SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ciu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 4ciu CHAPERONE PROTEIN
CLPB
(Escherichia
coli) 		5 / 9 LEU A 566
VAL A 580
VAL A 673
ILE A 715
VAL A 713
 None
 1.37A 2l8mA-4ciuA:
undetectable		 2l8mA-4ciuA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 4ciu CHAPERONE PROTEIN
CLPB
(Escherichia
coli) 		3 / 3 GLU A 480
GLN A 488
ARG A 491
 None
 0.91A 2w3bB-4ciuA:
undetectable		 2w3bB-4ciuA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 4ciu CHAPERONE PROTEIN
CLPB
(Escherichia
coli) 		5 / 11 LEU A 219
VAL A 216
ILE A 223
GLU A 217
ALA A 220
 None
 1.10A 2yy8A-4ciuA:
undetectable
2yy8B-4ciuA:
undetectable		 2yy8A-4ciuA:
15.41
2yy8B-4ciuA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 4ciu CHAPERONE PROTEIN
CLPB
(Escherichia
coli) 		4 / 4 VAL A 338
ASP A 278
LEU A 168
ARG A 183
 None
ADP  A 901 ( 4.9A)
None
None
 1.32A 2ziaA-4ciuA:
undetectable		 2ziaA-4ciuA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 4ciu CHAPERONE PROTEIN
CLPB
(Escherichia
coli) 		4 / 5 LEU A 509
GLN A 481
LEU A 479
GLU A 478
 None
 1.13A 3h5gA-4ciuA:
undetectable
3h5gB-4ciuA:
undetectable		 3h5gA-4ciuA:
3.30
3h5gB-4ciuA:
3.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 4ciu CHAPERONE PROTEIN
CLPB
(Escherichia
coli) 		5 / 12 ARG A 351
ILE A 536
ALA A 372
THR A 375
VAL A 343
 None
 1.20A 3s79A-4ciuA:
undetectable		 3s79A-4ciuA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 4ciu CHAPERONE PROTEIN
CLPB
(Escherichia
coli) 		3 / 3 ARG A 491
ARG A 490
ILE A 224
 None
 0.86A 4b7qA-4ciuA:
undetectable		 4b7qA-4ciuA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 4ciu CHAPERONE PROTEIN
CLPB
(Escherichia
coli) 		4 / 5 LEU A 766
GLY A 767
ILE A 571
GLN A 573
 None
None
ADP  A 902 (-4.5A)
None
 1.20A 4ma8C-4ciuA:
2.7		 4ma8C-4ciuA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 4ciu CHAPERONE PROTEIN
CLPB
(Escherichia
coli) 		3 / 3 THR A 663
ASN A 688
PHE A 687
 None
 0.74A 4pd9A-4ciuA:
undetectable		 4pd9A-4ciuA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4ciu CHAPERONE PROTEIN
CLPB
(Escherichia
coli) 		5 / 9 LEU A 540
LEU A 376
ALA A 397
VAL A 531
ALA A 372
 None
 1.20A 5g44A-4ciuA:
undetectable		 5g44A-4ciuA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 4ciu CHAPERONE PROTEIN
CLPB
(Escherichia
coli) 		5 / 12 ARG A 351
ILE A 536
ALA A 372
THR A 375
VAL A 343
 None
 1.19A 5jkvA-4ciuA:
undetectable		 5jkvA-4ciuA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 4ciu CHAPERONE PROTEIN
CLPB
(Escherichia
coli) 		4 / 8 GLN A 454
GLU A 459
ILE A 419
GLN A 426
 None
 1.06A 5vlmD-4ciuA:
2.3		 5vlmD-4ciuA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4ciu CHAPERONE PROTEIN
CLPB
(Escherichia
coli) 		4 / 7 VAL A 216
VAL A 336
PRO A 202
GLY A 312
 None
 0.88A 5x80C-4ciuA:
2.3
5x80D-4ciuA:
1.5		 5x80C-4ciuA:
14.69
5x80D-4ciuA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4ciu CHAPERONE PROTEIN
CLPB
(Escherichia
coli) 		5 / 12 LEU A 694
PHE A 601
VAL A 714
PRO A 597
GLY A 590
 None
 1.20A 5xiqA-4ciuA:
undetectable		 5xiqA-4ciuA:
22.06