SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cj0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4D_A_TOYA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		5 / 10 ASP A 361
GLU A 395
ALA A 563
THR A 462
ASP A 401
 CA  A1576 (-2.2A)
None
None
None
CA  A1576 ( 4.9A)
 1.50A 1m4dA-4cj0A:
undetectable		 1m4dA-4cj0A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		5 / 12 PHE A 398
LEU A 431
VAL A 472
PHE A 409
ALA A 486
 None
 1.35A 1q23A-4cj0A:
undetectable
1q23B-4cj0A:
undetectable		 1q23A-4cj0A:
15.26
1q23B-4cj0A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		4 / 8 TYR A 499
TRP A 544
THR A 553
CYH A 459
 None
 1.46A 1uw6A-4cj0A:
undetectable
1uw6B-4cj0A:
undetectable		 1uw6A-4cj0A:
17.97
1uw6B-4cj0A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		4 / 8 TYR A 499
TRP A 544
THR A 553
CYH A 459
 None
 1.50A 1uw6D-4cj0A:
undetectable
1uw6E-4cj0A:
undetectable		 1uw6D-4cj0A:
17.97
1uw6E-4cj0A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		4 / 8 TYR A 499
TRP A 544
THR A 553
CYH A 459
 None
 1.47A 1uw6G-4cj0A:
undetectable
1uw6H-4cj0A:
undetectable		 1uw6G-4cj0A:
17.97
1uw6H-4cj0A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		4 / 8 TYR A 499
TRP A 544
THR A 553
CYH A 459
 None
 1.45A 1uw6P-4cj0A:
undetectable
1uw6Q-4cj0A:
undetectable		 1uw6P-4cj0A:
17.97
1uw6Q-4cj0A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		4 / 7 ASN A 561
GLY A 149
THR A 145
MET A 150
 None
 1.18A 2o5yH-4cj0A:
6.0
2o5yL-4cj0A:
6.7		 2o5yH-4cj0A:
16.64
2o5yL-4cj0A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		3 / 3 SER A 331
HIS A 269
ASP A 198
 None
 0.77A 2oxtA-4cj0A:
undetectable		 2oxtA-4cj0A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ARG A 519
SER A 520
TYR A 202
 None
 0.83A 2q2hA-4cj0A:
undetectable
2q2hB-4cj0A:
undetectable		 2q2hA-4cj0A:
12.56
2q2hB-4cj0A:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		4 / 4 ALA A 368
TYR A 379
ALA A 304
TYR A 332
 None
None
None
GOL  A1580 ( 4.7A)
 1.30A 2wlkA-4cj0A:
undetectable
2wlkB-4cj0A:
undetectable		 2wlkA-4cj0A:
18.60
2wlkB-4cj0A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_B_ADNB502_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		4 / 5 ASP A 399
TRP A 560
PHE A 398
VAL A 464
 GOL  A1583 (-3.6A)
None
None
None
 1.47A 2zbuB-4cj0A:
0.0		 2zbuB-4cj0A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LEU A 232
ASN A 573
ILE A 565
THR A 212
LEU A 248
 None
 1.37A 3a51B-4cj0A:
undetectable		 3a51B-4cj0A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		5 / 12 MET A 258
VAL A 207
ALA A 209
VAL A 292
VAL A 403
 None
 1.25A 3dl9A-4cj0A:
undetectable		 3dl9A-4cj0A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGG_A_CHDA211_0
(CMER)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		4 / 7 PHE A 132
PHE A 110
SER A 129
TYR A 120
 None
 1.36A 3hggA-4cj0A:
undetectable		 3hggA-4cj0A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		4 / 8 THR A 454
LEU A 451
GLN A 466
ALA A 396
 None
 1.03A 3kp6A-4cj0A:
undetectable		 3kp6A-4cj0A:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		4 / 7 LEU A 245
ASP A 246
LYS A 249
SER A 240
 None
CA  A1577 (-3.0A)
None
None
 0.80A 3lslA-4cj0A:
undetectable
3lslD-4cj0A:
undetectable		 3lslA-4cj0A:
18.02
3lslD-4cj0A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		4 / 7 TYR A 139
ASN A 484
LEU A 487
ASP A 488
 None
 1.33A 3lslA-4cj0A:
undetectable
