SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ckg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 4ckg ARF-GAP WITH
COILED-COIL, ANK
REPEAT AND PH
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 7 PHE A  83
GLU A 209
LEU A 213
THR A  84
 None
 1.16A 1rmtB-4ckgA:
undetectable		 1rmtB-4ckgA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 4ckg ARF-GAP WITH
COILED-COIL, ANK
REPEAT AND PH
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 7 GLU A  27
GLY A  -1
PHE A   7
ILE A 177
 None
 1.03A 2qmzA-4ckgA:
undetectable
2qmzB-4ckgA:
undetectable		 2qmzA-4ckgA:
21.28
2qmzB-4ckgA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4ckg ARF-GAP WITH
COILED-COIL, ANK
REPEAT AND PH
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 6 PHE A 329
PRO A 257
LEU A 347
ALA A 342
 None
 0.89A 2vcvB-4ckgA:
1.9		 2vcvB-4ckgA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4ckg ARF-GAP WITH
COILED-COIL, ANK
REPEAT AND PH
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 6 PHE A 329
PRO A 257
LEU A 347
ALA A 342
 None
 0.98A 2vcvK-4ckgA:
undetectable		 2vcvK-4ckgA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 4ckg ARF-GAP WITH
COILED-COIL, ANK
REPEAT AND PH
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 8 GLN A 102
LEU A  39
LYS A  40
LEU A  46
 None
 0.72A 2xn3A-4ckgA:
undetectable
2xn3B-4ckgA:
undetectable		 2xn3A-4ckgA:
20.60
2xn3B-4ckgA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4ckg ARF-GAP WITH
COILED-COIL, ANK
REPEAT AND PH
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 5 LEU A  98
LEU A  45
GLY A  44
GLY A  42
 None
 0.74A 3si7C-4ckgA:
undetectable
3si7D-4ckgA:
undetectable		 3si7C-4ckgA:
21.56
3si7D-4ckgA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		 4ckg ARF-GAP WITH
COILED-COIL, ANK
REPEAT AND PH
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 10 LEU A 159
ALA A 155
SER A 133
LEU A 134
ALA A 162
 None
 0.90A 4zbrA-4ckgA:
2.0		 4zbrA-4ckgA:
21.27