 ILE C 220 LEU C 3	None	0.84A	4ejjD-4ci0C: undetectable	4ejjD-4ci0C: 20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IIL_A_RBFA401_2 (MEMBRANE LIPOPROTEIN TPN38(B))	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT ALPHA (Methanothermobac ter marburgensis)	4 / 8	VAL A 140 ASN A 136 GLN A 177 ILE A 295	None	0.99A	4iilA-4ci0A: undetectable	4iilA-4ci0A: 24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IK7_A_IMNA201_1 (TRANSTHYRETIN)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT BETA (Methanothermobac ter marburgensis)	4 / 7	LEU C 128 THR C 207 THR C 221 VAL C 219	None FAD C1283 (-4.6A) None None	0.66A	4ik7A-4ci0C: undetectable	4ik7A-4ci0C: 19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IK7_B_IMNB201_1 (TRANSTHYRETIN)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT BETA (Methanothermobac ter marburgensis)	4 / 8	LEU C 128 THR C 207 THR C 221 VAL C 219	None FAD C1283 (-4.6A) None None	0.57A	4ik7B-4ci0C: undetectable	4ik7B-4ci0C: 19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MK4_A_CHDA504_0 (FERROCHELATASE, MITOCHONDRIAL)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT ALPHA F420-REDUCING HYDROGENASE, SUBUNIT BETA (Methanothermobac ter marburgensis; Methanothermobac ter marburgensis)	4 / 8	SER A 152 ARG A 155 VAL C 119 GLY C 118	None	0.97A	4mk4A-4ci0A: undetectable	4mk4A-4ci0A: 20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RJD_B_TFPB204_1 (CALMODULIN)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT ALPHA (Methanothermobac ter marburgensis)	4 / 8	LEU A 330 GLY A 329 GLU A 286 ALA A 282	None	0.62A	4rjdA-4ci0A: undetectable 4rjdB-4ci0A: undetectable	4rjdA-4ci0A: 13.79 4rjdB-4ci0A: 13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RP8_C_ASCC501_0 (ASCORBATE-SPECIFIC PERMEASE IIC COMPONENT ULAA)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT GAMMA (Methanothermobac ter marburgensis)	5 / 12	LEU B 199 ILE B 254 GLN B 258 ALA B 134 ILE B 177	None SF4 B1275 ( 4.6A) None None None	1.21A	4rp8C-4ci0B: undetectable	4rp8C-4ci0B: 18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4W5O_A_IPHA907_0 (PROTEIN ARGONAUTE-2)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT GAMMA (Methanothermobac ter marburgensis)	4 / 5	ALA B 167 THR B 135 THR B 203 TYR B 202	None	1.36A	4w5oA-4ci0B: 2.1	4w5oA-4ci0B: 16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4W5Q_A_IPHA905_0 (PROTEIN ARGONAUTE-2)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT GAMMA (Methanothermobac ter marburgensis)	4 / 6	ALA B 167 THR B 135 THR B 203 TYR B 202	None	1.35A	4w5qA-4ci0B: undetectable	4w5qA-4ci0B: 16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4W5R_A_IPHA905_0 (PROTEIN ARGONAUTE-2)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT GAMMA (Methanothermobac ter marburgensis)	4 / 6	ALA B 167 THR B 135 THR B 203 TYR B 202	None	1.34A	4w5rA-4ci0B: undetectable	4w5rA-4ci0B: 16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4W5T_A_IPHA905_0 (PROTEIN ARGONAUTE-2)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT GAMMA (Methanothermobac ter marburgensis)	4 / 6	ALA B 167 THR B 135 THR B 203 TYR B 202	None	1.34A	4w5tA-4ci0B: 2.5	4w5tA-4ci0B: 16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XE3_B_CL6B502_1 (CYTOCHROME P-450)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT BETA (Methanothermobac ter marburgensis)	4 / 5	LEU C 128 ALA C 203 VAL C 219 ILE C 220	None	0.97A	4xe3B-4ci0C: undetectable	4xe3B-4ci0C: 21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z4C_A_IPHA906_0 (PROTEIN ARGONAUTE-2)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT GAMMA (Methanothermobac ter marburgensis)	4 / 6	ALA B 167 THR B 135 THR B 203 TYR B 202	None	1.36A	4z4cA-4ci0B: undetectable	4z4cA-4ci0B: 16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z4D_A_IPHA905_0 (PROTEIN ARGONAUTE-2)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT