SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cij'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1470_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 4cij GST REP
(Geobacillus
stearothermophil
us) 		4 / 5 ARG A 194
ALA A 118
ASP A 116
GLU A 196
 None
 1.12A 2xrzA-4cijA:
undetectable		 2xrzA-4cijA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 4cij GST REP
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 261
LEU A 226
GLY A 224
TYR A 229
ILE A 197
 None
 1.04A 3uwlB-4cijA:
undetectable		 3uwlB-4cijA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 4cij GST REP
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 261
LEU A 226
GLY A 224
TYR A 229
ILE A 197
 None
 1.03A 3uwlD-4cijA:
undetectable		 3uwlD-4cijA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4cij GST REP
(Geobacillus
stearothermophil
us) 		4 / 6 GLY A 157
GLY A 158
GLU A 156
ILE A 155
 None
 0.87A 4fglD-4cijA:
undetectable		 4fglD-4cijA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4cij GST REP
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A  65
VAL A  67
PHE A  33
PHE A  15
VAL A  13
 None
 1.23A 4nc3A-4cijA:
undetectable		 4nc3A-4cijA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4cij GST REP
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  76
LEU A  36
GLY A  85
THR A  82
THR A  14
 None
 1.16A 4ze2A-4cijA:
undetectable		 4ze2A-4cijA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4cij GST REP
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  76
LEU A  36
GLY A  85
THR A  82
THR A  14
 None
 1.12A 5eskA-4cijA:
undetectable		 5eskA-4cijA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4cij GST REP
(Geobacillus
stearothermophil
us) 		4 / 6 ASP A   9
GLN A  84
GLU A 196
THR A 164
 None
 1.40A 6djzA-4cijA:
undetectable		 6djzA-4cijA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 4cij GST REP
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 261
LEU A 226
GLY A 224
TYR A 229
ILE A 197
 None
 1.02A 6qxsB-4cijA:
undetectable		 6qxsB-4cijA:
21.25