3lslD-4cj0A:
undetectable		 3lslA-4cj0A:
18.02
3lslD-4cj0A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		4 / 7 SER A 240
LEU A 245
ASP A 246
LYS A 249
 None
None
CA  A1577 (-3.0A)
None
 0.85A 3lslA-4cj0A:
undetectable
3lslD-4cj0A:
undetectable		 3lslA-4cj0A:
18.02
3lslD-4cj0A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		4 / 7 TYR A 139
ASN A 484
LEU A 487
ASP A 488
 None
 1.31A 3lslA-4cj0A:
undetectable
3lslD-4cj0A:
undetectable		 3lslA-4cj0A:
18.02
3lslD-4cj0A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		4 / 6 TYR A 139
ASN A 484
LEU A 487
ASP A 488
 None
 1.32A 3lslG-4cj0A:
undetectable		 3lslG-4cj0A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		4 / 8 TYR A 499
HIS A 492
TRP A 544
LEU A 533
 None
 1.11A 3uzzB-4cj0A:
undetectable		 3uzzB-4cj0A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		3 / 3 TRP A 538
VAL A 534
TRP A 457
 None
 1.14A 3zq8A-4cj0A:
undetectable
3zq8B-4cj0A:
undetectable		 3zq8A-4cj0A:
2.13
3zq8B-4cj0A:
2.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ARG A 501
ASN A 510
ILE A 509
ASN A 497
 None
 1.07A 4d33A-4cj0A:
undetectable		 4d33A-4cj0A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		4 / 7 ARG A 501
ASN A 510
ILE A 509
ASN A 497
 None
 1.10A 4d33B-4cj0A:
undetectable		 4d33B-4cj0A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		4 / 6 THR A 454
HIS A 445
HIS A 492
TYR A 456
 None
None
None
GOL  B1067 ( 3.5A)
 1.48A 4df2A-4cj0A:
undetectable		 4df2A-4cj0A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ILE A 241
ASP A 246
ASP A 243
ILE A 234
GLU A 233
 None
CA  A1577 (-3.0A)
CA  A1577 (-3.3A)
None
None
 1.19A 4i41A-4cj0A:
undetectable		 4i41A-4cj0A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJQ_A_27RA401_1
(DNA POLYMERASE III
SUBUNIT BETA)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		4 / 5 TYR A 168
THR A 145
PRO A 530
VAL A 504
 None
 1.41A 4mjqA-4cj0A:
undetectable		 4mjqA-4cj0A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ASN A 114
VAL A 113
GLY A  60
ILE A  59
ILE A 490
 None
 1.32A 4xucA-4cj0A:
undetectable		 4xucA-4cj0A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		4 / 8 LEU A 256
ASN A 326
ALA A 327
VAL A 330
 None
 0.77A 4zbqA-4cj0A:
undetectable		 4zbqA-4cj0A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DGR_A_GCSA602_1
(PUTATIVE
ENDOGLUCANASE-RELATE
D PROTEIN)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ASP A 198
ALA A 199
ASP A 201
TYR A 205
GLU A 555
 None
None
GOL  A1582 (-4.4A)
None
GOL  A1582 (-3.0A)
 0.70A 5dgrA-4cj0A:
29.5		 5dgrA-4cj0A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LEU A 245
PHE A 244
LEU A 248
ILE A 211
LEU A 406
 None
 1.11A 5ienB-4cj0A:
undetectable		 5ienB-4cj0A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_B_ACTB401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		4 / 5 ARG A 449
LEU A 451
ASN A 460
VAL A 463
 None
 1.46A 5os7B-4cj0A:
undetectable		 5os7B-4cj0A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_0
(REGULATORY PROTEIN
TETR)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		5 / 12 MET A 216
ALA A 209
LEU A 248
ARG A 154
TYR A 532
 None
 1.37A 5vlmH-4cj0A:
1.2		 5vlmH-4cj0A:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		5 / 9 ASP A 488
ASN A 484
SER A  66
SER A 491
GLY A 495
 None
 1.37A 6awpA-4cj0A:
undetectable		 6awpA-4cj0A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4cj0 ENDOGLUCANASE D