GAMMA (Methanothermobac ter marburgensis)	4 / 5	ALA B 167 THR B 135 THR B 203 TYR B 202	None	1.36A	4z4dA-4ci0B: undetectable	4z4dA-4ci0B: 16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z4E_A_IPHA907_0 (PROTEIN ARGONAUTE-2)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT GAMMA (Methanothermobac ter marburgensis)	4 / 5	ALA B 167 THR B 135 THR B 203 TYR B 202	None	1.36A	4z4eA-4ci0B: 1.9	4z4eA-4ci0B: 16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z4F_A_IPHA904_0 (PROTEIN ARGONAUTE-2)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT GAMMA (Methanothermobac ter marburgensis)	4 / 6	ALA B 167 THR B 135 THR B 203 TYR B 202	None	1.36A	4z4fA-4ci0B: 2.4	4z4fA-4ci0B: 16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z4G_A_IPHA905_0 (PROTEIN ARGONAUTE-2)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT GAMMA (Methanothermobac ter marburgensis)	4 / 5	ALA B 167 THR B 135 THR B 203 TYR B 202	None	1.35A	4z4gA-4ci0B: 2.5	4z4gA-4ci0B: 16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z4I_A_IPHA904_0 (PROTEIN ARGONAUTE-2)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT GAMMA (Methanothermobac ter marburgensis)	4 / 6	ALA B 167 THR B 135 THR B 203 TYR B 202	None	1.34A	4z4iA-4ci0B: 2.5	4z4iA-4ci0B: 16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZO1_X_T3X500_1 (THYROID HORMONE RECEPTOR BETA)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT ALPHA (Methanothermobac ter marburgensis)	5 / 12	ILE A 133 ALA A 137 ALA A 290 LEU A 291 HIS A 110	None	1.49A	4zo1X-4ci0A: undetectable	4zo1X-4ci0A: 22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5B8I_C_FK5C201_2 (CALCINEURIN SUBUNIT B, VARIANT PEPTIDYL-PROLYL CIS-TRANS ISOMERASE)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT ALPHA (Methanothermobac ter marburgensis)	4 / 4	LEU A 291 MET A 287 VAL A 103 ASN A 104	None	1.27A	5b8iB-4ci0A: 0.2	5b8iB-4ci0A: 19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CP4_A_CAMA422_0 (CYTOCHROME P450CAM)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT BETA (Methanothermobac ter marburgensis)	5 / 9	THR C 207 LEU C 33 VAL C 29 GLY C 31 VAL C 219	FAD C1283 (-4.6A) None FAD C1283 (-4.0A) None None	1.31A	5cp4A-4ci0C: undetectable	5cp4A-4ci0C: 20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EWJ_D_QELD503_1 (NMDA GLUTAMATE RECEPTOR SUBUNIT GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT ALPHA F420-REDUCING HYDROGENASE, SUBUNIT GAMMA (Methanothermobac ter marburgensis)	5 / 12	TYR B 68 ALA A 107 ILE A 133 THR B 58 GLU A 14	None	1.30A	5ewjC-4ci0B: 2.3 5ewjD-4ci0B: 2.5	5ewjC-4ci0B: 21.57 5ewjD-4ci0B: 22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HWA_A_GCSA303_1 (CHITOSANASE)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT ALPHA (Methanothermobac ter marburgensis)	4 / 5	HIS A 150 VAL A 141 GLY A 146 ALA A 145	SF4 B1274 ( 4.4A) None None None	0.95A	5hwaA-4ci0A: 1.7	5hwaA-4ci0A: 20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IEP_A_VDYA201_2 (CDL2.3B)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT GAMMA (Methanothermobac ter marburgensis)	5 / 9	ILE B 178 PRO B 175 VAL B 257 ILE B 254 LEU B 100	None None None SF4 B1275 ( 4.6A) None	1.46A	5iepA-4ci0B: undetectable	5iepA-4ci0B: 19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5J2T_C_VLBC503_2 (TUBULIN ALPHA-1B CHAIN)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT BETA (Methanothermobac ter marburgensis)	5 / 12	VAL C 29 ALA C 34 VAL C 130 GLY C 131 ILE C 132	FAD C1283 (-4.0A) None None None FAD C1283 (-3.6A)	0.79A	5j2tC-4ci0C: undetectable	5j2tC-4ci0C: 20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JHD_E_EDTE301_0 (BETA-2-MICROGLOBULIN TCRBETA CHAIN)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT ALPHA (Methanothermobac ter marburgensis)	4 / 8	TYR A 34 SER A 36 THR A 385 PRO A 9	None	1.11A	5jhdE-4ci0A: undetectable 5jhdG-4ci0A: undetectable	