SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4cke'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 4cke MRNA-CAPPING ENZYME
REGULATORY SUBUNIT
(Vaccinia
virus) 		5 / 11 CYH B 153
LEU B 157
LEU B 233
VAL B 140
ILE B 171
 None
 1.34A 1ee2A-4ckeB:
undetectable		 1ee2A-4ckeB:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4cke MRNA-CAPPING ENZYME
REGULATORY SUBUNIT
(Vaccinia
virus) 		5 / 12 VAL B 237
LEU B 157
LEU B 136
THR B 159
GLY B  40
 None
 1.08A 1jffB-4ckeB:
undetectable		 1jffB-4ckeB:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4cke MRNA-CAPPING ENZYME
REGULATORY SUBUNIT
(Vaccinia
virus) 		5 / 12 VAL B 237
LEU B 157
LEU B 136
THR B 159
GLY B  40
 None
 1.08A 2hxfB-4ckeB:
undetectable		 2hxfB-4ckeB:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4cke MRNA-CAPPING ENZYME
REGULATORY SUBUNIT
(Vaccinia
virus) 		5 / 12 VAL B 237
LEU B 157
LEU B 136
THR B 159
GLY B  40
 None
 1.08A 2hxhB-4ckeB:
undetectable		 2hxhB-4ckeB:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4cke MRNA-CAPPING ENZYME
REGULATORY SUBUNIT
(Vaccinia
virus) 		5 / 12 VAL B 237
LEU B 157
LEU B 136
THR B 159
GLY B  40
 None
 1.08A 2p4nB-4ckeB:
undetectable		 2p4nB-4ckeB:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 4cke MRNA-CAPPING ENZYME
REGULATORY SUBUNIT
(Vaccinia
virus) 		4 / 8 SER B  32
TYR B 133
LEU B 128
THR B 168
 None
 1.11A 2v0zO-4ckeB:
undetectable		 2v0zO-4ckeB:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)		 4cke MRNA-CAPPING ENZYME
REGULATORY SUBUNIT
(Vaccinia
virus) 		5 / 12 VAL B 237
LEU B 157
LEU B 136
THR B 159
GLY B  40
 None
 1.08A 2wbeB-4ckeB:
undetectable		 2wbeB-4ckeB:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)		 4cke MRNA-CAPPING ENZYME
REGULATORY SUBUNIT
(Vaccinia
virus) 		5 / 12 VAL B 237
LEU B 157
LEU B 136
THR B 159
GLY B  40
 None
 1.08A 3dcoB-4ckeB:
undetectable		 3dcoB-4ckeB:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)		 4cke MRNA-CAPPING ENZYME
REGULATORY SUBUNIT
(Vaccinia
virus) 		5 / 12 VAL B 237
LEU B 157
LEU B 136
THR B 159
GLY B  40
 None
 1.06A 3edlB-4ckeB:
undetectable		 3edlB-4ckeB:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)		 4cke MRNA-CAPPING ENZYME
REGULATORY SUBUNIT
(Vaccinia
virus) 		5 / 12 VAL B 237
LEU B 157
LEU B 136
THR B 159
GLY B  40
 None
 1.05A 3iz0B-4ckeB:
undetectable		 3iz0B-4ckeB:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)		 4cke MRNA-CAPPING ENZYME
REGULATORY SUBUNIT
(Vaccinia
virus) 		3 / 3 ASN B 107
GLU B  72
ARG B 106
 None
 1.08A 3wxoA-4ckeB:
undetectable		 3wxoA-4ckeB:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_1
(ANDROGEN RECEPTOR)		 4cke MRNA-CAPPING ENZYME
REGULATORY SUBUNIT
(Vaccinia
virus) 		5 / 12 LEU B 157
LEU B  16
VAL B 197
HIS B  13
THR B  12
 None
 1.23A 4ojbA-4ckeB:
undetectable		 4ojbA-4ckeB:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 4cke MRNA-CAPPING ENZYME
REGULATORY SUBUNIT
(Vaccinia
virus) 		3 / 3 LEU B 160
MET B 135
TYR B  39
 None
 0.91A 4p6xG-4ckeB:
undetectable		 4p6xG-4ckeB:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_C_SAMC401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4cke MRNA-CAPPING ENZYME
REGULATORY SUBUNIT
(Vaccinia
virus) 		5 / 11 SER B 249
GLY B 164
ASP B 167
LEU B 233
VAL B 237
 None
 1.47A 4pghC-4ckeB:
2.9		 4pghC-4ckeB:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 4cke MRNA-CAPPING ENZYME
REGULATORY SUBUNIT
(Vaccinia
virus) 		6 / 12 ASP B 192
HIS B 260
LEU B 263
SER B 188
LEU B  61
THR B  58
 None
 1.45A 5hnwB-4ckeB:
undetectable		 5hnwB-4ckeB:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 4cke MRNA-CAPPING ENZYME
REGULATORY SUBUNIT
(Vaccinia
virus) 		6 / 12 ASP B 192
HIS B 260
LEU B 263
SER B 188
LEU B  61
THR B  58
 None
 1.47A 5hnxB-4ckeB:
undetectable		 5hnxB-4ckeB:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4cke MRNA-CAPPING ENZYME
REGULATORY SUBUNIT
(Vaccinia
virus) 		6 / 12 ASP B 192
HIS B 260
LEU B 263
SER B 188
LEU B  61
THR B  58
 None
 1.46A 5hnyB-4ckeB:
undetectable		 5hnyB-4ckeB:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4cke MRNA-CAPPING ENZYME
REGULATORY SUBUNIT
(Vaccinia
virus) 		5 / 12 ASP B 192
HIS B 260
LEU B 263
SER B 188
THR B  58
 None
 1.09A 5nd3B-4ckeB:
undetectable		 5nd3B-4ckeB:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 4cke MRNA-CAPPING ENZYME
REGULATORY SUBUNIT
(Vaccinia
virus) 		4 / 7 ARG B 142
LEU B  29
PHE B 230
THR B 168
 None
 0.81A 5vc0A-4ckeB:
undetectable		 5vc0A-4ckeB:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 4cke MRNA-CAPPING ENZYME
REGULATORY SUBUNIT
(Vaccinia
virus) 		4 / 6 ARG B 142
PHE B 230
ILE B 171
THR B 168
 None
 0.98A 5vceA-4ckeB:
undetectable		 5vceA-4ckeB:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4cke MRNA-CAPPING ENZYME
REGULATORY SUBUNIT
(Vaccinia
virus) 		5 / 9 LEU B 160
THR B 159
GLY B 164
ILE B 166
PHE B 248
 None
 1.19A 6ebpA-4ckeB:
undetectable		 6ebpA-4ckeB:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4cke MRNA-CAPPING ENZYME
REGULATORY SUBUNIT
(Vaccinia
virus) 		5 / 10 LEU B 160
THR B 159
GLY B 164
ILE B 166
PHE B 248
 None
 1.19A 6ebpB-4ckeB:
undetectable		 6ebpB-4ckeB:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4cke MRNA-CAPPING ENZYME
REGULATORY SUBUNIT
(Vaccinia
virus) 		5 / 10 LEU B 160
THR B 159
GLY B 164
ILE B 166
PHE B 248
 None
 1.13A 6ebpC-4ckeB:
undetectable		 6ebpC-4ckeB:
13.24