SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cil'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4cil YOPM-CAP, INTERNALIN
B
(Listeria
monocytogenes;
Yersinia
enterocolitica) 		4 / 7 GLN A 240
SER A 216
LEU A 182
ILE A 220
 None
 1.02A 3ln1C-4cilA:
undetectable		 3ln1C-4cilA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 4cil YOPM-CAP, INTERNALIN
B
(Yersinia
enterocolitica;
Listeria
monocytogenes) 		3 / 3 SER A 192
GLY A 172
SER A 216
 None
 0.48A 3loqA-4cilA:
undetectable		 3loqA-4cilA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 4cil YOPM-CAP, INTERNALIN
B
(Listeria
monocytogenes;
Yersinia
enterocolitica) 		5 / 12 ASP A 134
LEU A 135
SER A 137
LEU A 149
ILE A 154
 None
 1.06A 4x1fA-4cilA:
undetectable		 4x1fA-4cilA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 4cil YOPM-CAP, INTERNALIN
B
(Listeria
monocytogenes;
Yersinia
enterocolitica) 		5 / 12 ASP A 134
LEU A 135
SER A 137
LEU A 149
ILE A 154
 None
 1.05A 4x1gA-4cilA:
undetectable		 4x1gA-4cilA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4cil YOPM-CAP, INTERNALIN
B
(Yersinia
enterocolitica;
Listeria
monocytogenes) 		5 / 10 LEU A 125
GLY A 123
LEU A 116
LEU A 119
THR A 101
 None
 1.07A 5o96G-4cilA:
undetectable
5o96H-4cilA:
undetectable		 5o96G-4cilA:
23.08
5o96H-4cilA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGJ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4cil YOPM-CAP, INTERNALIN
B
(Yersinia
enterocolitica;
Listeria
monocytogenes) 		3 / 3 VAL A 267
VAL A 259
GLN A 240
 None
 0.65A 5qgjA-4cilA:
undetectable		 5qgjA-4cilA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGM_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4cil YOPM-CAP, INTERNALIN
B
(Yersinia
enterocolitica;
Listeria
monocytogenes) 		3 / 3 VAL A 267
VAL A 259
GLN A 240
 None
 0.63A 5qgmA-4cilA:
undetectable		 5qgmA-4cilA:
19.86