5jhdE-4ci0A: 20.05 5jhdG-4ci0A: 16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JMN_C_FUAC1101_1 (MULTIDRUG EFFLUX PUMP SUBUNIT ACRB)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT ALPHA (Methanothermobac ter marburgensis)	3 / 3	VAL A 154 HIS A 70 VAL A 59	None FE A1387 ( 4.6A) None	0.68A	5jmnC-4ci0A: undetectable	5jmnC-4ci0A: 18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NFP_A_8W5A804_2 (GLUCOCORTICOID RECEPTOR)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT ALPHA (Methanothermobac ter marburgensis)	4 / 4	LEU A 96 MET A 159 ILE A 215 LEU A 72	None	1.29A	5nfpA-4ci0A: undetectable	5nfpA-4ci0A: 19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NNA_A_BZMA301_0 (ISATIN HYDROLASE A)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT BETA (Methanothermobac ter marburgensis)	5 / 12	ILE C 220 LEU C 3 SER C 212 GLY C 208 GLY C 211	None None None FAD C1283 (-3.6A) None	1.12A	5nnaA-4ci0C: undetectable	5nnaA-4ci0C: 21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NNA_B_BZMB301_0 (ISATIN HYDROLASE A)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT BETA (Methanothermobac ter marburgensis)	5 / 12	ILE C 220 LEU C 3 SER C 212 GLY C 208 GLY C 211	None None None FAD C1283 (-3.6A) None	1.13A	5nnaB-4ci0C: undetectable	5nnaB-4ci0C: 21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NNA_C_BZMC301_0 (ISATIN HYDROLASE A)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT BETA (Methanothermobac ter marburgensis)	5 / 12	ILE C 220 LEU C 3 SER C 212 GLY C 208 GLY C 211	None None None FAD C1283 (-3.6A) None	1.12A	5nnaC-4ci0C: undetectable	5nnaC-4ci0C: 21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NNA_D_BZMD301_0 (ISATIN HYDROLASE A)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT BETA (Methanothermobac ter marburgensis)	5 / 12	ILE C 220 LEU C 3 SER C 212 GLY C 208 GLY C 211	None None None FAD C1283 (-3.6A) None	1.11A	5nnaD-4ci0C: undetectable	5nnaD-4ci0C: 21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VOO_F_C2FF3001_0 (5-METHYLTETRAHYDROFO LATE HOMOCYSTEINE S-METHYLTRANSFERASE)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT BETA (Methanothermobac ter marburgensis)	5 / 12	GLY C 226 LEU C 68 GLY C 98 ARG C 110 ILE C 42	None	1.11A	5vooF-4ci0C: undetectable	5vooF-4ci0C: 25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VOP_B_C2FB3001_0 (5-METHYLTETRAHYDROFO LATE HOMOCYSTEINE S-METHYLTRANSFERASE)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT BETA (Methanothermobac ter marburgensis)	5 / 12	GLY C 226 LEU C 68 GLY C 98 ARG C 110 ILE C 42	None	1.15A	5vopB-4ci0C: undetectable	5vopB-4ci0C: 25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6A5Y_D_9CRD501_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT ALPHA (Methanothermobac ter marburgensis)	3 / 3	ASN A 104 VAL A 186 HIS A 185	None	0.79A	6a5yD-4ci0A: undetectable	6a5yD-4ci0A: 13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EF6_A_ACTA405_0 (AMINOGLYCOSIDE PHOSPHOTRANSFERASE)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT ALPHA F420-REDUCING HYDROGENASE, SUBUNIT GAMMA F420-REDUCING HYDROGENASE, SUBUNIT BETA (Methanothermobac ter marburgensis; Methanothermobac ter marburgensis; Methanothermobac ter marburgensis)	4 / 6	ARG A 134 PRO B 175 ARG C 120 ILE A 149	None	1.34A	6ef6A-4ci0A: undetectable	6ef6A-4ci0A: 22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EQP_A_BUWA601_1 (CHOLINESTERASE)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT ALPHA (Methanothermobac ter marburgensis)	4 / 8	GLY A 275 GLN A 279 PHE A 365 TYR A 369	None	1.01A	6eqpA-4ci0A: undetectable	6eqpA-4ci0A: 12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EXI_D_ADND502_1 (ADENOSYLHOMOCYSTEINA SE)	4ci0	F420-REDUCING HYDROGENASE, SUBUNIT GAMMA (Methanothermobac ter marburgensis)	3 / 3	LEU B 100 ASN B 67 LEU B 75	None	0.67A	6exiD-4ci0B: undetectable	6exiD-4ci0B: 14.96

