SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cit'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4cit VANADIUM-DEPENDENT
HALOPEROXIDASE
(Zobellia
galactanivorans) 		5 / 11 THR A 295
SER A 297
PHE A 299
PHE A 399
VAL A 374
 None
 1.44A 1q23J-4citA:
undetectable		 1q23J-4citA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 4cit VANADIUM-DEPENDENT
HALOPEROXIDASE
(Zobellia
galactanivorans) 		6 / 12 ALA A 152
ALA A  64
LEU A 439
GLY A 156
TYR A  60
LEU A  83
 None
 1.43A 1qabF-4citA:
undetectable		 1qabF-4citA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 4cit VANADIUM-DEPENDENT
HALOPEROXIDASE
(Zobellia
galactanivorans) 		3 / 3 ASP A 153
GLU A 119
ARG A  56
 None
 0.80A 1wopA-4citA:
undetectable		 1wopA-4citA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_2
(PROTEASE)		 4cit VANADIUM-DEPENDENT
HALOPEROXIDASE
(Zobellia
galactanivorans) 		5 / 12 LEU A 371
ALA A 312
ASP A 315
VAL A 374
VAL A 370
 None
 0.79A 2ieoB-4citA:
undetectable		 2ieoB-4citA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_1
(PROTEASE)		 4cit VANADIUM-DEPENDENT
HALOPEROXIDASE
(Zobellia
galactanivorans) 		5 / 12 LEU A 371
ALA A 312
ASP A 315
VAL A 374
VAL A 370
 None
 0.86A 2nnkA-4citA:
undetectable		 2nnkA-4citA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4cit VANADIUM-DEPENDENT
HALOPEROXIDASE
(Zobellia
galactanivorans) 		4 / 5 LEU A 149
ALA A 152
LEU A 111
MET A 122
 None
 1.26A 2oaxA-4citA:
2.5		 2oaxA-4citA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 4cit VANADIUM-DEPENDENT
HALOPEROXIDASE
(Zobellia
galactanivorans) 		4 / 6 ALA A 104
LEU A 102
SER A 144
VAL A  69
 None
 1.00A 3d2tB-4citA:
undetectable		 3d2tB-4citA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 4cit VANADIUM-DEPENDENT
HALOPEROXIDASE
(Zobellia
galactanivorans) 		5 / 12 ASP A  38
ASP A 383
ILE A 290
ILE A 287
LYS A 276
 None
 1.43A 3phaB-4citA:
undetectable		 3phaB-4citA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 4cit VANADIUM-DEPENDENT
HALOPEROXIDASE
(Zobellia
galactanivorans) 		5 / 12 GLY A 424
ILE A 421
ALA A 407
ALA A 419
ARG A 418
 None
 1.13A 4kicA-4citA:
undetectable		 4kicA-4citA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDC_A_ASDA404_1
(3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE)		 4cit VANADIUM-DEPENDENT
HALOPEROXIDASE
(Zobellia
galactanivorans) 		5 / 12 VAL A 363
LEU A 439
ALA A 314
ASP A 315
LEU A 206
 None
 1.42A 4qdcA-4citA:
undetectable		 4qdcA-4citA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4cit VANADIUM-DEPENDENT
HALOPEROXIDASE
(Zobellia
galactanivorans) 		5 / 9 VAL A 205
LEU A 206
LEU A  83
GLY A 432
LEU A 439
 None
 1.09A 4rs0A-4citA:
undetectable		 4rs0A-4citA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4cit VANADIUM-DEPENDENT
HALOPEROXIDASE
(Zobellia
galactanivorans) 		4 / 5 PHE A 375
SER A 361
HIS A 360
ASP A 383
 None
None
VO4  A1451 ( 3.9A)
None
 1.27A 4rzvB-4citA:
undetectable		 4rzvB-4citA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 4cit VANADIUM-DEPENDENT
HALOPEROXIDASE
(Zobellia
galactanivorans) 		3 / 3 PRO A 262
ILE A 254
SER A  50
 OCS  A 260 ( 4.9A)
None
None
 0.80A 5fsaA-4citA:
undetectable		 5fsaA-4citA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_0
(PROTEASE)		 4cit VANADIUM-DEPENDENT
HALOPEROXIDASE
(Zobellia
galactanivorans) 		6 / 12 LEU A 371
ALA A 312
ASP A 315
VAL A 436
VAL A 374
VAL A 370
 None
 1.22A 6dh0A-4citA:
undetectable		 6dh0A-4citA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4cit VANADIUM-DEPENDENT
HALOPEROXIDASE
(Zobellia
galactanivorans) 		4 / 8 ILE A 287
THR A  41
VAL A  40
SER A  55
 None
 1.05A 6fbvC-4citA:
0.0		 6fbvC-4citA:
16.06