E12 AFFITIN
(Ruminiclostridiu
m
thermocellum;
synthetic
construct) 		4 / 7 ALA B  54
GLN B  35
VAL B  34
PRO A 539
 None
 0.84A 6cduA-4cj0B:
undetectable
6cduE-4cj0B:
undetectable		 6cduA-4cj0B:
13.27
6cduE-4cj0B:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4cj0 ENDOGLUCANASE D
E12 AFFITIN
(Ruminiclostridiu
m
thermocellum;
synthetic
construct) 		4 / 6 GLN B  35
VAL B  34
PRO A 539
ALA B  54
 None
 1.04A 6cduB-4cj0B:
undetectable
6cduC-4cj0B:
undetectable		 6cduB-4cj0B:
13.27
6cduC-4cj0B:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4cj0 ENDOGLUCANASE D
E12 AFFITIN
(Ruminiclostridiu
m
thermocellum;
synthetic
construct) 		4 / 7 GLN B  35
VAL B  34
PRO A 539
ALA B  54
 None
 0.94A 6cduC-4cj0B:
undetectable
6cduD-4cj0B:
undetectable		 6cduC-4cj0B:
13.27
6cduD-4cj0B:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4cj0 ENDOGLUCANASE D
E12 AFFITIN
(Ruminiclostridiu
m
thermocellum;
synthetic
construct) 		4 / 7 ALA B  54
GLN B  35
VAL B  34
PRO A 539
 None
 0.88A 6cduF-4cj0B:
undetectable
6cduJ-4cj0B:
undetectable		 6cduF-4cj0B:
13.27
6cduJ-4cj0B:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4cj0 ENDOGLUCANASE D
E12 AFFITIN
(Ruminiclostridiu
m
thermocellum;
synthetic
construct) 		4 / 7 GLN B  35
VAL B  34
PRO A 539
ALA B  54
 None
 0.83A 6cduH-4cj0B:
undetectable
6cduI-4cj0B:
undetectable		 6cduH-4cj0B:
13.27
6cduI-4cj0B:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNK_A_NCTA405_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		4 / 6 TYR A 499
TRP A 544
THR A 553
CYH A 459
 None
 1.39A 6cnkA-4cj0A:
4.3
6cnkB-4cj0A:
4.4		 6cnkA-4cj0A:
8.00
6cnkB-4cj0A:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		4 / 7 ASP A 262
PHE A 334
SER A 264
GLY A 265
 None
 0.96A 6ekzA-4cj0A:
undetectable		 6ekzA-4cj0A:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_A_ACTA401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		4 / 5 ARG A 449
LEU A 451
ASN A 460
VAL A 463
 None
 1.46A 6gmdA-4cj0A:
undetectable		 6gmdA-4cj0A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		4 / 4 LYS A 475
LEU A 413
ALA A 473
LEU A 412
 None
 1.48A 6gnrA-4cj0A:
3.8		 6gnrA-4cj0A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		4 / 4 LYS A 475
LEU A 413
ALA A 473
LEU A 412
 None
 1.48A 6gnrB-4cj0A:
3.7		 6gnrB-4cj0A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ASP A 517
ARG A 519
ASN A 559
TYR A 205
 None
 0.99A 6hisA-4cj0A:
2.4
6hisB-4cj0A:
2.5		 6hisA-4cj0A:
8.80
6hisB-4cj0A:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ASP A 517
ARG A 519
ASN A 559
TYR A 205
 None
 0.98A 6hisB-4cj0A:
2.5
6hisC-4cj0A:
2.4		 6hisB-4cj0A:
8.80
6hisC-4cj0A:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ASP A 517
ARG A 519
ASN A 559
TYR A 205
 None
 0.98A 6hisC-4cj0A:
2.4
6hisD-4cj0A:
undetectable		 6hisC-4cj0A:
8.80
6hisD-4cj0A:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ASP A 517
ARG A 519
ASN A 559
TYR A 205
 None
 1.00A 6hisD-4cj0A:
undetectable
6hisE-4cj0A:
2.4		 6hisD-4cj0A:
8.80
6hisE-4cj0A:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ASN A 559
TYR A 205
ASP A 517
ARG A 519
 None
 0.98A 6hisA-4cj0A:
2.4
6hisE-4cj0A:
2.4		 6hisA-4cj0A:
8.80
6hisE-4cj0A:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 4cj0 ENDOGLUCANASE D
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ILE A 312
LEU A 248
ARG A 154
ASP A 253
LEU A 256
 None
 1.24A 6ie8A-4cj0A:
0.5		 6ie8A-4cj0A:
15.11