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1CD2_A_FOLA307_1","DIHYDROFOLATE REDUCTASE","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT ALPHA","Methanothermobacter marburgensis",3,"GLU A 325;ILE A 324;ARG A 219","None","0.66A","1cd2A-4ci0A:undetectable","1cd2A-4ci0A:22.56"],["1W0G_A_MYTA1499_1","CYTOCHROME P450 3A4","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT ALPHA","Methanothermobacter marburgensis",4,"SER A 129;ILE A 133;ALA A 107;ALA A 114","None","0.79A","1w0gA-4ci0A:0.1","1w0gA-4ci0A:21.14"],["1ZEA_A_DHIA6_0","MONOCLONAL ANTI-CHOLERA TOXIN IGG1 KAPPA ANTIBODY, H CHAIN;MONOCLONAL ANTI-CHOLERA TOXIN IGG1 KAPPA ANTIBODY, L CHAIN;SHORT SYNTHETIC D-AMINO ACID PEPTIDE D2","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT GAMMA;F420-REDUCING HYDROGENASE, SUBUNIT BETA","Methanothermobacter marburgensis;Methanothermobacter marburgensis",3,"TRP B 264;ARG B 261;PHE C 281","None;SF4 C1282 ( 4.4A);None","1.22A","1zeaH-4ci0B:undetectable;1zeaL-4ci0B:undetectable","1zeaH-4ci0B:20.79;1zeaL-4ci0B:23.02"],["2CP4_A_CAMA416_0","CYTOCHROME P450-CAM","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT BETA","Methanothermobacter marburgensis",5,"THR C 207;LEU C  33;VAL C  29;GLY C  31;VAL C 219","FAD C1283 (-4.6A);None;FAD C1283 (-4.0A);None;None","1.32A","2cp4A-4ci0C:undetectable","2cp4A-4ci0C:20.88"],["2JN3_A_JN3A130_1","FATTY ACID-BINDING PROTEIN, LIVER","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT ALPHA","Methanothermobacter marburgensis",5,"LEU A 188;ILE A 127;HIS A 280;ILE A 193;LEU A 192","None","1.09A","2jn3A-4ci0A:undetectable","2jn3A-4ci0A:16.96"],["2QHF_A_ACTA502_0","CHORISMATE SYNTHASE","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT GAMMA","Methanothermobacter marburgensis",3,"GLY B  59;ASP B  60;SER B  63","SF4 B1274 (-3.5A);SF4 B1274 (-1.7A);None","0.74A","2qhfA-4ci0B:undetectable","2qhfA-4ci0B:20.72"],["2VD0_B_D27B1200_0","GLUTATHIONE-REQUIRING PROSTAGLANDIN D SYNTHASE","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT BETA","Methanothermobacter marburgensis",5,"GLY C 131;ARG C 222;ALA C 225;THR C 106;LEU C 129","None","1.38A","2vd0B-4ci0C:undetectable","2vd0B-4ci0C:21.05"],["2W9S_E_TOPE1160_1","DIHYDROFOLATE REDUCTASE TYPE 1 FROM TN4003","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT ALPHA;F420-REDUCING HYDROGENASE, SUBUNIT GAMMA","Methanothermobacter marburgensis",4,"ALA B  61;LEU B  87;ILE A 108;THR B  58","None","0.76A","2w9sE-4ci0B:undetectable","2w9sE-4ci0B:17.73"],["2X7H_A_PFNA1374_1","ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT BETA","Methanothermobacter marburgensis",4,"PRO C 139;SER C 142;GLU C 136;CYH C 192","None;None;None;SF4 C1282 (-1.9A)","1.09A","2x7hA-4ci0C:undetectable","2x7hA-4ci0C:22.31"],["2ZGW_B_ADNB1302_1","BIOTIN--[ACETYL-COA-CARBOXYLASE] LIGASE","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT ALPHA","Methanothermobacter marburgensis",4,"GLU A 165;ALA A  89;ASN A 162;ALA A 305","None","1.20A","2zgwB-4ci0A:undetectable","2zgwB-4ci0A:19.14"],["2ZJ0_B_2FAB500_2","ADENOSYLHOMOCYSTEINASE","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT ALPHA;F420-REDUCING HYDROGENASE, SUBUNIT GAMMA","Methanothermobacter marburgensis",4,"LEU A 381;THR A 351;THR B  86;HIS B  53","None","1.24A","2zj0B-4ci0A:undetectable","2zj0B-4ci0A:21.69"],["3EEY_D_SAMD300_0","PUTATIVE RRNA METHYLASE","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT GAMMA","Methanothermobacter marburgensis",5,"GLY B 207;ILE B 254;GLY B 170;LEU B 235;THR B 232","SF4 B1275 ( 4.0A);SF4 B1275 ( 4.6A);None;SF4 B1275 (-3.7A);SF4 B1275 (-3.4A)","1.18A","3eeyD-4ci0B:undetectable","3eeyD-4ci0B:20.00"],["3EEY_J_SAMJ300_0","PUTATIVE RRNA METHYLASE","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT GAMMA","Methanothermobacter marburgensis",5,"GLY B 207;ILE B 254;GLY B 170;LEU B 235;THR B 232","SF4 B1275 ( 4.0A);SF4 B1275 ( 4.6A);None;SF4 