SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cjm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 4cjm FIBROBLAST GROWTH
FACTOR 18
(Homo
sapiens) 		4 / 5 SER A 124
LEU A 116
GLY A 118
GLU A 126
 SO4  A1181 (-2.8A)
None
None
None
 0.98A 3aiaA-4cjmA:
undetectable
3aiaB-4cjmA:
undetectable		 3aiaA-4cjmA:
22.40
3aiaB-4cjmA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4cjm FIBROBLAST GROWTH
FACTOR 18
(Homo
sapiens) 		5 / 12 GLU A 131
LEU A 141
VAL A  97
ILE A  66
LEU A 108
 None
 1.15A 3datA-4cjmA:
undetectable		 3datA-4cjmA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 4cjm FIBROBLAST GROWTH
FACTOR 18
(Homo
sapiens) 		3 / 3 ARG A 160
LYS A 161
LYS A 164
 SO4  A1182 (-4.1A)
SO4  A1182 (-4.3A)
SO4  A1182 (-3.4A)
 0.92A 4k50A-4cjmA:
undetectable		 4k50A-4cjmA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 4cjm FIBROBLAST GROWTH
FACTOR 18
(Homo
sapiens) 		3 / 3 ARG A 160
LYS A 161
LYS A 164
 SO4  A1182 (-4.1A)
SO4  A1182 (-4.3A)
SO4  A1182 (-3.4A)
 1.03A 4k50E-4cjmA:
undetectable		 4k50E-4cjmA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 4cjm FIBROBLAST GROWTH
FACTOR 18
(Homo
sapiens) 		3 / 3 ARG A 160
LYS A 161
LYS A 164
 SO4  A1182 (-4.1A)
SO4  A1182 (-4.3A)
SO4  A1182 (-3.4A)
 1.01A 4k50I-4cjmA:
undetectable		 4k50I-4cjmA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		 4cjm FIBROBLAST GROWTH
FACTOR 18
(Homo
sapiens) 		4 / 4 ALA A 140
VAL A 151
GLY A 162
THR A 165
 None
 0.98A 4ubeA-4cjmA:
undetectable		 4ubeA-4cjmA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 4cjm FIBROBLAST GROWTH
FACTOR 18
(Homo
sapiens) 		4 / 6 GLU A  78
HIS A  65
ALA A  84
GLN A  85
 None
 1.47A 6f6jC-4cjmA:
undetectable
6f6jD-4cjmA:
undetectable		 6f6jC-4cjmA:
15.13
6f6jD-4cjmA:
15.13