SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ckk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_B_ACAB90_1
(PLASMINOGEN)		 4ckk DNA GYRASE SUBUNIT A
(Escherichia
coli) 		4 / 7 ARG A 433
ASP A 445
TYR A 448
TYR A 449
 None
 1.48A 1ceaB-4ckkA:
undetectable		 1ceaB-4ckkA:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 4ckk DNA GYRASE SUBUNIT A
(Escherichia
coli) 		4 / 6 GLY A 418
TYR A 448
ALA A 384
GLU A 381
 None
 0.97A 1dmaB-4ckkA:
undetectable		 1dmaB-4ckkA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 4ckk DNA GYRASE SUBUNIT A
(Escherichia
coli) 		5 / 10 LEU A 450
ALA A 386
LEU A 410
LEU A 461
ALA A 457
 None
 1.31A 1ie4A-4ckkA:
undetectable
1ie4C-4ckkA:
undetectable		 1ie4A-4ckkA:
17.69
1ie4C-4ckkA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 4ckk DNA GYRASE SUBUNIT A
(Escherichia
coli) 		5 / 10 LEU A 461
ALA A 457
LEU A 450
ALA A 386
LEU A 410
 None
 1.34A 1ie4A-4ckkA:
undetectable
1ie4C-4ckkA:
undetectable		 1ie4A-4ckkA:
17.69
1ie4C-4ckkA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4ckk DNA GYRASE SUBUNIT A
(Escherichia
coli) 		3 / 3 ILE A 229
ASP A 216
PHE A 217
 None
 0.58A 1uwjB-4ckkA:
0.2		 1uwjB-4ckkA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4ckk DNA GYRASE SUBUNIT A
(Escherichia
coli) 		5 / 9 VAL A 268
LEU A 273
MET A 301
SER A 296
LEU A 326
 None
 1.32A 1wrkA-4ckkA:
0.0
1wrkB-4ckkA:
undetectable		 1wrkA-4ckkA:
10.29
1wrkB-4ckkA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4ckk DNA GYRASE SUBUNIT A
(Escherichia
coli) 		5 / 12 CYH A 194
HIS A 185
LEU A 187
VAL A 509
LEU A 347
 None
 1.29A 3g9eA-4ckkA:
undetectable		 3g9eA-4ckkA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 4ckk DNA GYRASE SUBUNIT A
(Escherichia
coli) 		4 / 6 ARG A 517
PHE A 217
TYR A 266
PRO A 215
 None
 1.37A 3jqaA-4ckkA:
undetectable		 3jqaA-4ckkA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 4ckk DNA GYRASE SUBUNIT A
(Escherichia
coli) 		4 / 6 ARG A 517
PHE A 217
TYR A 266
PRO A 215
 None
 1.30A 3jqaC-4ckkA:
undetectable		 3jqaC-4ckkA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 4ckk DNA GYRASE SUBUNIT A
(Escherichia
coli) 		4 / 6 ARG A 517
PHE A 217
TYR A 266
PRO A 215
 None
 1.33A 3jqaD-4ckkA:
undetectable		 3jqaD-4ckkA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4ckk DNA GYRASE SUBUNIT A
(Escherichia
coli) 		3 / 3 ARG A 358
GLU A 360
THR A 142
 None
 0.86A 3v4tA-4ckkA:
undetectable		 3v4tA-4ckkA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4ckk DNA GYRASE SUBUNIT A
(Escherichia
coli) 		5 / 9 ASP A 104
ILE A 125
GLY A 105
PHE A 109
THR A 123
 None
 1.41A 4acaB-4ckkA:
undetectable
4acaC-4ckkA:
undetectable		 4acaB-4ckkA:
24.28
4acaC-4ckkA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 4ckk DNA GYRASE SUBUNIT A
(Escherichia
coli) 		3 / 3 GLY A 105
GLU A 124
THR A 123
 None
 0.57A 4kouA-4ckkA:
undetectable		 4kouA-4ckkA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4ckk DNA GYRASE SUBUNIT A
(Escherichia
coli) 		5 / 12 HIS A 185
LEU A 187
VAL A 509
LEU A 347
TYR A 233
 None
 1.50A 4o8fB-4ckkA:
1.3		 4o8fB-4ckkA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 4ckk DNA GYRASE SUBUNIT A
(Escherichia
coli) 		4 / 7 VAL A 268
GLN A 325
LEU A 273
GLU A 275
 None
 0.81A 4zphA-4ckkA:
undetectable
4zphB-4ckkA:
undetectable		 4zphA-4ckkA:
23.33
4zphB-4ckkA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4ckk DNA GYRASE SUBUNIT A
(Escherichia
coli) 		4 / 5 LEU A 380
ALA A 384
LEU A 387
LEU A 424
 None
 0.85A 5vkqA-4ckkA:
2.6
5vkqD-4ckkA:
2.6		 5vkqA-4ckkA:
15.08
5vkqD-4ckkA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4ckk DNA GYRASE SUBUNIT A
(Escherichia
coli) 		4 / 7 THR A 519
PHE A 217
HIS A 185
ILE A 212
 None
 1.15A 5vkqA-4ckkA:
2.6
5vkqB-4ckkA:
2.6		 5vkqA-4ckkA:
15.08
5vkqB-4ckkA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4ckk DNA GYRASE SUBUNIT A
(Escherichia
coli) 		4 / 5 LEU A 424
LEU A 380
ALA A 384
LEU A 387
 None
 0.85A 5vkqA-4ckkA:
2.6
5vkqB-4ckkA:
2.6		 5vkqA-4ckkA:
15.08
5vkqB-4ckkA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4ckk DNA GYRASE SUBUNIT A
(Escherichia
coli) 		4 / 8 THR A 519
PHE A 217
HIS A 185
ILE A 212
 None
 1.14A 5vkqB-4ckkA:
2.6
5vkqC-4ckkA:
2.6		 5vkqB-4ckkA:
15.08
5vkqC-4ckkA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4ckk DNA GYRASE SUBUNIT A
(Escherichia
coli) 		4 / 5 LEU A 424
LEU A 380
ALA A 384
LEU A 387
 None
 0.84A 5vkqB-4ckkA:
2.6
5vkqC-4ckkA:
2.6		 5vkqB-4ckkA:
15.08
5vkqC-4ckkA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4ckk DNA GYRASE SUBUNIT A
(Escherichia
coli) 		4 / 7 THR A 519
PHE A 217
HIS A 185
ILE A 212
 None
 1.12A 5vkqC-4ckkA:
2.6
5vkqD-4ckkA:
2.6		 5vkqC-4ckkA:
15.08
5vkqD-4ckkA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4ckk DNA GYRASE SUBUNIT A
(Escherichia
coli) 		4 / 5 LEU A 424
LEU A 380
ALA A 384
LEU A 387
 None
 0.86A 5vkqC-4ckkA:
2.6
5vkqD-4ckkA:
2.6		 5vkqC-4ckkA:
15.08
5vkqD-4ckkA:
15.08