B1275 (-3.7A);SF4 B1275 (-3.4A)","1.12A","3eeyJ-4ci0B:undetectable","3eeyJ-4ci0B:20.00"],["3FL9_C_TOPC200_1","DIHYDROFOLATE REDUCTASE (DHFR)","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT BETA;F420-REDUCING HYDROGENASE, SUBUNIT GAMMA","Methanothermobacter marburgensis",5,"ALA C 101;ASN C 137;VAL C  82;ILE B 221;THR C  99","None;SF4 C1282 ( 3.7A);None;SF4 C1282 ( 3.6A);None","1.34A","3fl9C-4ci0C:undetectable","3fl9C-4ci0C:20.89"],["3FL9_E_TOPE200_1","DIHYDROFOLATE REDUCTASE (DHFR)","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT GAMMA","Methanothermobacter marburgensis",5,"LEU B 100;LEU B  64;ILE B  81;LEU B  75;THR B 181","None","1.10A","3fl9E-4ci0B:undetectable","3fl9E-4ci0B:19.64"],["3J6P_B_TA1B502_1","TUBULIN BETA CHAIN","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT ALPHA","Methanothermobacter marburgensis",5,"GLU A 325;LEU A 319;SER A 212;PHE A 222;LEU A 348","None","1.02A","3j6pB-4ci0A:undetectable","3j6pB-4ci0A:20.82"],["3K13_C_THHC643_1","5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE METHYLTRANSFERASE","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT ALPHA;F420-REDUCING HYDROGENASE, SUBUNIT GAMMA","Methanothermobacter marburgensis;Methanothermobacter marburgensis",3,"ASN B 245;ASP B 236;ARG A  94","None","0.88A","3k13C-4ci0B:undetectable","3k13C-4ci0B:22.88"],["3N2O_C_AG2C1002_1","BIOSYNTHETIC ARGININE DECARBOXYLASE;BIOSYNTHETIC ARGININE DECARBOXYLASE","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT BETA","Methanothermobacter marburgensis",4,"SER C  65;ASP C  16;LEU C 238;ASP C  38","None","0.99A","3n2oC-4ci0C:undetectable;3n2oD-4ci0C:undetectable","3n2oC-4ci0C:19.17;3n2oD-4ci0C:19.17"],["3OKX_A_SAMA201_0","YAEB-LIKE PROTEIN RPA0152","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT BETA","Methanothermobacter marburgensis",5,"LEU C 253;TYR C 133;GLY C 208;THR C 207;SER C 206","None;None;FAD C1283 (-3.6A);FAD C1283 (-4.6A);None","1.26A","3okxA-4ci0C:undetectable","3okxA-4ci0C:20.85"],["3OKX_A_SAMA201_0","YAEB-LIKE PROTEIN RPA0152","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT BETA","Methanothermobacter marburgensis",5,"LEU C 253;TYR C 133;THR C 207;SER C 206;LEU C 257","None;None;FAD C1283 (-4.6A);None;None","1.38A","3okxA-4ci0C:undetectable","3okxA-4ci0C:20.85"],["3OKX_B_SAMB201_1","YAEB-LIKE PROTEIN RPA0152","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT BETA","Methanothermobacter marburgensis",5,"LEU C 253;TYR C 133;GLY C 208;THR C 207;LEU C 257","None;None;FAD C1283 (-3.6A);FAD C1283 (-4.6A);None","1.19A","3okxB-4ci0C:undetectable","3okxB-4ci0C:20.85"],["3OKX_B_SAMB201_1","YAEB-LIKE PROTEIN RPA0152","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT BETA","Methanothermobacter marburgensis",5,"LEU C 253;TYR C 133;GLY C 208;THR C 207;SER C 206","None;None;FAD C1283 (-3.6A);FAD C1283 (-4.6A);None","1.26A","3okxB-4ci0C:undetectable","3okxB-4ci0C:20.85"],["3QEL_B_QELB1_1","NMDA GLUTAMATE RECEPTOR SUBUNIT;GLUTAMATE [NMDA] RECEPTOR SUBUNIT EPSILON-2","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT ALPHA;F420-REDUCING HYDROGENASE, SUBUNIT GAMMA","Methanothermobacter marburgensis",5,"TYR B  68;ALA A 107;ILE A 133;THR B  58;GLU A  14","None","1.28A","3qelA-4ci0B:undetectable;3qelB-4ci0B:undetectable","3qelA-4ci0B:21.59;3qelB-4ci0B:22.43"],["3TBG_A_RTZA2_1","CYTOCHROME P450 2D6","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT ALPHA;F420-REDUCING HYDROGENASE, SUBUNIT GAMMA","Methanothermobacter marburgensis",5,"THR A 351;VAL A 349;LEU A  43;VAL A  40;PHE B 138","None","1.32A","3tbgA-4ci0A:0.7","3tbgA-4ci0A:24.05"],["3TBG_A_RTZA2_1","CYTOCHROME P450 2D6","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT ALPHA;F420-REDUCING HYDROGENASE, SUBUNIT GAMMA","Methanothermobacter marburgensis",5,"VAL A 349;LEU A  43;VAL A  40;THR A 385;PHE B 138","None","1.38A","3tbgA-4ci0A:0.7","3tbgA-4ci0A:24.05"],["3TBG_C_RTZC2_1","CYTOCHROME