SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ci8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		4 / 7 THR A 246
TYR A 248
TRP A 225
GLN A 262
 None
 1.36A 1eiiA-4ci8A:
undetectable		 1eiiA-4ci8A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		4 / 6 GLN A 264
TYR A 248
VAL A 526
GLY A 228
 None
 1.26A 1ekjC-4ci8A:
undetectable
1ekjD-4ci8A:
undetectable		 1ekjC-4ci8A:
17.88
1ekjD-4ci8A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		5 / 8 ASP A 647
SER A 645
GLN A 588
GLY A 606
GLY A 625
 None
 1.26A 1f5lA-4ci8A:
undetectable		 1f5lA-4ci8A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		5 / 9 GLY A 289
HIS A 270
HIS A 304
THR A 288
ILE A 331
 None
 1.48A 1gtnG-4ci8A:
undetectable
1gtnH-4ci8A:
undetectable		 1gtnG-4ci8A:
9.19
1gtnH-4ci8A:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		4 / 7 SER A 310
ASP A 309
GLU A 245
GLU A 261
 None
 1.20A 1knyA-4ci8A:
undetectable
1knyB-4ci8A:
undetectable		 1knyA-4ci8A:
16.26
1knyB-4ci8A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		4 / 4 LEU A 405
VAL A 355
CYH A 343
ALA A 332
 None
 1.28A 1mz9E-4ci8A:
undetectable		 1mz9E-4ci8A:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA502_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		5 / 9 TYR A 267
HIS A 270
GLY A 269
LEU A 256
ILE A 286
 None
 1.40A 1oltA-4ci8A:
0.0		 1oltA-4ci8A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_A_IPHA6012_0
(PHENOL
2-MONOOXYGENASE)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		5 / 10 ASP A 624
GLY A 625
MET A 632
ILE A 643
GLY A 606
 None
 1.38A 1pn0A-4ci8A:
undetectable		 1pn0A-4ci8A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_B_IPHB6022_0
(PHENOL
2-MONOOXYGENASE)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		5 / 10 ASP A 624
GLY A 625
MET A 632
ILE A 643
GLY A 606
 None
 1.40A 1pn0B-4ci8A:
undetectable		 1pn0B-4ci8A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_B_BEZB882_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		5 / 12 LEU A 342
GLY A 289
ILE A 307
HIS A 270
HIS A 304
 None
 1.44A 1tmxB-4ci8A:
undetectable		 1tmxB-4ci8A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_B_BEZB882_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		5 / 12 LEU A 342
GLY A 289
TYR A 267
HIS A 270
HIS A 304
 None
 1.43A 1tmxB-4ci8A:
undetectable		 1tmxB-4ci8A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		4 / 7 SER A 684
PRO A 594
HIS A 593
GLY A 654
 None
 1.05A 2ddwB-4ci8A:
undetectable		 2ddwB-4ci8A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		5 / 12 ILE A 506
GLY A 479
GLY A 461
GLY A 504
ILE A 463
 None
None
None
SO4  A1821 ( 4.6A)
None
 0.94A 2fk8A-4ci8A:
undetectable		 2fk8A-4ci8A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1100_1
(SERUM ALBUMIN)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		4 / 6 HIS A 351
TYR A 396
GLY A 391
LYS A 392
 None
 1.22A 2i30A-4ci8A:
undetectable		 2i30A-4ci8A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		3 / 3 THR A 676
ASP A 759
SER A 785
 None
 0.71A 2nxeA-4ci8A:
undetectable		 2nxeA-4ci8A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		3 / 3 THR A 676
ASP A 759
SER A 785
 None
 0.78A 2nxeB-4ci8A:
undetectable		 2nxeB-4ci8A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		4 / 6 THR A 676
THR A 724
ASP A 679
THR A 720
 None
 1.29A 2okcB-4ci8A:
undetectable		 2okcB-4ci8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		5 / 12 ILE A 551
ALA A 572
VAL A 787
LEU A 549
LEU A 221
 None
 1.29A 2rctA-4ci8A:
undetectable		 2rctA-4ci8A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		5 / 8 ASP A 647
SER A 645
GLN A 588
GLY A 606
GLY A 625
 None
 1.39A 2vinA-4ci8A:
undetectable		 2vinA-4ci8A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_C_CTCC1385_0
(TETX2 PROTEIN)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		5 / 12 PHE A 464
HIS A 459
GLY A 462
PRO A 505
GLY A 520
 None
 1.39A 2y6rC-4ci8A:
undetectable		 2y6rC-4ci8A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		4 / 6 GLY A 529
ILE A 517
ILE A 519
ASP A 534
 None
 0.89A 3a7eA-4ci8A:
undetectable		 3a7eA-4ci8A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		4 / 8 LEU A 678
ILE A 675
HIS A 671
GLY A 692
 None
 0.92A 3b9lA-4ci8A:
undetectable		 3b9lA-4ci8A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		4 / 5 PRO A 418
VAL A 421
THR A 448
GLY A 445
 None
 1.21A 3elzB-4ci8A:
undetectable		 3elzB-4ci8A:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		4 / 8 GLY A 782
VAL A 253
VAL A 763
VAL A 787
 None
 0.76A 3fi0B-4ci8A:
undetectable		 3fi0B-4ci8A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		4 / 8 GLY A 782
VAL A 253
VAL A 763
VAL A 787
