SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ci7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_C_RABC647_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4ci7 CELL SURFACE PROTEIN
(PUTATIVE CELL
SURFACE-ASSOCIATED
CYSTEINE PROTEASE)
(Clostridioides
difficile) 		5 / 9 MET A 336
VAL A 414
SER A 326
ASP A 212
ILE A 412
 None
 1.42A 1pw7C-4ci7A:
undetectable		 1pw7C-4ci7A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_B_FK5B401_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 4ci7 CELL SURFACE PROTEIN
(PUTATIVE CELL
SURFACE-ASSOCIATED
CYSTEINE PROTEASE)
(Clostridioides
difficile) 		5 / 10 ARG A 215
VAL A  66
ILE A  67
TYR A 454
ILE A 451
 None
 1.33A 1q6iB-4ci7A:
undetectable		 1q6iB-4ci7A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 4ci7 CELL SURFACE PROTEIN
(PUTATIVE CELL
SURFACE-ASSOCIATED
CYSTEINE PROTEASE)
(Clostridioides
difficile) 		6 / 10 GLN A 110
TRP A 117
PHE A 119
SER A 120
HIS A 262
ALA A 263
 None
 0.69A 1stfE-4ci7A:
21.4
1stfI-4ci7A:
undetectable		 1stfE-4ci7A:
19.53
1stfI-4ci7A:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4ci7 CELL SURFACE PROTEIN
(PUTATIVE CELL
SURFACE-ASSOCIATED
CYSTEINE PROTEASE)
(Clostridioides
difficile) 		4 / 7 ALA A 265
SER A 120
SER A 235
ASN A 165
 None
 1.01A 2i91A-4ci7A:
undetectable		 2i91A-4ci7A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4ci7 CELL SURFACE PROTEIN
(PUTATIVE CELL
SURFACE-ASSOCIATED
CYSTEINE PROTEASE)
(Clostridioides
difficile) 		4 / 7 ALA A 265
SER A 120
SER A 235
ASN A 165
 None
 1.01A 2i91B-4ci7A:
undetectable		 2i91B-4ci7A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4ci7 CELL SURFACE PROTEIN
(PUTATIVE CELL
SURFACE-ASSOCIATED
CYSTEINE PROTEASE)
(Clostridioides
difficile) 		4 / 7 ILE A 451
SER A 164
TYR A  51
TYR A 455
 None
 1.41A 2xz5D-4ci7A:
undetectable
2xz5E-4ci7A:
undetectable		 2xz5D-4ci7A:
19.33
2xz5E-4ci7A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_B_HNQB255_1
(CATHEPSIN B)		 4ci7 CELL SURFACE PROTEIN
(PUTATIVE CELL
SURFACE-ASSOCIATED
CYSTEINE PROTEASE)
(Clostridioides
difficile) 		4 / 6 GLN A 110
GLY A 111
HIS A 262
HIS A 239
 None
 1.43A 3ai8B-4ci7A:
19.8		 3ai8B-4ci7A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 4ci7 CELL SURFACE PROTEIN
(PUTATIVE CELL
SURFACE-ASSOCIATED
CYSTEINE PROTEASE)
(Clostridioides
difficile) 		4 / 8 SER A  45
LEU A 260
ASP A 318
ASP A 320
 None
 1.22A 3n2oC-4ci7A:
undetectable
3n2oD-4ci7A:
undetectable		 3n2oC-4ci7A:
21.72
3n2oD-4ci7A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4ci7 CELL SURFACE PROTEIN
(PUTATIVE CELL
SURFACE-ASSOCIATED
CYSTEINE PROTEASE)
(Clostridioides
difficile) 		5 / 12 TYR A 322
GLY A 121
ALA A 265
SER A 235
ALA A 168
 None
 1.18A 3nmuA-4ci7A:
undetectable
3nmuF-4ci7A:
undetectable		 3nmuA-4ci7A:
22.04
3nmuF-4ci7A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4ci7 CELL SURFACE PROTEIN
(PUTATIVE CELL
SURFACE-ASSOCIATED
CYSTEINE PROTEASE)
(Clostridioides
difficile) 		4 / 5 VAL A 489
PHE A 358
ILE A 428
PHE A 360
 None
 1.07A 3owxB-4ci7A:
undetectable		 3owxB-4ci7A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4ci7 CELL SURFACE PROTEIN
(PUTATIVE CELL
SURFACE-ASSOCIATED
CYSTEINE PROTEASE)
(Clostridioides
difficile) 		3 / 3 TYR A 454
GLU A 340
TYR A 341
 None
 0.82A 3ug8A-4ci7A:
undetectable		 3ug8A-4ci7A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQA_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4ci7 CELL SURFACE PROTEIN
(PUTATIVE CELL
SURFACE-ASSOCIATED
CYSTEINE PROTEASE)
(Clostridioides
difficile) 		5 / 10 ARG A 215
VAL A  66
ILE A  67
TYR A 454
ILE A 451
 None
 1.45A 3uqaA-4ci7A:
undetectable		 3uqaA-4ci7A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 4ci7 CELL SURFACE PROTEIN
(PUTATIVE CELL
SURFACE-ASSOCIATED
CYSTEINE PROTEASE)
(Clostridioides
difficile) 		4 / 8 ASN A 165
ASN A 114
THR A 115
TRP A 117
 None
PGE  A1508 (-4.0A)
None
None
 0.78A 4d1yA-4ci7A:
undetectable
4d1yB-4ci7A:
undetectable		 4d1yA-4ci7A:
17.83
4d1yB-4ci7A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 4ci7 CELL SURFACE PROTEIN
(PUTATIVE CELL
SURFACE-ASSOCIATED
CYSTEINE PROTEASE)
(Clostridioides
difficile) 		5 / 11 SER A 443
VAL A 430
LEU A 445
THR A 444
VAL A 383
 None
 1.16A 4e0fA-4ci7A:
undetectable		 4e0fA-4ci7A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4ci7 CELL SURFACE PROTEIN
(PUTATIVE CELL
SURFACE-ASSOCIATED
CYSTEINE PROTEASE)
(Clostridioides
difficile) 		3 / 3 ALA A 446
TYR A 447
PRO A  70
 None
 0.57A 4zdyA-4ci7A:
undetectable		 4zdyA-4ci7A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OCS_A_ACTA402_0
(PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE)		 4ci7 CELL SURFACE PROTEIN
(PUTATIVE CELL
SURFACE-ASSOCIATED
CYSTEINE PROTEASE)
(Clostridioides
difficile) 		4 / 5 ILE A 308
HIS A 239
HIS A 262
TYR A 237
 None
 1.42A 5ocsA-4ci7A:
undetectable		 5ocsA-4ci7A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OCS_C_ACTC402_0
(PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE)		 4ci7 CELL SURFACE PROTEIN
(PUTATIVE CELL
SURFACE-ASSOCIATED
CYSTEINE PROTEASE)
(Clostridioides
difficile) 		4 / 5 ILE A 308
HIS A 239
HIS A 262
TYR A 237
 None
 1.41A 5ocsC-4ci7A:
undetectable		 5ocsC-4ci7A:
19.84