P450 2D6","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT ALPHA;F420-REDUCING HYDROGENASE, SUBUNIT GAMMA","Methanothermobacter marburgensis",5,"THR A 351;VAL A 349;LEU A  43;VAL A  40;PHE B 138","None","1.38A","3tbgC-4ci0A:undetectable","3tbgC-4ci0A:24.05"],["3TBG_C_RTZC2_1","CYTOCHROME P450 2D6","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT ALPHA;F420-REDUCING HYDROGENASE, SUBUNIT GAMMA","Methanothermobacter marburgensis",5,"VAL A 349;LEU A  43;VAL A  40;THR A 385;PHE B 138","None","1.39A","3tbgC-4ci0A:undetectable","3tbgC-4ci0A:24.05"],["3UR0_C_SVRC516_1","RNA-DEPENDENT RNA POLYMERASE","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT ALPHA","Methanothermobacter marburgensis",5,"PRO A 327;GLY A 329;ALA A 326;ALA A  73;LEU A  98","None;None; FE A1387 ( 3.9A);None;None","1.48A","3ur0C-4ci0A:undetectable","3ur0C-4ci0A:21.54"],["4B9Z_A_ACRA1818_1","ALPHA-GLUCOSIDASE, PUTATIVE, ADG31B","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT ALPHA","Methanothermobacter marburgensis",5,"LEU A 224;ILE A 321;LEU A 348;GLU A 229;PHE A 344","None;None;None;FE2 A1389 ( 4.3A);None","1.46A","4b9zA-4ci0A:undetectable","4b9zA-4ci0A:20.96"],["4EJJ_D_NCTD501_1","CYTOCHROME P450 2A6","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT BETA","Methanothermobacter marburgensis",4,"GLY C 211;THR C 218;ILE C 220;LEU C   3","None","0.84A","4ejjD-4ci0C:undetectable","4ejjD-4ci0C:20.97"],["4IIL_A_RBFA401_2","MEMBRANE LIPOPROTEIN TPN38(B)","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT ALPHA","Methanothermobacter marburgensis",4,"VAL A 140;ASN A 136;GLN A 177;ILE A 295","None","0.99A","4iilA-4ci0A:undetectable","4iilA-4ci0A:24.07"],["4IK7_A_IMNA201_1","TRANSTHYRETIN","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT BETA","Methanothermobacter marburgensis",4,"LEU C 128;THR C 207;THR C 221;VAL C 219","None;FAD C1283 (-4.6A);None;None","0.66A","4ik7A-4ci0C:undetectable","4ik7A-4ci0C:19.49"],["4IK7_B_IMNB201_1","TRANSTHYRETIN","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT BETA","Methanothermobacter marburgensis",4,"LEU C 128;THR C 207;THR C 221;VAL C 219","None;FAD C1283 (-4.6A);None;None","0.57A","4ik7B-4ci0C:undetectable","4ik7B-4ci0C:19.49"],["4MK4_A_CHDA504_0","FERROCHELATASE, MITOCHONDRIAL","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT ALPHA;F420-REDUCING HYDROGENASE, SUBUNIT BETA","Methanothermobacter marburgensis;Methanothermobacter marburgensis",4,"SER A 152;ARG A 155;VAL C 119;GLY C 118","None","0.97A","4mk4A-4ci0A:undetectable","4mk4A-4ci0A:20.63"],["4RJD_B_TFPB204_1","CALMODULIN;CALMODULIN","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT ALPHA","Methanothermobacter marburgensis",4,"LEU A 330;GLY A 329;GLU A 286;ALA A 282","None","0.62A","4rjdA-4ci0A:undetectable;4rjdB-4ci0A:undetectable","4rjdA-4ci0A:13.79;4rjdB-4ci0A:13.79"],["4RP8_C_ASCC501_0","ASCORBATE-SPECIFIC PERMEASE IIC COMPONENT ULAA","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT GAMMA","Methanothermobacter marburgensis",5,"LEU B 199;ILE B 254;GLN B 258;ALA B 134;ILE B 177","None;SF4 B1275 ( 4.6A);None;None;None","1.21A","4rp8C-4ci0B:undetectable","4rp8C-4ci0B:18.67"],["4W5O_A_IPHA907_0","PROTEIN ARGONAUTE-2","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT GAMMA","Methanothermobacter marburgensis",4,"ALA B 167;THR B 135;THR B 203;TYR B 202","None","1.36A","4w5oA-4ci0B:2.1","4w5oA-4ci0B:16.84"],["4W5Q_A_IPHA905_0","PROTEIN ARGONAUTE-2","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT GAMMA","Methanothermobacter marburgensis",4,"ALA B 167;THR B 135;THR B 203;TYR B 202","None","1.35A","4w5qA-4ci0B:undetectable","4w5qA-4ci0B:16.84"],["4W5R_A_IPHA905_0","PROTEIN ARGONAUTE-2","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT GAMMA","Methanothermobacter marburgensis",4,"ALA B 167;THR B 135;THR B 203;TYR B 