 None
 0.77A 3fi0G-4ci8A:
undetectable		 3fi0G-4ci8A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		5 / 10 VAL A 279
LEU A 256
VAL A 254
VAL A 247
LEU A 241
 None
 0.91A 3gwxA-4ci8A:
undetectable		 3gwxA-4ci8A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		4 / 4 PRO A 505
THR A 521
GLY A 529
THR A 530
 None
 1.17A 3ib1A-4ci8A:
undetectable		 3ib1A-4ci8A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		5 / 12 VAL A 787
GLY A 757
PHE A 766
LEU A 765
TYR A 780
 None
None
None
None
SO4  A1819 (-4.1A)
 1.24A 3medA-4ci8A:
undetectable
3medB-4ci8A:
undetectable		 3medA-4ci8A:
21.86
3medB-4ci8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		4 / 5 ILE A 809
THR A 560
THR A 568
PHE A 558
 None
 1.08A 3snfA-4ci8A:
undetectable		 3snfA-4ci8A:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_A_MIYA2001_1
(TETX2 PROTEIN)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		5 / 11 PHE A 464
HIS A 459
GLY A 462
PRO A 505
GLY A 520
 None
 1.45A 3v3nA-4ci8A:
undetectable		 3v3nA-4ci8A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		5 / 11 PHE A 464
HIS A 459
GLY A 462
PRO A 505
GLY A 520
 None
 1.47A 3v3oC-4ci8A:
undetectable		 3v3oC-4ci8A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_B_MIYB391_1
(TETX2 PROTEIN)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		5 / 11 PHE A 464
HIS A 459
GLY A 462
PRO A 505
GLY A 520
 None
 1.45A 4a99B-4ci8A:
undetectable		 4a99B-4ci8A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		4 / 6 ILE A 463
VAL A 475
LEU A 469
CYH A 467
 None
 0.93A 4asdA-4ci8A:
undetectable		 4asdA-4ci8A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		5 / 12 HIS A 783
GLY A 757
SER A 755
HIS A 786
GLY A 782
 None
 1.24A 4blvB-4ci8A:
undetectable		 4blvB-4ci8A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		4 / 7 THR A 560
ILE A 809
THR A 807
GLY A 804
 None
 0.97A 4eq4A-4ci8A:
undetectable		 4eq4A-4ci8A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		4 / 7 THR A 560
ILE A 809
THR A 807
GLY A 804
 None
 0.94A 4eqlA-4ci8A:
undetectable		 4eqlA-4ci8A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		4 / 7 THR A 560
ILE A 809
THR A 807
GLY A 804
 None
 0.93A 4eqlB-4ci8A:
undetectable		 4eqlB-4ci8A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		5 / 12 ILE A 551
ALA A 572
VAL A 787
LEU A 549
LEU A 221
 None
 1.33A 4qynA-4ci8A:
2.7		 4qynA-4ci8A:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		4 / 6 TRP A 547
GLY A 803
THR A 802
VAL A 787
 None
 0.92A 5ewuA-4ci8A:
undetectable		 5ewuA-4ci8A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		4 / 6 TRP A 547
GLY A 803
THR A 802
VAL A 787
 None
 1.06A 5ewuB-4ci8A:
undetectable		 5ewuB-4ci8A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		4 / 6 TRP A 608
GLY A 602
THR A 603
VAL A 601
 None
 1.06A 5ewuB-4ci8A:
undetectable		 5ewuB-4ci8A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		4 / 8 TYR A 653
TRP A 608
THR A 623
LEU A 629
 None
None
SO4  A1818 (-4.4A)
None
 1.18A 5kxiA-4ci8A:
undetectable
5kxiB-4ci8A:
undetectable		 5kxiA-4ci8A:
20.15
5kxiB-4ci8A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		4 / 8 TYR A 653
TRP A 608
THR A 623
TYR A 651
 None
None
SO4  A1818 (-4.4A)
None
 1.39A 5kxiA-4ci8A:
undetectable
5kxiB-4ci8A:
undetectable		 5kxiA-4ci8A:
20.15
5kxiB-4ci8A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		4 / 8 TYR A 653
TRP A 608
THR A 623
LEU A 629
 None
None
SO4  A1818 (-4.4A)
None
 1.23A 5kxiD-4ci8A:
undetectable
5kxiE-4ci8A:
undetectable		 5kxiD-4ci8A:
20.15
5kxiE-4ci8A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		4 / 8 TYR A 653
TRP A 608
THR A 623
TYR A 651
 None
None
SO4  A1818 (-4.4A)
None
 1.41A 5kxiD-4ci8A:
undetectable
5kxiE-4ci8A:
undetectable		 5kxiD-4ci8A:
20.15
5kxiE-4ci8A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		5 / 12 PHE A 558
ILE A 800
LEU A 549
GLY A 228
LEU A 546
 None
 1.20A 5zwrA-4ci8A:
undetectable		 5zwrA-4ci8A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		4 / 6 PHE A 674
GLY A 692
THR A 676
TYR A 694
 None
 1.29A 6ag0A-4ci8A:
undetectable		 6ag0A-4ci8A:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		4 / 6 PHE A 674
GLY A 692
THR A 676
TYR A 694
 None
 1.23A 6ag0C-4ci8A:
undetectable		 6ag0C-4ci8A:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		3 / 3 ARG A 523
PHE A 503
GLY A 504
 SO4  A1821 (-4.0A)
None
SO4  A1821 ( 4.6A)
 0.79A 6fgdA-4ci8A:
undetectable		 6fgdA-4ci8A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		 4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens) 		5 / 10 THR A 788
GLY A 548
LEU A 549
SER A 784
TRP A 812
 None
 1.44A 6gnfC-4ci8A:
undetectable		 6gnfC-4ci8A:
22.10