SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cih'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AOW_A_THAA400_1 (HISTAMINE N-METHYLTRANSFERASE)	4cih	LISTERIA NUCLEAR TARGETED PROTEIN A (Listeria monocytogenes)	4 / 7	PHE A 74 GLU A 78 TYR A 173 GLU A 146	None	1.37A	2aowA-4cihA: undetectable	2aowA-4cihA: 21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DAU_A_MTXA201_1 (DIHYDROFOLATE REDUCTASE)	4cih	LISTERIA NUCLEAR TARGETED PROTEIN A (Listeria monocytogenes)	5 / 12	ILE A 118 LEU A 64 ALA A 65 LYS A 68 LEU A 191	None	0.90A	3dauA-4cihA: undetectable	3dauA-4cihA: 20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PSY_A_FOLA201_0 (DIHYDROFOLATE REDUCTASE)	4cih	LISTERIA NUCLEAR TARGETED PROTEIN A (Listeria monocytogenes)	5 / 12	ILE A 118 LEU A 64 ALA A 65 LYS A 68 LEU A 191	None	0.88A	4psyA-4cihA: undetectable	4psyA-4cihA: 20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5I1O_F_DVAF9_0 (D-VILLIN HEADPIECE SUBDOMAIN VILLIN-1)	4cih	LISTERIA NUCLEAR TARGETED PROTEIN A (Listeria monocytogenes)	3 / 3	ALA A 190 ASN A 193 LEU A 194	None	0.41A	5i1oC-4cihA: undetectable	5i1oC-4cihA: 11.89

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2AOW_A_THAA400_1","HISTAMINE N-METHYLTRANSFERASE","4cih","LISTERIA NUCLEAR TARGETED PROTEIN A","Listeria monocytogenes",4,"PHE A  74;GLU A  78;TYR A 173;GLU A 146","None","1.37A","2aowA-4cihA:undetectable","2aowA-4cihA:21.40"],["3DAU_A_MTXA201_1","DIHYDROFOLATE REDUCTASE","4cih","LISTERIA NUCLEAR TARGETED PROTEIN A","Listeria monocytogenes",5,"ILE A 118;LEU A  64;ALA A  65;LYS A  68;LEU A 191","None","0.90A","3dauA-4cihA:undetectable","3dauA-4cihA:20.36"],["4PSY_A_FOLA201_0","DIHYDROFOLATE REDUCTASE","4cih","LISTERIA NUCLEAR TARGETED PROTEIN A","Listeria monocytogenes",5,"ILE A 118;LEU A  64;ALA A  65;LYS A  68;LEU A 191","None","0.88A","4psyA-4cihA:undetectable","4psyA-4cihA:20.36"],["5I1O_F_DVAF9_0","D-VILLIN HEADPIECE SUBDOMAIN;VILLIN-1","4cih","LISTERIA NUCLEAR TARGETED PROTEIN A","Listeria monocytogenes",3,"ALA A 190;ASN A 193;LEU A 194","None","0.41A","5i1oC-4cihA:undetectable","5i1oC-4cihA:11.89"]]