202","None","1.34A","4w5rA-4ci0B:undetectable","4w5rA-4ci0B:16.84"],["4W5T_A_IPHA905_0","PROTEIN ARGONAUTE-2","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT GAMMA","Methanothermobacter marburgensis",4,"ALA B 167;THR B 135;THR B 203;TYR B 202","None","1.34A","4w5tA-4ci0B:2.5","4w5tA-4ci0B:16.84"],["4XE3_B_CL6B502_1","CYTOCHROME P-450","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT BETA","Methanothermobacter marburgensis",4,"LEU C 128;ALA C 203;VAL C 219;ILE C 220","None","0.97A","4xe3B-4ci0C:undetectable","4xe3B-4ci0C:21.77"],["4Z4C_A_IPHA906_0","PROTEIN ARGONAUTE-2","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT GAMMA","Methanothermobacter marburgensis",4,"ALA B 167;THR B 135;THR B 203;TYR B 202","None","1.36A","4z4cA-4ci0B:undetectable","4z4cA-4ci0B:16.84"],["4Z4D_A_IPHA905_0","PROTEIN ARGONAUTE-2","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT GAMMA","Methanothermobacter marburgensis",4,"ALA B 167;THR B 135;THR B 203;TYR B 202","None","1.36A","4z4dA-4ci0B:undetectable","4z4dA-4ci0B:16.84"],["4Z4E_A_IPHA907_0","PROTEIN ARGONAUTE-2","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT GAMMA","Methanothermobacter marburgensis",4,"ALA B 167;THR B 135;THR B 203;TYR B 202","None","1.36A","4z4eA-4ci0B:1.9","4z4eA-4ci0B:16.84"],["4Z4F_A_IPHA904_0","PROTEIN ARGONAUTE-2","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT GAMMA","Methanothermobacter marburgensis",4,"ALA B 167;THR B 135;THR B 203;TYR B 202","None","1.36A","4z4fA-4ci0B:2.4","4z4fA-4ci0B:16.84"],["4Z4G_A_IPHA905_0","PROTEIN ARGONAUTE-2","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT GAMMA","Methanothermobacter marburgensis",4,"ALA B 167;THR B 135;THR B 203;TYR B 202","None","1.35A","4z4gA-4ci0B:2.5","4z4gA-4ci0B:16.84"],["4Z4I_A_IPHA904_0","PROTEIN ARGONAUTE-2","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT GAMMA","Methanothermobacter marburgensis",4,"ALA B 167;THR B 135;THR B 203;TYR B 202","None","1.34A","4z4iA-4ci0B:2.5","4z4iA-4ci0B:16.84"],["4ZO1_X_T3X500_1","THYROID HORMONE RECEPTOR BETA","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT ALPHA","Methanothermobacter marburgensis",5,"ILE A 133;ALA A 137;ALA A 290;LEU A 291;HIS A 110","None","1.49A","4zo1X-4ci0A:undetectable","4zo1X-4ci0A:22.19"],["5B8I_C_FK5C201_2","CALCINEURIN SUBUNIT B, VARIANT;PEPTIDYL-PROLYL CIS-TRANS ISOMERASE","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT ALPHA","Methanothermobacter marburgensis",4,"LEU A 291;MET A 287;VAL A 103;ASN A 104","None","1.27A","5b8iB-4ci0A:0.2","5b8iB-4ci0A:19.74"],["5CP4_A_CAMA422_0","CYTOCHROME P450CAM","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT BETA","Methanothermobacter marburgensis",5,"THR C 207;LEU C  33;VAL C  29;GLY C  31;VAL C 219","FAD C1283 (-4.6A);None;FAD C1283 (-4.0A);None;None","1.31A","5cp4A-4ci0C:undetectable","5cp4A-4ci0C:20.88"],["5EWJ_D_QELD503_1","NMDA GLUTAMATE RECEPTOR SUBUNIT;GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT ALPHA;F420-REDUCING HYDROGENASE, SUBUNIT GAMMA","Methanothermobacter marburgensis",5,"TYR B  68;ALA A 107;ILE A 133;THR B  58;GLU A  14","None","1.30A","5ewjC-4ci0B:2.3;5ewjD-4ci0B:2.5","5ewjC-4ci0B:21.57;5ewjD-4ci0B:22.43"],["5HWA_A_GCSA303_1","CHITOSANASE","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT ALPHA","Methanothermobacter marburgensis",4,"HIS A 150;VAL A 141;GLY A 146;ALA A 145","SF4 B1274 ( 4.4A);None;None;None","0.95A","5hwaA-4ci0A:1.7","5hwaA-4ci0A:20.26"],["5IEP_A_VDYA201_2","CDL2.3B","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT GAMMA","Methanothermobacter marburgensis",5,"ILE B 178;PRO B 175;VAL B 257;ILE B 254;LEU B 100","None;None;None;SF4 B1275 ( 4.6A);None","1.46A","5iepA-4ci0B:undetectable","5iepA-4ci0B:19.93"],["5J2T_C_VLBC503_2","TUBULIN ALPHA-1B CHAIN","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT BETA","Methanothermobacter marburgensis",5,"VAL