SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ckm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 4ckm SAS-6
(Leishmania
major) 		5 / 11 LEU A 177
VAL A 157
GLY A 156
THR A 138
ILE A 223
 None
 0.96A 1phgA-4ckmA:
undetectable		 1phgA-4ckmA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 4ckm SAS-6
(Leishmania
major) 		3 / 3 ASP A 179
LEU A 155
HIS A 148
 None
 0.71A 1qknA-4ckmA:
undetectable		 1qknA-4ckmA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4ckm SAS-6
(Leishmania
major) 		5 / 12 VAL A 173
LEU A 220
PHE A 212
ILE A 263
LEU A 205
 None
 1.15A 2oipA-4ckmA:
undetectable		 2oipA-4ckmA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 4ckm SAS-6
(Leishmania
major) 		5 / 11 TYR A 196
PHE A 209
VAL A 173
ILE A 263
PHE A 199
 None
 1.43A 2vn1A-4ckmA:
undetectable		 2vn1A-4ckmA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4ckm SAS-6
(Leishmania
major) 		3 / 3 LYS A 242
ARG A 153
LEU A 236
 None
 0.79A 3v4tE-4ckmA:
undetectable		 3v4tE-4ckmA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAW_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4ckm SAS-6
(Leishmania
major) 		5 / 11 TYR A 196
PHE A 209
VAL A 173
ILE A 263
PHE A 199
 None
 1.34A 3vawA-4ckmA:
undetectable		 3vawA-4ckmA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ2_A_FK5A200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4ckm SAS-6
(Leishmania
major) 		5 / 11 TYR A 196
PHE A 209
VAL A 173
ILE A 263
PHE A 199
 None
 1.37A 4dz2A-4ckmA:
undetectable
4dz2B-4ckmA:
undetectable		 4dz2A-4ckmA:
20.00
4dz2B-4ckmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ2_B_FK5B200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4ckm SAS-6
(Leishmania
major) 		5 / 11 TYR A 196
PHE A 209
VAL A 173
ILE A 263
PHE A 199
 None
 1.40A 4dz2A-4ckmA:
undetectable
4dz2B-4ckmA:
undetectable		 4dz2A-4ckmA:
20.00
4dz2B-4ckmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ3_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4ckm SAS-6
(Leishmania
major) 		5 / 10 TYR A 196
PHE A 209
VAL A 173
ILE A 263
PHE A 199
 None
 1.37A 4dz3A-4ckmA:
undetectable		 4dz3A-4ckmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ3_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4ckm SAS-6
(Leishmania
major) 		5 / 10 TYR A 196
PHE A 209
VAL A 173
ILE A 263
PHE A 199
 None
 1.37A 4dz3B-4ckmA:
undetectable		 4dz3B-4ckmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 4ckm SAS-6
(Leishmania
major) 		5 / 12 TYR A 196
PHE A 209
VAL A 173
ILE A 263
PHE A 199
 None
 1.37A 4nnrA-4ckmA:
undetectable
4nnrB-4ckmA:
undetectable		 4nnrA-4ckmA:
22.10
4nnrB-4ckmA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 4ckm SAS-6
(Leishmania
major) 		5 / 10 TYR A 196
PHE A 209
VAL A 173
ILE A 263
PHE A 199
 None
 1.39A 4nnrB-4ckmA:
undetectable		 4nnrB-4ckmA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWC_A_FK5A201_1
(FK506-BINDING
PROTEIN 1A)		 4ckm SAS-6
(Leishmania
major) 		5 / 11 TYR A 196
PHE A 209
VAL A 173
ILE A 263
PHE A 199
 None
 1.40A 5hwcA-4ckmA:
undetectable		 5hwcA-4ckmA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 4ckm SAS-6
(Leishmania
major) 		4 / 7 ILE A 263
VAL A 139
LEU A 249
LEU A 135
 None
 0.74A 6g9bA-4ckmA:
undetectable
6g9bB-4ckmA:
undetectable		 6g9bA-4ckmA:
19.88
6g9bB-4ckmA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_1
(PEPTIDYLPROLYL
ISOMERASE)		 4ckm SAS-6
(Leishmania
major) 		5 / 10 TYR A 196
PHE A 209
VAL A 173
ILE A 263
PHE A 199
 None
 1.47A 6mkeC-4ckmA:
undetectable		 6mkeC-4ckmA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_1
(PEPTIDYLPROLYL
ISOMERASE)		 4ckm SAS-6
(Leishmania
major) 		5 / 10 TYR A 196
PHE A 209
VAL A 173
ILE A 263
PHE A 199
 None
 1.42A 6mkeD-4ckmA:
undetectable		 6mkeD-4ckmA:
15.56