C  29;ALA C  34;VAL C 130;GLY C 131;ILE C 132","FAD C1283 (-4.0A);None;None;None;FAD C1283 (-3.6A)","0.79A","5j2tC-4ci0C:undetectable","5j2tC-4ci0C:20.58"],["5JHD_E_EDTE301_0","BETA-2-MICROGLOBULIN;TCRBETA CHAIN","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT ALPHA","Methanothermobacter marburgensis",4,"TYR A  34;SER A  36;THR A 385;PRO A   9","None","1.11A","5jhdE-4ci0A:undetectable;5jhdG-4ci0A:undetectable","5jhdE-4ci0A:20.05;5jhdG-4ci0A:16.42"],["5JMN_C_FUAC1101_1","MULTIDRUG EFFLUX PUMP SUBUNIT ACRB","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT ALPHA","Methanothermobacter marburgensis",3,"VAL A 154;HIS A  70;VAL A  59","None; FE A1387 ( 4.6A);None","0.68A","5jmnC-4ci0A:undetectable","5jmnC-4ci0A:18.28"],["5NFP_A_8W5A804_2","GLUCOCORTICOID RECEPTOR","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT ALPHA","Methanothermobacter marburgensis",4,"LEU A  96;MET A 159;ILE A 215;LEU A  72","None","1.29A","5nfpA-4ci0A:undetectable","5nfpA-4ci0A:19.34"],["5NNA_A_BZMA301_0","ISATIN HYDROLASE A","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT BETA","Methanothermobacter marburgensis",5,"ILE C 220;LEU C   3;SER C 212;GLY C 208;GLY C 211","None;None;None;FAD C1283 (-3.6A);None","1.12A","5nnaA-4ci0C:undetectable","5nnaA-4ci0C:21.04"],["5NNA_B_BZMB301_0","ISATIN HYDROLASE A","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT BETA","Methanothermobacter marburgensis",5,"ILE C 220;LEU C   3;SER C 212;GLY C 208;GLY C 211","None;None;None;FAD C1283 (-3.6A);None","1.13A","5nnaB-4ci0C:undetectable","5nnaB-4ci0C:21.04"],["5NNA_C_BZMC301_0","ISATIN HYDROLASE A","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT BETA","Methanothermobacter marburgensis",5,"ILE C 220;LEU C   3;SER C 212;GLY C 208;GLY C 211","None;None;None;FAD C1283 (-3.6A);None","1.12A","5nnaC-4ci0C:undetectable","5nnaC-4ci0C:21.04"],["5NNA_D_BZMD301_0","ISATIN HYDROLASE A","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT BETA","Methanothermobacter marburgensis",5,"ILE C 220;LEU C   3;SER C 212;GLY C 208;GLY C 211","None;None;None;FAD C1283 (-3.6A);None","1.11A","5nnaD-4ci0C:undetectable","5nnaD-4ci0C:21.04"],["5VOO_F_C2FF3001_0","5-METHYLTETRAHYDROFOLATE HOMOCYSTEINE S-METHYLTRANSFERASE","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT BETA","Methanothermobacter marburgensis",5,"GLY C 226;LEU C  68;GLY C  98;ARG C 110;ILE C  42","None","1.11A","5vooF-4ci0C:undetectable","5vooF-4ci0C:25.61"],["5VOP_B_C2FB3001_0","5-METHYLTETRAHYDROFOLATE HOMOCYSTEINE S-METHYLTRANSFERASE","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT BETA","Methanothermobacter marburgensis",5,"GLY C 226;LEU C  68;GLY C  98;ARG C 110;ILE C  42","None","1.15A","5vopB-4ci0C:undetectable","5vopB-4ci0C:25.61"],["6A5Y_D_9CRD501_1","RETINOIC ACID RECEPTOR RXR-ALPHA","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT ALPHA","Methanothermobacter marburgensis",3,"ASN A 104;VAL A 186;HIS A 185","None","0.79A","6a5yD-4ci0A:undetectable","6a5yD-4ci0A:13.28"],["6EF6_A_ACTA405_0","AMINOGLYCOSIDE PHOSPHOTRANSFERASE","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT ALPHA;F420-REDUCING HYDROGENASE, SUBUNIT GAMMA;F420-REDUCING HYDROGENASE, SUBUNIT BETA","Methanothermobacter marburgensis;Methanothermobacter marburgensis;Methanothermobacter marburgensis",4,"ARG A 134;PRO B 175;ARG C 120;ILE A 149","None","1.34A","6ef6A-4ci0A:undetectable","6ef6A-4ci0A:22.92"],["6EQP_A_BUWA601_1","CHOLINESTERASE","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT ALPHA","Methanothermobacter marburgensis",4,"GLY A 275;GLN A 279;PHE A 365;TYR A 369","None","1.01A","6eqpA-4ci0A:undetectable","6eqpA-4ci0A:12.34"],["6EXI_D_ADND502_1","ADENOSYLHOMOCYSTEINASE","4ci0","F420-REDUCING HYDROGENASE, SUBUNIT GAMMA","Methanothermobacter marburgensis",3,"LEU B 100;ASN B  67;LEU B  75","None","0.67A","6exiD-4ci0B:undetectable","6exiD-4ci0B:14.96"]]